(Q34455805)

2 August 2017

Thiopurine analogs and mycophenolic acid synergistically inhibit the papain-like protease of Middle East respiratory syndrome coronavirus (English)

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Middle East respiratory syndrome coronavirus

2 August 2017

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Middle East

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6-thioguanine

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Middle East respiratory syndrome

ChEBI release 2020-05-28

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1 reference

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25542975%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Chi-Yuan Chou

8

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12 June 2020

author name string

Kai-Wen Cheng

1

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12 June 2020

Shu-Chun Cheng

2

1 reference

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12 June 2020

Min-Han Lin

4

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12 June 2020

Shang-Ju Chuang

5

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12 June 2020

I-Hsin Cheng

6

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12 June 2020

Chiao-Yin Sun

7

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12 June 2020

publication date

24 December 2014

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2 August 2017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25542975%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

volume

115

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12 June 2020

page(s)

9-16

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Synthesis and biological evaluation of α-ketoamides as inhibitors of the Dengue virus protease with antiviral activity in cell-culture

12 June 2020

cites work

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12 December 2020

Crystal structure of the Middle East respiratory syndrome coronavirus (MERS-CoV) papain-like protease bound to ubiquitin facilitates targeted disruption of deubiquitinating activity to demonstrate its role in innate immune suppression

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12 December 2020

Fifteen years of HIV Protease Inhibitors: raising the barrier to resistance

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12 December 2020

Pharmacokinetic interaction between the hepatitis C virus protease inhibitor boceprevir and cyclosporine and tacrolimus in healthy volunteers

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12 December 2020

STUDIES ON LIVER ALCOHOL HYDROGENASE COMPLEXES. 3. MULTIPLE INHIBITION KINETICS IN THE PRESENCE OF TWO COMPETITIVE INHIBITORS

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12 December 2020

Broad-spectrum antivirals for the emerging Middle East respiratory syndrome coronavirus

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12 December 2020

Identification of active antiviral compounds against a New York isolate of West Nile virus

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12 December 2020

Differential domain structure stability of the severe acute respiratory syndrome coronavirus papain-like protease

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12 December 2020

6-thioguanine: a drug with unrealized potential for cancer therapy

1 reference

12 December 2020

Emerging human coronaviruses--disease potential and preparedness

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12 December 2020

Middle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: a comparative serological study.

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12 December 2020

The predominant mechanism by which ribavirin exerts its antiviral activity in vitro against flaviviruses and paramyxoviruses is mediated by inhibition of IMP dehydrogenase

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12 December 2020

Is the discovery of the novel human betacoronavirus 2c EMC/2012 (HCoV-EMC) the beginning of another SARS-like pandemic?

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12 December 2020

Cellular IMPDH enzyme activity is a potential target for the inhibition of Chikungunya virus replication and virus induced apoptosis in cultured mammalian cells

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12 December 2020

Middle East respiratory syndrome coronavirus (MERS-CoV): announcement of the Coronavirus Study Group

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12 December 2020

Thiopurine analogue inhibitors of severe acute respiratory syndrome-coronavirus papain-like protease, a deubiquitinating and deISGylating enzyme

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12 December 2020

Development of Broad-Spectrum Halomethyl Ketone Inhibitors Against Coronavirus Main Protease 3CLpro

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12 December 2020

Peptide aldehyde inhibitors challenge the substrate specificity of the SARS-coronavirus main protease

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12 December 2020

Severe Acute Respiratory Syndrome Coronavirus Papain-like Novel Protease Inhibitors: Design, Synthesis, Protein−Ligand X-ray Structure and Biological Evaluation

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12 December 2020

Structural basis for catalysis and ubiquitin recognition by the severe acute respiratory syndrome coronavirus papain-like protease

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12 December 2020

Middle East respiratory syndrome coronavirus in dromedary camels: an outbreak investigation

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12 December 2020

Mycophenolic acid inhibits dengue virus infection by preventing replication of viral RNA.

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12 December 2020

A structural view of the inactivation of the SARS coronavirus main proteinase by benzotriazole esters

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12 December 2020

Structural and functional characterization of MERS coronavirus papain-like protease

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12 December 2020

Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia

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12 December 2020

Stable Benzotriazole Esters as Mechanism-Based Inactivators of the Severe Acute Respiratory Syndrome 3CL Protease

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12 December 2020

Antiviral or proviral action of mycophenolic acid in hepatitis B infection?

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12 December 2020

Deubiquitinating and interferon antagonism activities of coronavirus papain-like proteases.

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12 December 2020

Close relative of human Middle East respiratory syndrome coronavirus in bat, South Africa

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12 December 2020

Coronavirus main proteinase (3CLpro) structure: basis for design of anti-SARS drugs

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12 December 2020

DNA inhibits catalysis by the carboxyltransferase subunit of acetyl-CoA carboxylase: implications for active site communication.

1 reference

12 December 2020

Aprotinin and similar protease inhibitors as drugs against influenza

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12 December 2020

The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor

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12 December 2020

Mycophenolic acid inhibits replication of Japanese encephalitis virus

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12 December 2020

Proteolytic processing and deubiquitinating activity of papain-like proteases of human coronavirus NL63

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12 December 2020

PLP2, a potent deubiquitinase from murine hepatitis virus, strongly inhibits cellular type I interferon production

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12 December 2020

From SARS to MERS: 10 years of research on highly pathogenic human coronaviruses

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12 December 2020

Thiopurine analogues inhibit papain-like protease of severe acute respiratory syndrome coronavirus.

1 reference

12 December 2020

Enhancement of the infectivity of SARS-CoV in BALB/c mice by IMP dehydrogenase inhibitors, including ribavirin.

1 reference

12 December 2020

Hospital outbreak of Middle East respiratory syndrome coronavirus

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12 December 2020

Assessing activity and inhibition of Middle East respiratory syndrome coronavirus papain-like and 3C-like proteases using luciferase-based biosensors

1 reference

12 December 2020

Synergistic inhibitor binding to the papain-like protease of human SARS coronavirus: mechanistic and inhibitor design implications

1 reference

12 December 2020

In-vitro renal epithelial cell infection reveals a viral kidney tropism as a potential mechanism for acute renal failure during Middle East Respiratory Syndrome (MERS) Coronavirus infection

1 reference

12 December 2020

Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label, randomised, multicentre phase 2 trial

1 reference

12 December 2020

Ecology, evolution and classification of bat coronaviruses in the aftermath of SARS.

1 reference

12 December 2020

Thiopurines in current medical practice: molecular mechanisms and contributions to therapy-related cancer

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12 December 2020

Crystal structure of the papain-like protease of MERS coronavirus reveals unusual, potentially druggable active-site features

1 reference

12 December 2020

Proteolytic processing, deubiquitinase and interferon antagonist activities of Middle East respiratory syndrome coronavirus papain-like protease

1 reference

12 December 2020

10.1016/J.ANTIVIRAL.2014.12.011

Identifiers

DOI

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12 June 2020

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12 June 2020

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