(Q37633932)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19918260%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

review article

1 reference

title

Genetic mechanisms and modifying factors in hereditary hemochromatosis (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19918260%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19918260%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

author name string

Günter Weiss

series ordinal

1

1 reference

21 August 2017

language of work or name

English

0 references

publication date

17 November 2009

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19918260%20AND%20SRC:MED&resulttype=core&format=json

Nature Reviews Gastroenterology & Hepatology

12 February 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19918260%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

volume

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19918260%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

issue

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19918260%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

page(s)

50-58

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19918260%20AND%20SRC:MED&resulttype=core&format=json

The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation

12 February 2020

cites work

1 reference

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Iron overload and cofactors with special reference to alcohol, hepatitis C virus infection and steatosis/insulin resistance

21 January 2018

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Co-factors in liver disease: the role of HFE-related hereditary hemochromatosis and iron

21 January 2018

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Hereditary hemochromatosis in the post-HFE era

21 January 2018

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Hereditary hemochromatosis--a new look at an old disease

31 March 2020

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31 March 2020

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HFE and non-HFE hemochromatosis

31 March 2020

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A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis

31 March 2020

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Current approach to hemochromatosis

31 March 2020

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Iron, hemochromatosis, and hepatocellular carcinoma

31 March 2020

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Clinical penetrance of hereditary hemochromatosis

31 March 2020

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Balancing acts: molecular control of mammalian iron metabolism

31 March 2020

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Iron loading and erythrophagocytosis increase ferroportin 1 (FPN1) expression in J774 macrophages.

31 March 2020

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Sequential regulation of ferroportin expression after erythrophagocytosis in murine macrophages: early mRNA induction by haem, followed by iron-dependent protein expression

31 March 2020

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The orchestration of body iron intake: how and where do enterocytes receive their cues?

31 March 2020

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Assessment of the role of nonheme-iron availability in iron balance

31 March 2020

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Identification of an intestinal heme transporter

31 March 2020

1 reference

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Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption

31 March 2020

1 reference

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Cloning and characterization of a mammalian proton-coupled metal-ion transporter

31 March 2020

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Expression of the duodenal iron transporters divalent-metal transporter 1 and ferroportin 1 in iron deficiency and iron overload

31 March 2020

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The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis

31 March 2020

1 reference

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Regulatory networks for the control of body iron homeostasis and their dysregulation in HFE mediated hemochromatosis

31 March 2020

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Posttranslational processing of hepcidin in human hepatocytes is mediated by the prohormone convertase furin

31 March 2020

1 reference

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Hepcidin, a urinary antimicrobial peptide synthesized in the liver

31 March 2020

1 reference

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A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

A mouse model of juvenile hemochromatosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

Different regulatory elements are required for response of hepcidin to interleukin-6 and bone morphogenetic proteins 4 and 9.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

Lack of the bone morphogenetic protein BMP6 induces massive iron overload

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

Iron-Induced Expression of Bone Morphogenic Protein 6 in Intestinal Cells Is the Main Regulator of Hepatic Hepcidin Expression In Vivo

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

Hemojuvelin-neogenin interaction is required for bone morphogenic protein-4-induced hepcidin expression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

Hemojuvelin N-terminal mutants reach the plasma membrane but do not activate the hepcidin response

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

Screening hepcidin for mutations in juvenile hemochromatosis: identification of a new mutation (C70R)

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

A new mutation in the hepcidin promoter impairs its BMP response and contributes to a severe phenotype in HFE related hemochromatosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

Bone morphogenetic protein (BMP)-responsive elements located in the proximal and distal hepcidin promoter are critical for its response to HJV/BMP/SMAD.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

Crystal structure of the hereditary haemochromatosis protein HFE complexed with transferrin receptor

31 March 2020

1 reference

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The clinical relevance of compound heterozygosity for the C282Y and H63D substitutions in hemochromatosis

31 March 2020

1 reference

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HFE based re-evaluation of heterozygous hemochromatosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

HFE C282Y/H63D compound heterozygotes are at low risk of hemochromatosis-related morbidity

31 March 2020

1 reference

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The role of Hfe in transferrin-bound iron uptake by hepatocytes

31 March 2020

1 reference

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Hfe acts in hepatocytes to prevent hemochromatosis.

31 March 2020

1 reference

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The transferrin receptor modulates Hfe-dependent regulation of hepcidin expression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

Interaction of the hereditary hemochromatosis protein HFE with transferrin receptor 2 is required for transferrin-induced hepcidin expression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

Hepcidin is decreased in TFR2 hemochromatosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

Targeted mutagenesis of the murine transferrin receptor-2 gene produces hemochromatosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

BMP/Smad signaling is not enhanced in Hfe-deficient mice despite increased Bmp6 expression.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

Bone morphogenetic protein signaling is impaired in an HFE knockout mouse model of hemochromatosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

Cross-talk between the mitogen activated protein kinase and bone morphogenetic protein/hemojuvelin pathways is required for the induction of hepcidin by holotransferrin in primary mouse hepatocytes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

Combined deletion of Hfe and transferrin receptor 2 in mice leads to marked dysregulation of hepcidin and iron overload.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

Juvenile hemochromatosis associated with pathogenic mutations of adult hemochromatosis genes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

Regulation of hepcidin and iron-overload disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

Resistance to hepcidin is conferred by hemochromatosis-associated mutations of ferroportin

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

Autosomal-dominant hemochrom-atosis is associated with a mutation in the ferroportin (SLC11A3) gene

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

Iron overload in Africans and African-Americans and a common mutation in the SCL40A1 (ferroportin 1) gene

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

A mutation in SLC11A3 is associated with autosomal dominant hemochromatosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

Iron overload in the Asian community.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

Hemochromatosis and iron-overload screening in a racially diverse population.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

A novel mutation in ferroportin1 is associated with haemochromatosis in a Solomon Islands patient

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

A novel mutation in ferroportin implicated in iron overload

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

Survival advantage of the hemochromatosis C282Y mutation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

Pathways for the regulation of interferon-gamma-inducible genes by iron in human monocytic cells.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

Absence of functional Hfe protects mice from invasive Salmonella enterica serovar Typhimurium infection via induction of lipocalin-2.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

Hereditary hemochromatosis results in decreased iron acquisition and growth by Mycobacterium tuberculosis within human macrophages

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

Genetic screening for HFE hemochromatosis in 6,020 Danish men: penetrance of C282Y, H63D, and S65C variants.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

The natural history of serum iron indices for HFE C282Y homozygosity associated with hereditary hemochromatosis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

Clinical consequences of iron overload in hemochromatosis homozygotes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

Hemochromatosis mutations in the general population: iron overload progression rate

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

Iron-overload-related disease in HFE hereditary hemochromatosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

Environmental and genetic modifiers of the progression to fibrosis and cirrhosis in hemochromatosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

Inactivation of the hemochromatosis gene differentially regulates duodenal expression of iron-related mRNAs between mouse strains

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

Genes that modify the hemochromatosis phenotype in mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

Duodenal HFE expression and hepcidin levels determine body iron homeostasis: modulation by genetic diversity and dietary iron availability

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

Mutations in HAMP and HJV genes and their impact on expression of clinical hemochromatosis in a cohort of 100 Spanish patients homozygous for the C282Y mutation of HFE gene.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

Common variants in the BMP2, BMP4, and HJV genes of the hepcidin regulation pathway modulate HFE hemochromatosis penetrance

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

Association of ferroportin Q248H polymorphism with elevated levels of serum ferritin in African Americans in the Hemochromatosis and Iron Overload Screening (HEIRS) Study

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

The serine protease TMPRSS6 is required to sense iron deficiency

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

The serine protease matriptase-2 (TMPRSS6) inhibits hepcidin activation by cleaving membrane hemojuvelin

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

Contribution of STAT3 and SMAD4 pathways to the regulation of hepcidin by opposing stimuli.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

SNP selection for genes of iron metabolism in a study of genetic modifiers of hemochromatosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

Mechanisms for copper acquisition, distribution and regulation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

Genetic study of variation in normal mouse iron homeostasis reveals ceruloplasmin as an HFE-hemochromatosis modifier gene.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

Haptoglobin modifies the hemochromatosis phenotype in mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

A novel association between a SNP in CYBRD1 and serum ferritin levels in a cohort study of HFE hereditary haemochromatosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

Intestinal hypoxia-inducible transcription factors are essential for iron absorption following iron deficiency

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

HIF-2alpha, but not HIF-1alpha, promotes iron absorption in mice.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

Alcohol metabolism-mediated oxidative stress down-regulates hepcidin transcription and leads to increased duodenal iron transporter expression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

Effects of alcohol consumption on iron metabolism in mice with hemochromatosis mutations.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

Hyperferritinemia, iron overload, and multiple metabolic alterations identify patients at risk for nonalcoholic steatohepatitis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

Hepatic iron and nonalcoholic fatty liver disease.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

Pathways underlying iron accumulation in human nonalcoholic fatty liver disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

Severity of iron overload of proband determines serum ferritin levels in families with HFE-related hemochromatosis: the HEmochromatosis FAmily Study

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

Steatosis is a cofactor in liver injury in hemochromatosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

Blunted hepcidin response to oral iron challenge in HFE-related hemochromatosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

Copper availability contributes to iron perturbations in human nonalcoholic fatty liver disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

Inhibition of iron absorption by omeprazole in rat model

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

Proton pump inhibitors suppress absorption of dietary non-haem iron in hereditary haemochromatosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

Ca2+ channel blockers reverse iron overload by a new mechanism via divalent metal transporter-1

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

Hepatitis C virus-induced reactive oxygen species raise hepatic iron level in mice by reducing hepcidin transcription

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

Hepatitis C, iron status, and disease severity: relationship with HFE mutations

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

Hemochromatosis and transferrin receptor gene polymorphisms in chronic hepatitis C: impact on iron status, liver injury and HCV genotype.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

The relation of iron status and hemochromatosis gene mutations in patients with chronic hepatitis C

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

Regulation of iron homeostasis in anemia of chronic disease and iron deficiency anemia: diagnostic and therapeutic implications.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

Rapid responses to oxidative stress mediated by iron regulatory protein.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

Differences in hepatic phenotype between hemochromatosis patients with HFE C282Y homozygosity and other HFE genotypes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

New pharmacological concepts for the treatment of iron overload disorders

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2009.201

Intestinal iron absorption in chronic alcoholics

31 March 2020

1 reference

12 December 2020

Inappropriately high iron regulatory protein activity in monocytes of patients with genetic hemochromatosis

1 reference

12 December 2020

Autosomal-dominant hemochromatosis is associated with a mutation in the ferroportin (SLC11A3) gene

1 reference

12 December 2020

Noncitrus fruits as novel dietary environmental modifiers of iron stores in people with or without HFE gene mutations.

1 reference

12 December 2020