(Q45221796)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15647473%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

title

3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors attenuate beta-amyloid-induced microglial inflammatory responses (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15647473%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

0 references

0 references

1 reference

Andrew Cordle

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15647473%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

Gary Landreth

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15647473%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

language of work or name

English

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publication date

1 January 2005

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15647473%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

published in

Journal of Neuroscience

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15647473%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

volume

25

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15647473%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

issue

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15647473%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

page(s)

299-307

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15647473%20AND%20SRC:MED&resulttype=core&format=json

Chemokine and chemokine receptor expression in the central nervous system

7 January 2020

cites work

1 reference

12 December 2020

Atorvastatin reduces NF-kappaB activation and chemokine expression in vascular smooth muscle cells and mononuclear cells

1 reference

12 December 2020

Inflammatory mechanisms in Alzheimer's disease: inhibition of beta-amyloid-stimulated proinflammatory responses and neurotoxicity by PPARgamma agonists.

1 reference

12 December 2020

Amyloid beta and amylin fibrils induce increases in proinflammatory cytokine and chemokine production by THP-1 cells and murine microglia

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12 December 2020

Inflammation and Alzheimer's disease

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12 December 2020

Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease.

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12 December 2020

Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors.

1 reference

12 December 2020

Statins and the risk of dementia

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12 December 2020

Pravastatin down-regulates inflammatory mediators in human monocytes in vitro

1 reference

12 December 2020

beta-Amyloid stimulation of microglia and monocytes results in TNFalpha-dependent expression of inducible nitric oxide synthase and neuronal apoptosis.

1 reference

12 December 2020

Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo

1 reference

12 December 2020

Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha -secretase ADAM 10.

1 reference

12 December 2020

Statins suppress THP-1 cell migration and secretion of matrix metalloproteinase 9 by inhibiting geranylgeranylation.

1 reference

12 December 2020

Neuroinflammation-induced acceleration of amyloid deposition in the APPV717F transgenic mouse

1 reference

12 December 2020

Regulation of beta-amyloid stimulated proinflammatory responses by peroxisome proliferator-activated receptor alpha

1 reference

12 December 2020

A cholesterol-lowering drug reduces beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease

1 reference

12 December 2020

A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

1 reference

12 December 2020

Pleiotropic effects of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors

1 reference

12 December 2020

Ibuprofen decreases cytokine-induced amyloid beta production in neuronal cells.

1 reference

12 December 2020

Use of lipid-lowering agents, indication bias, and the risk of dementia in community-dwelling elderly people.

1 reference

12 December 2020

Modulation of inflammatory mediators and PPARgamma and NFkappaB expression by pravastatin in response to lipoproteins in human monocytes in vitro

1 reference

12 December 2020

Cholesterol-dependent gamma-secretase activity in buoyant cholesterol-rich membrane microdomains

1 reference

12 December 2020

Pharmacological concentrations of the HMG-CoA reductase inhibitor lovastatin decrease the formation of the Alzheimer beta-amyloid peptide in vitro and in patients

1 reference

12 December 2020

Atorvastatin activates PPAR-gamma and attenuates the inflammatory response in human monocytes

1 reference

12 December 2020

Inducible nitric oxide synthase and argininosuccinate synthetase: co-induction in brain tissue of patients with Alzheimer's dementia and following stimulation with beta-amyloid 1-42 in vitro

1 reference

12 December 2020

Cerebrovascular transforming growth factor-beta contributes to inflammation in the Alzheimer's disease brain

1 reference

12 December 2020

Amyloid-beta-induced chemokine production in primary human macrophages and astrocytes

1 reference

12 December 2020

Inflammation-dependent cerebral deposition of serum amyloid a protein in a mouse model of amyloidosis.

1 reference

12 December 2020

Isoprenoids as mediators of the biological effects of statins

1 reference

12 December 2020

Cholesterol and Alzheimer's disease

1 reference

12 December 2020

Treatment with simvastatin in normocholesterolemic patients with Alzheimer's disease: A 26-week randomized, placebo-controlled, double-blind trial

1 reference

12 December 2020

Statin therapy for Alzheimer's disease: will it work?

1 reference

12 December 2020

Statins, 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, are able to reduce superoxide anion production by NADPH oxidase in THP-1-derived monocytes.

1 reference

12 December 2020

The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease

1 reference

12 December 2020

Cholesterol in Alzheimer's disease and tauopathy

1 reference

12 December 2020

Beta-amyloid-induced inflammation and cholinergic hypofunction in the rat brain in vivo: involvement of the p38MAPK pathway.

1 reference

12 December 2020

Alzheimer's disease: the cholesterol connection

1 reference

12 December 2020

A cell surface receptor complex for fibrillar beta-amyloid mediates microglial activation.

1 reference

12 December 2020

Treatment with simvastatin in patients with Alzheimer's disease lowers both alpha- and beta-cleaved amyloid precursor protein

1 reference

12 December 2020

Evidence that nonsteroidal anti-inflammatory drugs decrease amyloid beta 42 production by direct modulation of gamma-secretase activity

1 reference

12 December 2020

Lovastatin and beyond: the history of the HMG-CoA reductase inhibitors

1 reference

12 December 2020

Effect of non-steroidal anti-inflammatory drugs on risk of Alzheimer's disease: systematic review and meta-analysis of observational studies

1 reference

12 December 2020

Inflammatory processes in Alzheimer's disease

1 reference

12 December 2020

Anti-inflammatory drug therapy alters beta-amyloid processing and deposition in an animal model of Alzheimer's disease.

1 reference

12 December 2020

Lipopolysaccharide-induced-neuroinflammation increases intracellular accumulation of amyloid precursor protein and amyloid beta peptide in APPswe transgenic mice.

1 reference

12 December 2020

Exclusively targeting beta-secretase to lipid rafts by GPI-anchor addition up-regulates beta-site processing of the amyloid precursor protein

1 reference

12 December 2020

Nonsteroidal anti-inflammatory drugs and peroxisome proliferator-activated receptor-gamma agonists modulate immunostimulated processing of amyloid precursor protein through regulation of beta-secretase.

1 reference

12 December 2020

Nonsteroidal Anti-Inflammatory Drugs Can Lower Amyloidogenic Aß 42 by Inhibiting Rho

1 reference

12 December 2020

The discovery and development of HMG-CoA reductase inhibitors

1 reference

12 December 2020

3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors protect cortical neurons from excitotoxicity.

1 reference

12 December 2020

Potential targets of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor for multiple sclerosis therapy

1 reference

12 December 2020

Do statins slow down Alzheimer's disease? A review

1 reference

12 December 2020

Atorvastatin-induced activation of Alzheimer's alpha secretase is resistant to standard inhibitors of protein phosphorylation-regulated ectodomain shedding

1 reference

12 December 2020

Immunoreactivity of CD45, a protein phosphotyrosine phosphatase, in Alzheimer's disease

1 reference

12 December 2020

Brain microglia constitutively express beta-2 integrins.

1 reference

12 December 2020

Expression of immune system-associated antigens by cells of the human central nervous system: relationship to the pathology of Alzheimer's disease

1 reference

12 December 2020

Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids

1 reference

12 December 2020

Identification of Fc gamma RI, II and III on normal human brain ramified microglia and on microglia in senile plaques in Alzheimer's disease

1 reference

12 December 2020

Cholesterol modulates alpha-secretase cleavage of amyloid precursor protein

1 reference

12 December 2020

Protein prenylation: molecular mechanisms and functional consequences

1 reference

12 December 2020

Amyloid fibrils activate tyrosine kinase-dependent signaling and superoxide production in microglia.

1 reference

12 December 2020

Lovastatin and phenylacetate inhibit the induction of nitric oxide synthase and cytokines in rat primary astrocytes, microglia, and macrophages

1 reference

12 December 2020

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1 reference

12 December 2020

Fibrillar beta-amyloid induces microglial phagocytosis, expression of inducible nitric oxide synthase, and loss of a select population of neurons in the rat CNS in vivo.

1 reference

12 December 2020

Nonsteroidal anti-inflammatory drug use and Alzheimer-type pathology in aging.

1 reference

12 December 2020

Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons

1 reference

12 December 2020

Immunohistochemical study of the beta-chemokine receptors CCR3 and CCR5 and their ligands in normal and Alzheimer's disease brains

1 reference

12 December 2020

HMG-CoA reductase inhibitors reduce MMP-9 secretion by macrophages

1 reference

12 December 2020

Identification of microglial signal transduction pathways mediating a neurotoxic response to amyloidogenic fragments of beta-amyloid and prion proteins

1 reference

12 December 2020

10.1523/JNEUROSCI.2544-04.2005

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15647473%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15647473%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

1 reference