(Q45869421)

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Improved human beta-globin expression from self-inactivating lentiviral vectors carrying the chicken hypersensitive site-4 (cHS4) insulator element

scientific article published on 10 July 2007

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/17622240

Improved human beta-globin expression from self-inactivating lentiviral vectors carrying the chicken hypersensitive site-4 (cHS4) insulator element (English)

1 reference

Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/17622240

author name string

Paritha I Arumugam

1

1 reference

Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/17622240

Jessica Scholes

2

1 reference

Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/17622240

Natalya Perelman

3

1 reference

Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/17622240

Ping Xia

4

1 reference

Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/17622240

Jiing-Kuan Yee

5

1 reference

Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/17622240

Punam Malik

6

1 reference

Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/17622240

publication date

10 July 2007

1 reference

Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/17622240

Molecular Therapy

1 reference

Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/17622240

15

1 reference

Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/17622240

10

1 reference

Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/17622240

1863-1871

1 reference

Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/17622240

Generation of a high-titer retroviral vector capable of expressing high levels of the human beta-globin gene

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Retroviral vectors aimed at the gene therapy of human beta-globin gene disorders

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High-level beta-globin expression after retroviral transfer of locus activation region-containing human beta-globin gene derivatives into murine erythroleukemia cells

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Mutagenesis of retroviral vectors transducing human beta-globin gene and beta-globin locus control region derivatives results in stable transmission of an active transcriptional structure

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Retroviral transfer of a human beta-globin/delta-globin hybrid gene linked to beta locus control region hypersensitive site 2 aimed at the gene therapy of sickle cell disease

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Therapeutic haemoglobin synthesis in beta-thalassaemic mice expressing lentivirus-encoded human beta-globin

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Permanent and panerythroid correction of murine beta thalassemia by multiple lentiviral integration in hematopoietic stem cells

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The degree of phenotypic correction of murine beta -thalassemia intermedia following lentiviral-mediated transfer of a human gamma-globin gene is influenced by chromosomal position effects and vector copy number

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Extended beta-globin locus control region elements promote consistent therapeutic expression of a gamma-globin lentiviral vector in murine beta-thalassemia

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HIV-1 integration in the human genome favors active genes and local hotspots

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Transcription start regions in the human genome are favored targets for MLV integration

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LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1

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Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1.

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High-level beta-globin expression and preferred intragenic integration after lentiviral transduction of human cord blood stem cells

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A novel murine model of Cooley anemia and its rescue by lentiviral-mediated human beta-globin gene transfer

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Gene expression in proliferating human erythroid cells

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Development of virus vectors for gene therapy of beta chain hemoglobinopathies: flanking with a chromatin insulator reduces gamma-globin gene silencing in vivo

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Topological constraints governing the use of the chicken HS4 chromatin insulator in oncoretrovirus vectors

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Performance- and safety-enhanced lentiviral vectors containing the human interferon-beta scaffold attachment region and the chicken beta-globin insulator

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The protein CTCF is required for the enhancer blocking activity of vertebrate insulators

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Characterization of the chicken beta-globin insulator

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Genomic organization of gypsy chromatin insulators in Drosophila melanogaster

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Activation of the beta globin locus by transcription factors and chromatin modifiers

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The insulation of genes from external enhancers and silencing chromatin

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The 5'-HS4 chicken beta-globin insulator is a CTCF-dependent nuclear matrix-associated element

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Successful correction of the human beta-thalassemia major phenotype using a lentiviral vector

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Hematopoietic stem cell gene therapy of murine protoporphyria by methylguanine-DNA-methyltransferase-mediated in vivo drug selection

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Functional requirements for phenotypic correction of murine beta-thalassemia: implications for human gene therapy

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The cHS4 insulator increases the probability of retroviral expression at random chromosomal integration sites.

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Position-effect protection and enhancer blocking by the chicken beta-globin insulator are separable activities

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Promoter trapping reveals significant differences in integration site selection between MLV and HIV vectors in primary hematopoietic cells

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Murine leukemia induced by retroviral gene marking

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Side effects of retroviral gene transfer into hematopoietic stem cells

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Lentiviral vector transduction of NOD/SCID repopulating cells results in multiple vector integrations per transduced cell: risk of insertional mutagenesis

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Recurrent retroviral vector integration at the Mds1/Evi1 locus in nonhuman primate hematopoietic cells

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Identifiers

10.1038/SJ.MT.6300259

1 reference

Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/17622240

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/17622240

ResearchGate publication ID

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