(Q34405882)

2 August 2017

title

Granzyme B-induced neurotoxicity is mediated via activation of PAR-1 receptor and Kv1.3 channel (English)

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2 August 2017

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7

Peter A Calabresi

1 reference

2 August 2017

Tongguang Wang

1

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2 August 2017

Myoung-Hwa Lee

2

1 reference

2 August 2017

Elliot Choi

3

1 reference

2 August 2017

Carlos A Pardo-Villamizar

4

1 reference

2 August 2017

Sung Bin Lee

5

1 reference

2 August 2017

In Hong Yang

6

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2 August 2017

Avindra Nath

8

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2 August 2017

language of work or name

English

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publication date

29 August 2012

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2 August 2017

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2 August 2017

volume

7

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2 August 2017

issue

8

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2 August 2017

page(s)

e43950

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Creative Commons CC0 License

2 August 2017

copyright license

start time

29 August 2012

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted, dedicated to the public domain by copyright holder

0 references

describes a project that uses

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3430617/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Activated T-cells inhibit neurogenesis by releasing granzyme B: rescue by Kv1.3 blockers

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6 July 2018

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Kv1.3 potassium channels as a therapeutic target in multiple sclerosis

6 July 2018

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Awake intranasal insulin delivery modifies protein complexes and alters memory, anxiety, and olfactory behaviors

6 July 2018

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Cytolytic molecules in rejection

6 July 2018

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CD8+ T-cell clones dominate brain infiltrates in Rasmussen encephalitis and persist in the periphery

6 July 2018

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Brain-derived neurotrophic factor modulation of Kv1.3 channel is disregulated by adaptor proteins Grb10 and nShc

6 July 2018

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Clofazimine inhibits human Kv1.3 potassium channel by perturbing calcium oscillation in T lymphocytes

6 July 2018

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Granzyme B delivery via perforin is restricted by size, but not by heparan sulfate-dependent endocytosis

6 July 2018

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A gamma-secretase inhibitor and quinacrine reduce prions and prevent dendritic degeneration in murine brains

6 July 2018

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Kv1.3 channels in postganglionic sympathetic neurons: expression, function, and modulation

6 July 2018

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Deletion of voltage-gated channel affects glomerular refinement and odorant receptor expression in the mouse olfactory system

6 July 2018

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Inhibition of notch signaling induces neural differentiation in Ewing sarcoma

6 July 2018

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TCR activation eliminates glutamate receptor GluR3 from the cell surface of normal human T cells, via an autocrine/paracrine granzyme B-mediated proteolytic cleavage.

6 July 2018

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Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases

6 July 2018

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Brain CD8+ and cytotoxic T lymphocytes are associated with, and may be specific for, human immunodeficiency virus type 1 encephalitis in patients with acquired immunodeficiency syndrome

6 July 2018

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Granzyme B proteolyzes receptors important to proliferation and survival, tipping the balance toward apoptosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430617

Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia

6 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430617

Doublecortin expression levels in adult brain reflect neurogenesis

6 July 2018

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Notch-1 activation and dendritic atrophy in prion disease

6 July 2018

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A novel potassium channel in lymphocyte mitochondria

6 July 2018

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Membrane receptors are not required to deliver granzyme B during killer cell attack

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430617

Comparison of modulation of Kv1.3 channel by two receptor tyrosine kinases in olfactory bulb neurons of rodents

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430617

The contribution of protease-activated receptor 1 to neuronal damage caused by transient focal cerebral ischemia

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430617

Granzyme B: pro-apoptotic, antiviral and antitumor functions

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430617

Protease-activated receptors: new concepts in regulation of G protein-coupled receptor signaling and trafficking

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430617

Thrombin signaling in the brain: the role of protease-activated receptors

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430617

Actinomycin D-induced apoptosis involves the potassium channel Kv1.3.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430617

Selective blocking of voltage-gated K+ channels improves experimental autoimmune encephalomyelitis and inhibits T cell activation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430617

Calcium-stimulated adenylyl cyclase activity is critical for hippocampus-dependent long-term memory and late phase LTP

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430617

Role of the outward delayed rectifier K+ current in ceramide-induced caspase activation and apoptosis in cultured cortical neurons

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430617

Monocytic cell necrosis is mediated by potassium depletion and caspase-like proteases

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430617

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430617

Genetic demonstration of a role for PKA in the late phase of LTP and in hippocampus-based long-term memory

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430617

Human immunodeficiency virus type 1 tat activates non-N-methyl-D-aspartate excitatory amino acid receptors and causes neurotoxicity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430617

Pivotal role of cerebral interleukin-17-producing gammadeltaT cells in the delayed phase of ischemic brain injury

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430617

Enhancement of neuronal outward delayed rectifier K+ current by human monocyte-derived macrophages

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430617

Granzyme-b mediated cell death in the spinal cord-injured rat model

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430617

Exacerbation of dopaminergic terminal damage in a mouse model of Parkinson's disease by the G-protein-coupled receptor protease-activated receptor 1.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430617

Proteinase-activated receptors 1 and 2 in rat olfactory system: layer-specific regulation of multiple signaling pathways in the main olfactory bulb and induction of neurite retraction in olfactory sensory neurons

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430617

Possible involvement of BDNF release in long-lasting synapse formation induced by repetitive PKA activation.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430617

Potassium channels Kv1.3 and Kv1.5 are expressed on blood-derived dendritic cells in the central nervous system.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430617

Notch-1 immunoexpression is increased in Alzheimer's and Pick's disease.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430617

Fibroblast growth factor 2 applied to the optic nerve after axotomy up-regulates BDNF and TrkB in ganglion cells by activating the ERK and PKA signaling pathways.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430617

Microglia Kv1.3 channels contribute to their ability to kill neurons.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430617

Cyclic AMP controls BDNF-induced TrkB phosphorylation and dendritic spine formation in mature hippocampal neurons

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430617

PAR-1 deficiency protects against neuronal damage and neurologic deficits after unilateral cerebral hypoxia/ischemia

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430617

PAR-1 kinase plays an initiator role in a temporally ordered phosphorylation process that confers tau toxicity in Drosophila

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430617

Involvement of mitochondrial K+ release and cellular efflux in ischemic and apoptotic neuronal death

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430617

Acute axonal damage in multiple sclerosis is most extensive in early disease stages and decreases over time.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430617

Functional significance of cell volume regulatory mechanisms.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430617

Presence of the voltage-gated potassium channels sensitive to charybdotoxin in inhibitory presynaptic terminals of cultured rat hippocampal neurons.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3430617

Thrombin perturbs neurite outgrowth and induces apoptotic cell death in enriched chick spinal motoneuron cultures through caspase activation

27 October 2018

1 reference

12 December 2020

Granzyme B mediates neurotoxicity through a G-protein-coupled receptor

1 reference

12 December 2020

Increased Notch 1 expression and attenuated stimulatory G protein coupling to adenylyl cyclase in osteonectin-null osteoblasts

1 reference

12 December 2020

Vulnerability of human neurons to T cell-mediated cytotoxicity

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0043950

Identifiers

DOI

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2 August 2017

0 references

1 reference

2 August 2017

1 reference