(Q34449990)

2 August 2017

title

Amyloid beta-protein is degraded by cellular angiotensin-converting enzyme (ACE) and elevated by an ACE inhibitor (English)

1 reference

2 August 2017

2

Dennis J Selkoe

1 reference

2 August 2017

Matthew L Hemming

1

1 reference

2 August 2017

language of work or name

English

0 references

publication date

9 September 2005

1 reference

Journal of Biological Chemistry

2 August 2017

published in

1 reference

2 August 2017

volume

280

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2 August 2017

issue

45

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2 August 2017

page(s)

37644-37650

1 reference

Large meta-analysis establishes the ACE insertion-deletion polymorphism as a marker of Alzheimer's disease

2 August 2017

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Signaling via the angiotensin-converting enzyme enhances the expression of cyclooxygenase-2 in endothelial cells.

6 July 2018

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Alternative translation initiation generates a novel isoform of insulin-degrading enzyme targeted to mitochondria

6 July 2018

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Angiotensin-converting enzyme is involved in outside-in signaling in endothelial cells

6 July 2018

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6 July 2018

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Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo

6 July 2018

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Alzheimer's disease beta-amyloid peptide is increased in mice deficient in endothelin-converting enzyme

6 July 2018

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Epitope-specific antibody-induced cleavage of angiotensin-converting enzyme from the cell surface

6 July 2018

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Angiotensin-converting enzyme degrades Alzheimer amyloid beta-peptide (A beta ); retards A beta aggregation, deposition, fibril formation; and inhibits cytotoxicity

6 July 2018

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Shedding of somatic angiotensin-converting enzyme (ACE) is inefficient compared with testis ACE despite cleavage at identical stalk sites.

6 July 2018

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Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme

6 July 2018

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Substrate dependence of angiotensin I-converting enzyme inhibition: captopril displays a partial selectivity for inhibition of N-acetyl-seryl-aspartyl-lysyl-proline hydrolysis compared with that of angiotensin I.

6 July 2018

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Amyloid precursor protein processing and A beta42 deposition in a transgenic mouse model of Alzheimer disease

6 July 2018

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The broad substrate specificity of human angiotensin I converting enzyme

6 July 2018

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An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels

6 July 2018

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The two homologous domains of human angiotensin I-converting enzyme are both catalytically active

6 July 2018

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Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

6 July 2018

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The two homologous domains of human angiotensin I-converting enzyme interact differently with competitive inhibitors

6 July 2018

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ACE gene is associated with Alzheimer's disease and atrophy of hippocampus and amygdala.

6 July 2018

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Alternative splicing of human insulin-degrading enzyme yields a novel isoform with a decreased ability to degrade insulin and amyloid beta-protein

27 October 2018

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The N-terminal active centre of human angiotensin-converting enzyme degrades Alzheimer amyloid beta-peptide.

27 October 2018

1 reference

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ACE I/D polymorphism is a risk factor of Alzheimer's disease but not of vascular dementia.

27 October 2018

1 reference

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A cladistic model of ACE sequence variation with implications for myocardial infarction, Alzheimer disease and obesity

27 October 2018

1 reference

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Alzheimer disease risk and genetic variation in ACE: a meta-analysis

27 October 2018

1 reference

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Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death

27 October 2018

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Evidence for the negative cooperativity of the two active sites within bovine somatic angiotensin-converting enzyme

27 October 2018

1 reference

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Antibodies against beta-amyloid slow cognitive decline in Alzheimer's disease

27 October 2018

1 reference

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The angiotensin 1-converting enzyme insertion (I)/deletion (D) polymorphism does not influence the extent of amyloid or tau pathology in patients with sporadic Alzheimer's disease

27 October 2018

1 reference

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Cortical alterations of angiotensin converting enzyme, angiotensin II and AT1 receptor in Alzheimer's dementia

27 October 2018

1 reference

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Metabolic regulation of brain Abeta by neprilysin

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2409196

Angiotensin Converting Enzyme in Alzheimer's Disease: Increased Activity in Caudate Nucleus and Cortical Areas

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2409196

Isolation of two differentially glycosylated forms of peptidyl-dipeptidase A (angiotensin converting enzyme) from pig brain: a re-evaluation of their role in neuropeptide metabolism

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2409196

Angiotensin converting enzyme density is increased in temporal cortex from patients with Alzheimer's disease

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2409196

Role of the N-terminal Catalytic Domain of Angiotensin-converting Enzyme Investigated by Targeted Inactivation in Mice

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2409196

Variation in DCP1, encoding ACE, is associated with susceptibility to Alzheimer disease

9 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2409196

The plasmin system is induced by and degrades amyloid-beta aggregates

9 December 2018

1 reference

12 December 2020

Mice Lacking Endothelial Angiotensin-Converting Enzyme Have a Normal Blood Pressure

1 reference

12 December 2020

Plasmin deficiency does not alter endogenous murine amyloid beta levels in mice

1 reference

12 December 2020

An improved fluorometric assay of rat serum and plasma converting enzyme

1 reference

12 December 2020

Proteolytic release of human angiotensin-converting enzyme. Localization of the cleavage site

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M508460200

1 reference

2 August 2017

1 reference

2 August 2017

1 reference