(Q34458478)

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Gastrin-releasing peptide/neuromedin B receptor antagonists PD176252, PD168368, and related analogs are potent agonists of human formyl-peptide receptors.

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scholarly article

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15 February 2020

Gastrin-releasing peptide/neuromedin B receptor antagonists PD176252, PD168368, and related analogs are potent agonists of human formyl-peptide receptors (English)

1 reference

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15 February 2020

Andrei I Khlebnikov

3

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15 February 2020

Igor A Schepetkin

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object named as

Igor A Schepetkin

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15 February 2020

author name string

Liliya N Kirpotina

2

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15 February 2020

Mark A Jutila

4

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15 February 2020

Mark T Quinn

5

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15 February 2020

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13 October 2010

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15 February 2020

Molecular Pharmacology

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15 February 2020

79

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15 February 2020

1

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15 February 2020

77-90

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15 February 2020

Therapeutic anti-inflammatory potential of formyl-peptide receptor agonists

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014281

6 July 2018

Human formyl peptide receptor 2 senses highly pathogenic Staphylococcus aureus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014281

6 July 2018

Are formyl peptide receptors novel targets for therapeutic intervention in ischaemia-reperfusion injury?

1 reference

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6 July 2018

Forced unbinding of GPR17 ligands from wild type and R255I mutant receptor models through a computational approach

1 reference

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6 July 2018

The annexin I sequence gln(9)-ala(10)-trp(11)-phe(12) is a core structure for interaction with the formyl peptide receptor 1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014281

6 July 2018

GPCR 3D homology models for ligand screening: lessons learned from blind predictions of adenosine A2a receptor complex

1 reference

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6 July 2018

Identification of novel small-molecule agonists for human formyl peptide receptors and pharmacophore models of their recognition.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014281

6 July 2018

6-methyl-2,4-disubstituted pyridazin-3(2H)-ones: a novel class of small-molecule agonists for formyl peptide receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014281

6 July 2018

International Union of Basic and Clinical Pharmacology. LXXIII. Nomenclature for the formyl peptide receptor (FPR) family

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014281

6 July 2018

Formyl peptide receptors are candidate chemosensory receptors in the vomeronasal organ

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014281

6 July 2018

Analysis of full and partial agonists binding to beta2-adrenergic receptor suggests a role of transmembrane helix V in agonist-specific conformational changes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014281

6 July 2018

Identification of novel formyl peptide receptor-like 1 agonists that induce macrophage tumor necrosis factor alpha production.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014281

6 July 2018

Molecule-pharmacophore superpositioning and pattern matching in computational drug design

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014281

6 July 2018

Discovery of Trp-Nle-Tyr-Met as a novel agonist for human formyl peptide receptor-like 1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014281

6 July 2018

Antitumor mechanisms of combined gastrin-releasing peptide receptor and epidermal growth factor receptor targeting in head and neck cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014281

6 July 2018

High-throughput screening for small-molecule activators of neutrophils: identification of novel N-formyl peptide receptor agonists

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014281

6 July 2018

Bombesin receptors as a novel anti-anxiety therapeutic target: BB1 receptor actions on anxiety through alterations of serotonin activity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014281

6 July 2018

Structure-activity relationship of for-L-Met L-Leu-L-Phe-OMe analogues in human neutrophils

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014281

6 July 2018

Bombesin/gastrin-releasing peptide receptor antagonists increase the ability of histone deacetylase inhibitors to reduce lung cancer proliferation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014281

6 July 2018

A novel nonpeptide ligand for formyl peptide receptor-like 1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014281

6 July 2018

Identification of peptides that antagonize formyl peptide receptor-like 1-mediated signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014281

6 July 2018

Measurement of NAD(P)H oxidase-derived superoxide with the luminol analogue L-012.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014281

6 July 2018

Differential activation of formyl peptide receptor-like 1 by peptide ligands

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014281

6 July 2018

Nonpeptide gastrin releasing peptide receptor antagonists inhibit the proliferation of lung cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014281

6 July 2018

The neuromedin B receptor antagonist, BIM-23127, is a potent antagonist at human and rat urotensin-II receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014281

6 July 2018

The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014281

6 July 2018

A G protein-coupled receptor responsive to bile acids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014281

6 July 2018

Phagocyte activation by Trp-Lys-Tyr-Met-Val-Met, acting through FPRL1/LXA4R, is not affected by lipoxin A4

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014281

6 July 2018

Characterization of chenodeoxycholic acid as an endogenous antagonist of the G-coupled formyl peptide receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014281

6 July 2018

Nonpeptide neuromedin B receptor antagonists inhibit the proliferation of C6 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014281

6 July 2018

Tyrosine 220 in the 5th transmembrane domain of the neuromedin B receptor is critical for the high selectivity of the peptoid antagonist PD168368.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014281

6 July 2018

Comparative pharmacology of the nonpeptide neuromedin B receptor antagonist PD 168368

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014281

6 July 2018

PD 176252--the first high affinity non-peptide gastrin-releasing peptide (BB2) receptor antagonist

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014281

6 July 2018

Cholecystokinin increases intracellular Ca2+ concentration in the Human JURKAT T Lymphocyte cell line

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014281

6 July 2018

The 'peptoid' approach to the design of non-peptide, small molecule agonists and antagonists of neuropeptides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014281

6 July 2018

Extended electron distributions applied to the molecular mechanics of some intermolecular interactions.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014281

6 July 2018

The HL60 cell line: a model system for studying human myeloid cell differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014281

6 July 2018

Cholecystokinin and the immune system: receptor-mediated chemotaxis of human and rat monocytes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014281

6 July 2018

N-formylmethionyl peptides as chemoattractants for leucocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014281

6 July 2018

Mitochondrial peptides are potent immune activators that activate human neutrophils via FPR-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014281

27 October 2018

The anionic amphiphile SDS is an antagonist for the human neutrophil formyl peptide receptor 1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014281

27 October 2018

Definition of the G protein-coupled receptor transmembrane bundle binding pocket and calculation of receptor similarities for drug design.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014281

27 October 2018

New 'chemical probes' to examine the role of the hFPRL1 (or ALXR) receptor in inflammation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014281

27 October 2018

Molecular field extrema as descriptors of biological activity: definition and validation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014281

27 October 2018

Integration of virtual screening with high-throughput flow cytometry to identify novel small molecule formylpeptide receptor antagonists

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014281

27 October 2018

Differential signaling of formyl peptide receptor-like 1 by Trp-Lys-Tyr-Met-Val-Met-CONH2 or lipoxin A4 in human neutrophils

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014281

27 October 2018

Molecular evolution of the N-formyl peptide and C5a receptors in non-human primates.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014281

27 October 2018

CCK-A receptor selective antagonists derived from the CCK-A receptor selective tetrapeptide agonist Boc-Trp-Lys(Tac)-Asp-MePhe-NH2 (A-71623).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014281

27 October 2018

Potent hFPRL1 (ALXR) agonists as potential anti-inflammatory agents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014281

27 October 2018

Induction of the respiratory burst in HL-60 cells. Correlation of function and protein expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3014281

27 October 2018

The peptide Trp-Lys-Tyr-Met-Val-D-Met activates neutrophils through the formyl peptide receptor only when signaling through the formylpeptide receptor like 1 is blocked. A receptor switch with implications for signal transduction studies with inhibi

1 reference

https://pubmed.ncbi.nlm.nih.gov/20943772

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular field technology applied to virtual screening and finding the bioactive conformation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20943772

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of human neutrophil functions by sulfated and nonsulfated cholecystokinin octapeptides

1 reference

https://pubmed.ncbi.nlm.nih.gov/20943772

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of the Binding Site on the Formyl Peptide Receptor Using Three Receptor Mutants and Analogs of Met-Leu-Phe and Met-Met-Trp-Leu-Leu

1 reference

https://pubmed.ncbi.nlm.nih.gov/20943772

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of inflammation by vasoactive intestinal peptide and bombesin: lack of effects on neutrophil apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20943772

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Signal transducing properties of the N-formyl peptide receptor expressed in undifferentiated HL60 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20943772

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PMN degranulation in relation to CD63 expression and genetic polymorphisms in healthy individuals and COPD patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/20943772

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1124/MOL.110.068288

1 reference

Europe PubMed Central

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15 February 2020

1 reference

Europe PubMed Central

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15 February 2020

1 reference

Europe PubMed Central

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15 February 2020

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