(Q34426453)

English

CYP2C9 genotype-dependent effects on in vitro drug-drug interactions: switching of benzbromarone effect from inhibition to activation in the CYP2C9.3 variant.

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15955872%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

CYP2C9 genotype-dependent effects on in vitro drug-drug interactions: switching of benzbromarone effect from inhibition to activation in the CYP2C9.3 variant (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15955872%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

drug interaction

0 references

Peter M Gannett

3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15955872%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

author name string

Matthew A Hummel

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15955872%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

Charles W Locuson

2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15955872%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

Dan A Rock

4

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15955872%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

Carrie M Mosher

5

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15955872%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

Allan E Rettie

6

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15955872%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

Timothy S Tracy

7

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15955872%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

publication date

13 June 2005

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15955872%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

Molecular Pharmacology

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15955872%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

68

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15955872%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15955872%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

644-651

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15955872%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

Enzymatic determinants of the substrate specificity of CYP2C9: role of B'-C loop residues in providing the pi-stacking anchor site for warfarin binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/15955872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CYP2C9 Ile359 and Leu359 variants: enzyme kinetic study with seven substrates

1 reference

https://pubmed.ncbi.nlm.nih.gov/15955872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Orientation of caffeine within the active site of human cytochrome P450 1A2 based on NMR longitudinal (T1) relaxation measurements

1 reference

https://pubmed.ncbi.nlm.nih.gov/15955872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A kinetic model for the metabolic interaction of two substrates at the active site of cytochrome P450 3A4.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15955872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dapsone activation of CYP2C9-mediated metabolism: evidence for activation of multiple substrates and a two-site model

1 reference

https://pubmed.ncbi.nlm.nih.gov/15955872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification and functional characterization of a new CYP2C9 variant (CYP2C9*5) expressed among African Americans

1 reference

https://pubmed.ncbi.nlm.nih.gov/15955872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polymorphic variants (CYP2C9*3 and CYP2C9*5) and the F114L active site mutation of CYP2C9: effect on atypical kinetic metabolism profiles

1 reference

https://pubmed.ncbi.nlm.nih.gov/15955872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Factors confounding the successful extrapolation of in vitro CYP3A inhibition information to the in vivo condition

1 reference

https://pubmed.ncbi.nlm.nih.gov/15955872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association between CYP2C9 genetic variants and anticoagulation-related outcomes during warfarin therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/15955872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytochrome P450 2C9 polymorphisms: a comprehensive review of the in-vitro and human data.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15955872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of endogenous steroids on CYP3A4-mediated drug metabolism by human liver microsomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15955872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Photochemically catalyzed generation of site-specific 8-nitroguanine adducts in DNA by the reaction of long-lived neutral guanine radicals with nitrogen dioxide.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15955872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quinidine and haloperidol as modifiers of CYP3A4 activity: multisite kinetic model approach

1 reference

https://pubmed.ncbi.nlm.nih.gov/15955872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of cytochrome P450 2C9-mediated metabolism: mechanistic evidence in support of kinetic observations

1 reference

https://pubmed.ncbi.nlm.nih.gov/15955872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A new class of CYP2C9 inhibitors: probing 2C9 specificity with high-affinity benzbromarone derivatives

1 reference

https://pubmed.ncbi.nlm.nih.gov/15955872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rabbit CYP4B1 engineered for high-level expression in Escherichia coli: ligand stabilization and processing of the N-terminus and heme prosthetic group.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15955872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sigmoidal kinetic model for two co-operative substrate-binding sites in a cytochrome P450 3A4 active site: an example of the metabolism of diazepam and its derivatives

1 reference

https://pubmed.ncbi.nlm.nih.gov/15955872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Generation and Evaluation of a CYP2C9 Heteroactivation Pharmacophore

1 reference

https://pubmed.ncbi.nlm.nih.gov/15955872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Crystal structure of human cytochrome P450 2C9 with bound warfarin

1 reference

https://pubmed.ncbi.nlm.nih.gov/15955872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparative studies on the catalytic roles of cytochrome P450 2C9 and its Cys- and Leu-variants in the oxidation of warfarin, flurbiprofen, and diclofenac by human liver microsomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15955872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evaluation of atypical cytochrome P450 kinetics with two-substrate models: evidence that multiple substrates can simultaneously bind to cytochrome P450 active sites

1 reference

https://pubmed.ncbi.nlm.nih.gov/15955872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential roles of Arg97, Asp293, and Arg108 in enzyme stability and substrate specificity of CYP2C9.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15955872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential activation of CYP2C9 variants by dapsone

1 reference

https://pubmed.ncbi.nlm.nih.gov/15955872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitative binding models for CYP2C9 based on benzbromarone analogues

1 reference

https://pubmed.ncbi.nlm.nih.gov/15955872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effector-mediated alteration of substrate orientation in cytochrome P450 2C9.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15955872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High-throughput screening assays for the assessment of CYP2C9*1, CYP2C9*2, and CYP2C9*3 metabolism using fluorogenic Vivid substrates.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15955872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The structure of human cytochrome P450 2C9 complexed with flurbiprofen at 2.0-A resolution

1 reference

https://pubmed.ncbi.nlm.nih.gov/15955872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nuclear relaxation measurements of the geometry of enzyme-bound substrates and analogs.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15955872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression and enzymatic activity of recombinant cytochrome P450 17 alpha-hydroxylase in Escherichia coli

1 reference

https://pubmed.ncbi.nlm.nih.gov/15955872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of CYP3A4: evidence for the simultaneous binding of two substrates in a cytochrome P450 active site.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15955872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of cytochrome P450 2C9 and an allelic variant in the 4'-hydroxylation of (R)- and (S)-flurbiprofen

1 reference

https://pubmed.ncbi.nlm.nih.gov/15955872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A model for human cytochrome P450 2D6 based on homology modeling and NMR studies of substrate binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/15955872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Allelic variants of human cytochrome P450 2C9: baculovirus-mediated expression, purification, structural characterization, substrate stereoselectivity, and prochiral selectivity of the wild-type and I359L mutant forms.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15955872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studies of flurbiprofen 4'-hydroxylation. Additional evidence suggesting the sole involvement of cytochrome P450 2C9.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15955872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Substrate Binding Site of Human Liver Cytochrome P450 2C9: An NMR Study†

1 reference

https://pubmed.ncbi.nlm.nih.gov/15955872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic association between sensitivity to warfarin and expression of CYP2C9*3

1 reference

https://pubmed.ncbi.nlm.nih.gov/15955872

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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