(Q34457712)

2 August 2017

title

Genomic discovery of potent chromatin insulators for human gene therapy (English)

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2 August 2017

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John Stamatoyannopoulos

8

object named as

John A Stamatoyannopoulos

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2 August 2017

Mingdong Liu

1

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2 August 2017

Matthew T Maurano

2

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2 August 2017

Hao Wang

3

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2 August 2017

Heyuan Qi

4

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2 August 2017

Chao-Zhong Song

5

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2 August 2017

Patrick A Navas

6

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2 August 2017

David W Emery

7

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2 August 2017

George Stamatoyannopoulos

9

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2 August 2017

publication date

12 January 2015

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2 August 2017

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2 August 2017

volume

33

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2 August 2017

issue

2

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2 August 2017

page(s)

198-203

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https://scigraph.springernature.com/pub.10.1038/nbt.3062

2 August 2017

exact match

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cites work

Efficacy of gene therapy for X-linked severe combined immunodeficiency

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Gene therapy for immunodeficiency due to adenosine deaminase deficiency.

21 January 2018

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Hematopoietic stem cell gene therapy with a lentiviral vector in X-linked adrenoleukodystrophy

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Transfusion independence and HMGA2 activation after gene therapy of human β-thalassaemia

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Concise review: managing genotoxicity in the therapeutic modification of stem cells

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Genotoxicity of retroviral integration in hematopoietic cells.

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The use of chromatin insulators to improve the expression and safety of integrating gene transfer vectors

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Insulators: exploiting transcriptional and epigenetic mechanisms

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Characterization of the chicken beta-globin insulator

21 January 2018

1 reference

A 5' element of the chicken beta-globin domain serves as an insulator in human erythroid cells and protects against position effect in Drosophila

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The protein CTCF is required for the enhancer blocking activity of vertebrate insulators

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The insulation of genes from external enhancers and silencing chromatin

21 January 2018

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CTCF: master weaver of the genome

21 January 2018

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Chromatin boundaries, insulators, and long-range interactions in the nucleus

21 January 2018

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Analysis of the vertebrate insulator protein CTCF-binding sites in the human genome

21 January 2018

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Widespread plasticity in CTCF occupancy linked to DNA methylation

21 January 2018

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Waves of retrotransposon expansion remodel genome organization and CTCF binding in multiple mammalian lineages

21 January 2018

1 reference

Cohesins functionally associate with CTCF on mammalian chromosome arms

21 January 2018

1 reference

Topological domains in mammalian genomes identified by analysis of chromatin interactions

21 January 2018

1 reference

A chromatin insulator protects retrovirus vectors from chromosomal position effects

21 January 2018

1 reference

Improved human beta-globin expression from self-inactivating lentiviral vectors carrying the chicken hypersensitive site-4 (cHS4) insulator element

21 January 2018

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A chromatin insulator blocks interactions between globin regulatory elements and cellular promoters in erythroid cells

21 January 2018

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The chicken hypersensitivity site 4 core insulator blocks promoter interference in lentiviral vectors

21 January 2018

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Genomic and functional assays demonstrate reduced gammaretroviral vector genotoxicity associated with use of the cHS4 chromatin insulator

21 January 2018

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An experimental system for the evaluation of retroviral vector design to diminish the risk for proto-oncogene activation

21 January 2018

1 reference

Critical DNA binding interactions of the insulator protein CTCF: a small number of zinc fingers mediate strong binding, and a single finger-DNA interaction controls binding at imprinted loci

21 January 2018

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Cohesin mediates transcriptional insulation by CCCTC-binding factor

21 January 2018

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CTCF is a uniquely versatile transcription regulator linked to epigenetics and disease

21 January 2018

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A genome-wide map of CTCF multivalency redefines the CTCF code

21 January 2018

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Extensive promoter-centered chromatin interactions provide a topological basis for transcription regulation

21 January 2018

1 reference

Gene therapy for SCID-X1: focus on clinical data

21 January 2018

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Gene therapy fulfilling its promise

21 January 2018

1 reference

Genomic instability and myelodysplasia with monosomy 7 consequent to EVI1 activation after gene therapy for chronic granulomatous disease

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Gene therapy activates EVI1, destabilizes chromosomes.

21 January 2018

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Gene therapy for the Wiskott-Aldrich syndrome

21 January 2018

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Gammaretrovirus-mediated correction of SCID-X1 is associated with skewed vector integration site distribution in vivo

21 January 2018

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Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapy

21 January 2018

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Multilineage hematopoietic reconstitution without clonal selection in ADA-SCID patients treated with stem cell gene therapy

21 January 2018

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Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients

21 January 2018

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Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1

21 January 2018

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Gene Expression Commons: an open platform for absolute gene expression profiling

21 January 2018

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Open chromatin defined by DNaseI and FAIRE identifies regulatory elements that shape cell-type identity

21 January 2018

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Identification and characterization of cell type-specific and ubiquitous chromatin regulatory structures in the human genome

21 January 2018

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VEZF1 elements mediate protection from DNA methylation

21 January 2018

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Design and analysis of ChIP-seq experiments for DNA-binding proteins

21 January 2018

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BEDOPS: high-performance genomic feature operations

21 January 2018

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The accessible chromatin landscape of the human genome

21 January 2018

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Simultaneous sequence transfer into two independent locations of a reporter vector using MultiSite Gateway technology.

21 January 2018

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Extended core sequences from the cHS4 insulator are necessary for protecting retroviral vectors from silencing position effects

21 January 2018

1 reference

Suppression of clonal dominance in cultured human lymphoid cells by addition of the cHS4 insulator to a lentiviral vector

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25580597

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NBT.3062

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2 August 2017

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