(Q34430634)

2 August 2017

title

Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis (English)

1 reference

Corrigendum: Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis

2 August 2017

corrigendum / erratum

1 reference

12 July 2019

http://api.crossref.org/works?select=update-to&filter=doi:10.1038/NCOMMS7542

author

Tõnu Esko

2

1 reference

2 August 2017

23

1 reference

2 August 2017

46

1 reference

2 August 2017

65

1 reference

2 August 2017

40

Gérard Waeber

0 references

Peter Vollenweider

54

Peter Vollenweider

0 references

Konrad Oexle

64

Konrad Oexle

0 references

Serena Sanna

13

Serena Sanna

0 references

Andres Metspalu

66

Andres Metspalu

0 references

Manuela Uda

53

Manuela Uda

0 references

Claudia Langenberg

56

Claudia Langenberg

0 references

Melanie Waldenberger

26

Melanie Waldenberger

0 references

Harm-Jan Westra

17

Harm-Jan Westra

0 references

Pim van der Harst

52

Pim van der Harst

1 reference

2 August 2017

34

Irene Pichler

1 reference

2 August 2017

41

Niek Verweij

0 references

Clara Podmore

Clara Podmore

10

0 references

Aparna Radhakrishnan

Aparna Radhakrishnan

4

0 references

Maristella Steri

Maristella Steri

39

0 references

Denise Anderson

Denise Anderson

8

0 references

Fudi Wang

Fudi Wang

16

0 references

Beben Benyamin

Beben Benyamin

1

0 references

Augusto Rendon

Augusto Rendon

27

0 references

Lili Milani

Lili Milani

20

0 references

Andrew A Hicks

Andrew A Hicks

62

0 references

Juliane Winkelmann

Juliane Winkelmann

22

0 references

Willem H. Ouwehand

Willem H Ouwehand

63

0 references

Najaf Amin

Najaf Amin

38

0 references

Lude Franke

Lude Franke

18

0 references

John Beilby

John Beilby

60

0 references

Margaret J. Wright

Margaret J Wright

47

0 references

Fred Sweep

Fred C Sweep

31

0 references

Annette Peters

Annette Peters

25

0 references

Grant W. Montgomery

Grant W Montgomery

48

0 references

Lambertus Kiemeney

Lambertus A Kiemeney

30

0 references

Nick Martin

Nicholas G Martin

49

0 references

Dale R Nyholt

Dale R Nyholt

43

0 references

Ayşe Demirkan

Ayse Demirkan

36

0 references

Nicholas J. Wareham

57

Nicholas J Wareham

1 reference

2 August 2017

Cornelia M. van Duijn

59

Cornelia van Duijn

1 reference

2 August 2017

24

Joachim Thiery

1 reference

2 August 2017

51

Stefania Bandinelli

1 reference

2 August 2017

45

Pamela A F Madden

1 reference

2 August 2017

44

Andrew C Heath

1 reference

2 August 2017

12

Zoltan Kutalik

1 reference

2 August 2017

19

Evelin Mihailov

1 reference

2 August 2017

50

Dena Hernandez

1 reference

2 August 2017

70

John B Whitfield

1 reference

2 August 2017

42

Joseph E Powell

1 reference

2 August 2017

61

Peter P Pramstaller

1 reference

2 August 2017

35

Jennie Hui

1 reference

2 August 2017

5

Sita H Vermeulen

1 reference

2 August 2017

58

InterAct Consortium

1 reference

2 August 2017

3

Janina S Ried

1 reference

2 August 2017

6

Michela Traglia

1 reference

2 August 2017

7

Martin Gögele

1 reference

2 August 2017

9

Linda Broer

1 reference

2 August 2017

21

Jonas Hälldin

1 reference

2 August 2017

28

Jennifer Jolley

1 reference

2 August 2017

29

Jennifer Sambrook

1 reference

2 August 2017

32

Cinzia F Sala

1 reference

2 August 2017

Christine Schwienbacher

33

Christine Schwienbacher

1 reference

2 August 2017

37

Aaron Isaacs

1 reference

2 August 2017

68

Daniela Toniolo

1 reference

2 August 2017

69

Dorine W Swinkels

1 reference

2 August 2017

Jian'an Luan

11

1 reference

2 August 2017

Peter van der Meer

14

1 reference

2 August 2017

Toshiko Tanaka

15

1 reference

2 August 2017

Robert A Scott

55

1 reference

2 August 2017

Clara Camaschella

67

1 reference

2 August 2017

language of work or name

English

0 references

publication date

29 October 2014

1 reference

2 August 2017

published in

Nature Communications

1 reference

2 August 2017

volume

5

1 reference

2 August 2017

page(s)

4926

1 reference

A multi-scale model of hepcidin promoter regulation reveals factors controlling systemic iron homeostasis

2 August 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215164

Unbiased RNAi screen for hepcidin regulators links hepcidin suppression to proliferative Ras/RAF and nutrient-dependent mTOR signaling

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215164

Genetic and biochemical markers in patients with Alzheimer's disease support a concerted systemic iron homeostasis dysregulation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215164

Pooled analysis of iron-related genes in Parkinson's disease: association with transferrin

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215164

Discovery and refinement of loci associated with lipid levels

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215164

Systematic identification of trans eQTLs as putative drivers of known disease associations

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215164

Total mortality by elevated transferrin saturation in patients with diabetes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215164

Serum iron levels and the risk of Parkinson disease: a Mendelian randomization study

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215164

Iron deficiency anemia: a common and curable disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215164

6 July 2018

Iron and diabetes risk

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215164

Ferritin levels and risk of type 2 diabetes mellitus: an updated systematic review and meta-analysis of prospective evidence.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215164

Seventy-five genetic loci influencing the human red blood cell

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215164

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215164

Interactions between hepatic iron and lipid metabolism with possible relevance to steatohepatitis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215164

mTOR signaling in growth control and disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215164

Hemoglobin directs macrophage differentiation and prevents foam cell formation in human atherosclerotic plaques

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215164

Pharmacological suppression of hepcidin increases macrophage cholesterol efflux and reduces foam cell formation and atherosclerosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215164

Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215164

Human metabolic individuality in biomedical and pharmaceutical research

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215164

Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215164

Mass spectrometry analysis of hepcidin peptides in experimental mouse models

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215164

Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215164

Mutant HFE H63D protein is associated with prolonged endoplasmic reticulum stress and increased neuronal vulnerability

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215164

HFE gene variants affect iron in the brain

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215164

Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215164

Diagnosis and management of hereditary haemochromatosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215164

Identification of a common variant in the TFR2 gene implicated in the physiological regulation of serum iron levels

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215164

Iron promotes the toxicity of amyloid beta peptide by impeding its ordered aggregation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215164

Iron overload in thalassemia and related conditions: therapeutic goals and assessment of response to chelation therapies

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215164

Iron and immunity: immunological consequences of iron deficiency and overload

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215164

Genetic variants influencing circulating lipid levels and risk of coronary artery disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215164

Biological, clinical and population relevance of 95 loci for blood lipids

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215164

METAL: fast and efficient meta-analysis of genomewide association scans

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215164

Two to tango: regulation of Mammalian iron metabolism

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215164

A versatile gene-based test for genome-wide association studies

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215164

Genetic variation in lipid desaturases and its impact on the development of human disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215164

Detailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215164

Genetic variants in ABO blood group region, plasma soluble E-selectin levels and risk of type 2 diabetes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215164

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215164

Genetic mechanisms and modifying factors in hereditary hemochromatosis.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215164

Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215164

Heritability and demographic analyses in the large isolated population of Val Borbera suggest advantages in mapping complex traits genes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215164

Common variants in TMPRSS6 are associated with iron status and erythrocyte volume

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215164

Genome-wide association study identifies variants in TMPRSS6 associated with hemoglobin levels

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215164

A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215164

Interaction of the hereditary hemochromatosis protein HFE with transferrin receptor 2 is required for transferrin-induced hepcidin expression

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215164

Common variants at 30 loci contribute to polygenic dyslipidemia

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215164

Diurnal cycle influences peripheral and brain iron levels in mice

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215164

Establishing an adjusted p-value threshold to control the family-wide type 1 error in genome wide association studies

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215164

Mapping the genetic architecture of gene expression in human liver

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215164

Iron-overload-related disease in HFE hereditary hemochromatosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215164

Role of iron in hepatic fibrosis: one piece in the puzzle

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215164

An overview of evidence for a causal relation between iron deficiency during development and deficits in cognitive or behavioral function

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215164

Hereditary hemochromatosis protein, HFE, interaction with transferrin receptor 2 suggests a molecular mechanism for mammalian iron sensing

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215164

Screening for hereditary hemochromatosis: a systematic review for the U.S. Preventive Services Task Force

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215164

Hereditary hemochromatosis: genetic complexity and new diagnostic approaches

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215164

Hemochromatosis and iron-overload screening in a racially diverse population.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215164

Penetrance of 845G--> A (C282Y) HFE hereditary haemochromatosis mutation in the USA.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215164

Effects of HFE C282Y and H63D polymorphisms and polygenic background on iron stores in a large community sample of twins

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215164

Serum transferrin receptor: a quantitative measure of tissue iron deficiency.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215164

Correlation between serum ferritin levels and liver iron concentration determined by MR imaging: impact of hematologic disease and inflammation.

6 July 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5926

Transferrin receptor 2 is a component of the erythropoietin receptor complex and is required for efficient erythropoiesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5926

Influences of sleep and the circadian rhythm on iron-status indices

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5926

Diurnal rhythm rather than dietary iron mediates daily hepcidin variations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5926

Circadian rhythm of transferrin receptor 1 gene expression controlled by c-Myc in colon cancer-bearing mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5926

Combined deletion of Hfe and transferrin receptor 2 in mice leads to marked dysregulation of hepcidin and iron overload.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5926

Hereditary hemochromatosis: effect of excessive alcohol consumption on disease expression in patients homozygous for the C282Y mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5926

Total mortality by transferrin saturation levels: two general population studies and a metaanalysis

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25352340

12 December 2020

inferred from PubMed ID database lookup

Juvenile hemochromatosis associated with pathogenic mutations of adult hemochromatosis genes

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25352340

12 December 2020

inferred from PubMed ID database lookup

Hypocholesterolemia in chronic anemias with increased erythropoietic activity

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25352340

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1038/NCOMMS5926

1 reference

Dimensions Publication ID

2 August 2017

0 references

1004320473

0 references

Fatcat ID

release_mgm5yhcik5avvpaugsiqt6mlym

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/mgm5yhcik5avvpaugsiqt6mlym

24 November 2022

mapped directly with Wikidata item

PMC publication ID

4215164

1 reference

2 August 2017

1 reference