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TGF-beta signaling in cancer--a double-edged sword
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scholarly article
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Europe PubMed Central
PubMed ID
11684442
retrieved
2 August 2017
review article
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Europe PubMed Central
title
TGF-beta signaling in cancer--a double-edged sword
(English)
1 reference
stated in
Europe PubMed Central
PubMed ID
11684442
retrieved
2 August 2017
author name string
Akhurst RJ
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed ID
11684442
retrieved
2 August 2017
Derynck R
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed ID
11684442
retrieved
2 August 2017
publication date
1 November 2001
1 reference
stated in
Europe PubMed Central
PubMed ID
11684442
retrieved
2 August 2017
published in
Trends in Cell Biology
1 reference
stated in
Europe PubMed Central
PubMed ID
11684442
retrieved
2 August 2017
volume
11
1 reference
stated in
Europe PubMed Central
PubMed ID
11684442
retrieved
2 August 2017
issue
11
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stated in
Europe PubMed Central
PubMed ID
11684442
retrieved
2 August 2017
page(s)
S44-51
1 reference
stated in
Europe PubMed Central
PubMed ID
11684442
retrieved
2 August 2017
cites work
Growth factors from murine sarcoma virus-transformed cells
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https://api.crossref.org/works/10.1016%2FS0962-8924%2801%2902130-4
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Selective inhibition of growth-related gene expression in murine keratinocytes by transforming growth factor beta
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Transforming growth factor beta stimulates mammary adenocarcinoma cell invasion and metastatic potential
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TGFbeta1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice
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TGF-beta-induced apoptosis is mediated by the adapter protein Daxx that facilitates JNK activation
1 reference
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Localized production of TGF-β mRNA in tumour promoter-stimulated mouse epidermis
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Concerted action of TGF-beta 1 and its type II receptor in control of epidermal homeostasis in transgenic mice
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Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability
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7 January 2021
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TGFbeta signaling in growth control, cancer, and heritable disorders
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7 January 2021
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A mechanism of repression of TGFbeta/ Smad signaling by oncogenic Ras
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https://api.crossref.org/works/10.1016%2FS0962-8924%2801%2902130-4
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7 January 2021
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Smad4/DPC4 silencing and hyperactive Ras jointly disrupt transforming growth factor-beta antiproliferative responses in colon cancer cells.
1 reference
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https://api.crossref.org/works/10.1016%2FS0962-8924%2801%2902130-4
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7 January 2021
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Raf induces TGFbeta production while blocking its apoptotic but not invasive responses: a mechanism leading to increased malignancy in epithelial cells
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https://api.crossref.org/works/10.1016%2FS0962-8924%2801%2902130-4
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7 January 2021
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TGF-beta1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells
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reference URL
https://api.crossref.org/works/10.1016%2FS0962-8924%2801%2902130-4
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7 January 2021
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High levels of transforming growth factor beta 1 in patients with colorectal cancer: association with disease progression
1 reference
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https://api.crossref.org/works/10.1016%2FS0962-8924%2801%2902130-4
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Transforming growth factor beta1 is associated with angiogenesis, metastasis, and poor clinical outcome in prostate cancer
1 reference
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TGFbeta signaling is necessary for carcinoma cell invasiveness and metastasis
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Evidence that Smad2 is a tumor suppressor implicated in the control of cellular invasion
1 reference
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https://api.crossref.org/works/10.1016%2FS0962-8924%2801%2902130-4
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7 January 2021
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Targeted disruption in murine cells reveals variable requirement for Smad4 in transforming growth factor beta-related signaling.
1 reference
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TGF-beta induces fibronectin synthesis through a c-Jun N-terminal kinase-dependent, Smad4-independent pathway
1 reference
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https://api.crossref.org/works/10.1016%2FS0962-8924%2801%2902130-4
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Cyclosporine induces cancer progression by a cell-autonomous mechanism.
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TGF-beta signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development
1 reference
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https://api.crossref.org/works/10.1016%2FS0962-8924%2801%2902130-4
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7 January 2021
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Epithelial cell plasticity in development and tumor progression
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https://api.crossref.org/works/10.1016%2FS0962-8924%2801%2902130-4
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7 January 2021
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Spindle cell carcinoma.Ultrastructural evidence of squamous origin and collagen production by the tumor cells
1 reference
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https://api.crossref.org/works/10.1016%2FS0962-8924%2801%2902130-4
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7 January 2021
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TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptors
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0962-8924%2801%2902130-4
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7 January 2021
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Effects of transforming growth factor beta on growth of human mammary epithelial cells in culture
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS0962-8924%2801%2902130-4
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Epithelial-mesenchymal transformation of a newly established cell line from ovarian adenosarcoma by transforming growth factor-beta1.
1 reference
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https://api.crossref.org/works/10.1016%2FS0962-8924%2801%2902130-4
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Involvement of the Ras/MAPK signaling pathway in the modulation of urokinase production and cellular invasiveness by transforming growth factor-beta(1) in transformed keratinocytes.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0962-8924%2801%2902130-4
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7 January 2021
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Blockade of Smad4 in transformed keratinocytes containing a Ras oncogene leads to hyperactivation of the Ras-dependent Erk signalling pathway associated with progression to undifferentiated carcinomas
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0962-8924%2801%2902130-4
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7 January 2021
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Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS0962-8924%2801%2902130-4
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7 January 2021
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Enhanced tumorigenicity and invasion-metastasis by hepatocyte growth factor/scatter factor-met signalling in human cells concomitant with induction of the urokinase proteolysis network
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS0962-8924%2801%2902130-4
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Endoglin, a TGF-beta binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS0962-8924%2801%2902130-4
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The activin receptor-like kinase 1 gene: genomic structure and mutations in hereditary hemorrhagic telangiectasia type 2
1 reference
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https://api.crossref.org/works/10.1016%2FS0962-8924%2801%2902130-4
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TGF-beta receptor type II deficiency results in defects of yolk sac hematopoiesis and vasculogenesis
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS0962-8924%2801%2902130-4
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7 January 2021
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Defective angiogenesis in mice lacking endoglin
1 reference
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https://api.crossref.org/works/10.1016%2FS0962-8924%2801%2902130-4
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7 January 2021
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Endoglin, an ancillary TGFbeta receptor, is required for extraembryonic angiogenesis and plays a key role in heart development
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS0962-8924%2801%2902130-4
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7 January 2021
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A murine model of hereditary hemorrhagic telangiectasia
1 reference
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https://api.crossref.org/works/10.1016%2FS0962-8924%2801%2902130-4
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7 January 2021
based on heuristic
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Activin receptor-like kinase 1 modulates transforming growth factor-beta 1 signaling in the regulation of angiogenesis
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0962-8924%2801%2902130-4
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7 January 2021
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Arteriovenous malformations in mice lacking activin receptor-like kinase-1
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https://api.crossref.org/works/10.1016%2FS0962-8924%2801%2902130-4
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7 January 2021
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Abnormal angiogenesis but intact hematopoietic potential in TGF-beta type I receptor-deficient mice
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS0962-8924%2801%2902130-4
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7 January 2021
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A role for smad6 in development and homeostasis of the cardiovascular system
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS0962-8924%2801%2902130-4
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7 January 2021
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Expression of growth factors, growth-inhibiting factors, and their receptors in invasive breast cancer. II: Correlations with proliferation and angiogenesis
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0962-8924%2801%2902130-4
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7 January 2021
based on heuristic
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Positive correlation of plasma transforming growth factor-beta 1 levels with tumor vascularity in hepatocellular carcinoma
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0962-8924%2801%2902130-4
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7 January 2021
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Excessive production of transforming growth-factor beta 1 can play an important role in the development of tumorigenesis by its action for angiogenesis: validity of neutralizing antibodies to block tumor growth
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS0962-8924%2801%2902130-4
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7 January 2021
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Phenotypic modulation of endothelial cells by transforming growth factor-beta depends upon the composition and organization of the extracellular matrix
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS0962-8924%2801%2902130-4
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7 January 2021
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Macrophage-derived angiogenesis factors
1 reference
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https://api.crossref.org/works/10.1016%2FS0962-8924%2801%2902130-4
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7 January 2021
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A highly immunogenic tumor transfected with a murine transforming growth factor type beta 1 cDNA escapes immune surveillance
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS0962-8924%2801%2902130-4
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7 January 2021
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Anti-transforming growth factor (TGF)-beta antibodies inhibit breast cancer cell tumorigenicity and increase mouse spleen natural killer cell activity. Implications for a possible role of tumor cell/host TGF-beta interactions in human breast cancer
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS0962-8924%2801%2902130-4
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7 January 2021
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Regulation of the proinflammatory effects of Fas ligand (CD95L).
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS0962-8924%2801%2902130-4
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7 January 2021
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Transforming growth factor beta 1 (TGF-beta 1) controls expression of major histocompatibility genes in the postnatal mouse: aberrant histocompatibility antigen expression in the pathogenesis of the TGF-beta 1 null mouse phenotype
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0962-8924%2801%2902130-4
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7 January 2021
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Evidence that transforming growth factor-beta is a hormonally regulated negative growth factor in human breast cancer cells
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS0962-8924%2801%2902130-4
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7 January 2021
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Transforming growth factor beta 1 is implicated in the failure of tamoxifen therapy in human breast cancer
1 reference
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https://api.crossref.org/works/10.1016%2FS0962-8924%2801%2902130-4
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7 January 2021
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Blockade of transforming growth factor-beta signaling does not abrogate antiestrogen-induced growth inhibition of human breast carcinoma cells
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS0962-8924%2801%2902130-4
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7 January 2021
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Reversal of tamoxifen resistance of human breast carcinomas in vivo by neutralizing antibodies to transforming growth factor-beta.
1 reference
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7 January 2021
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Transforming growth factor-beta-mediated autocrine growth regulation of gliomas as detected with phosphorothioate antisense oligonucleotides.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0962-8924%2801%2902130-4
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7 January 2021
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Modulation of B16 melanoma growth and metastasis by anti-transforming growth factor beta antibody and interleukin-2
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS0962-8924%2801%2902130-4
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7 January 2021
based on heuristic
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TGFbeta influences Myc, Miz-1 and Smad to control the CDK inhibitor p15INK4b
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0962-8924%2801%2902130-4
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7 January 2021
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Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15(Ink4B) transcription in response to TGF-beta
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0962-8924%2801%2902130-4
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7 January 2021
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Mutation and cancer: statistical study of retinoblastoma
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0962-8924%2801%2902130-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S0962-8924(01)02130-4
1 reference
stated in
Europe PubMed Central
PubMed ID
11684442
retrieved
2 August 2017
PubMed ID
11684442
1 reference
stated in
Europe PubMed Central
PubMed ID
11684442
retrieved
2 August 2017
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