(Q34461976)

2 August 2017

title

Fatty acid-binding proteins (FABPs) are intracellular carriers for Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD). (English)

1 reference

2 August 2017

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Martin Kaczocha

2

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Iwao Ojima

object named as

Iwao Ojima

10

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author name string

Matthew W Elmes

1

1 reference

2 August 2017

William T Berger

3

1 reference

2 August 2017

KwanNok Leung

4

1 reference

2 August 2017

Brian P Ralph

5

1 reference

2 August 2017

Liqun Wang

6

1 reference

2 August 2017

Joseph M Sweeney

7

1 reference

2 August 2017

Jeremy T Miyauchi

8

1 reference

2 August 2017

Stella E Tsirka

9

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2 August 2017

Dale G Deutsch

11

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2 August 2017

language of work or name

English

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publication date

9 February 2015

1 reference

Journal of Biological Chemistry

2 August 2017

number of pages

11

1 reference

based on heuristic

inferred from page(s)

published in

1 reference

2 August 2017

volume

290

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2 August 2017

issue

14

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2 August 2017

page(s)

8711-8721

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Involvement of fatty acid amide hydrolase and fatty acid binding protein 5 in the uptake of anandamide by cell lines with different levels of fatty acid amide hydrolase expression: a pharmacological study

2 August 2017

cites work

1 reference

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6 July 2018

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Inhibition of fatty acid binding proteins elevates brain anandamide levels and produces analgesia.

6 July 2018

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Fatty acid-binding protein 5 (FABP5) regulates cognitive function both by decreasing anandamide levels and by activating the nuclear receptor peroxisome proliferator-activated receptor β/δ (PPARβ/δ) in the brain

6 July 2018

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Crystallographic study of FABP5 as an intracellular endocannabinoid transporter

6 July 2018

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Impact of enzymatic and alkaline hydrolysis on CBD concentration in urine

6 July 2018

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Analysis of cannabinoids in laser-microdissected trichomes of medicinal Cannabis sativa using LCMS and cryogenic NMR.

6 July 2018

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Targeting fatty acid binding protein (FABP) anandamide transporters - a novel strategy for development of anti-inflammatory and anti-nociceptive drugs

6 July 2018

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A double-blind, randomized, placebo-controlled, parallel-group study of THC/CBD oromucosal spray in combination with the existing treatment regimen, in the relief of central neuropathic pain in patients with multiple sclerosis.

6 July 2018

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Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia

6 July 2018

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6 July 2018

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Fatty acid-binding proteins transport N-acylethanolamines to nuclear receptors and are targets of endocannabinoid transport inhibitors

6 July 2018

1 reference

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Endocannabinoid tone versus constitutive activity of cannabinoid receptors

6 July 2018

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Implementation and evaluation of a docking-rescoring method using molecular footprint comparisons

6 July 2018

1 reference

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Discovery and molecular basis of potent noncovalent inhibitors of fatty acid amide hydrolase (FAAH)

6 July 2018

1 reference

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Effects of cannabinoids and cannabinoid-enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes

6 July 2018

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Docking validation resources: protein family and ligand flexibility experiments

6 July 2018

1 reference

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Antidepressant-like effects of cannabidiol in mice: possible involvement of 5-HT1A receptors

6 July 2018

1 reference

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Lipid droplets are novel sites of N-acylethanolamine inactivation by fatty acid amide hydrolase-2.

6 July 2018

1 reference

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Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb

6 July 2018

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Binding and Inactivation Mechanism of a Humanized Fatty Acid Amide Hydrolase by α-Ketoheterocycle Inhibitors Revealed from Cocrystal Structures

6 July 2018

1 reference

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Quantitative prediction of fold resistance for inhibitors of EGFR.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423662

Molecular identification of albumin and Hsp70 as cytosolic anandamide-binding proteins

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423662

Discovery and Characterization of a Highly Selective FAAH Inhibitor that Reduces Inflammatory Pain

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423662

Identification of intracellular carriers for the endocannabinoid anandamide

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423662

Structure-guided inhibitor design for human FAAH by interspecies active site conversion

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423662

Human microglial cells synthesize albumin in brain

6 July 2018

1 reference

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The endogenous fatty acid amide, palmitoylethanolamide, has anti-allodynic and anti-hyperalgesic effects in a murine model of neuropathic pain: involvement of CB(1), TRPV1 and PPARgamma receptors and neurotrophic factors

6 July 2018

1 reference

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Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets

6 July 2018

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Neuropharmacology of the endocannabinoid signaling system-molecular mechanisms, biological actions and synaptic plasticity.

6 July 2018

1 reference

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The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: delta9-tetrahydrocannabinol, cannabidiol and delta9-tetrahydrocannabivarin

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423662

Human cannabinoid pharmacokinetics

6 July 2018

1 reference

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Efficacy of dronabinol alone and in combination with ondansetron versus ondansetron alone for delayed chemotherapy-induced nausea and vomiting

6 July 2018

1 reference

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Randomized controlled trial of cannabis-based medicine in spasticity caused by multiple sclerosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423662

Repeated treatment with cannabidiol but not Delta9-tetrahydrocannabinol has a neuroprotective effect without the development of tolerance

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423662

Meta-analysis of cannabis based treatments for neuropathic and multiple sclerosis-related pain

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423662

Comparison of multiple Amber force fields and development of improved protein backbone parameters

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423662

Antitumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423662

Pharmacokinetics and metabolism of the plant cannabinoids, delta9-tetrahydrocannabinol, cannabidiol and cannabinol

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423662

Scalable molecular dynamics with NAMD

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423662

UCSF Chimera--a visualization system for exploratory research and analysis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423662

Exploring protein native states and large-scale conformational changes with a modified generalized born model

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423662

CB1 cannabinoid receptors and on-demand defense against excitotoxicity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423662

Structural adaptations in a membrane enzyme that terminates endocannabinoid signaling

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423662

International Union of Pharmacology. XXVII. Classification of cannabinoid receptors

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423662

Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423662

Role of fatty acid amide hydrolase in the transport of the endogenous cannabinoid anandamide

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423662

Calculating structures and free energies of complex molecules: combining molecular mechanics and continuum models

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423662

Crystal structure and thermodynamic analysis of human brain fatty acid-binding protein

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423662

Expression, purification, and crystal structure determination of recombinant human epidermal-type fatty acid binding protein

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423662

An entourage effect: inactive endogenous fatty acid glycerol esters enhance 2-arachidonoyl-glycerol cannabinoid activity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423662

Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423662

Enzymatic synthesis and degradation of anandamide, a cannabinoid receptor agonist

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423662

Evidence that cannabidiol does not significantly alter the pharmacokinetics of tetrahydrocannabinol in man

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4423662

The anxiolytic-like effects of cannabidiol injected into the bed nucleus of the stria terminalis are mediated by 5-HT1A receptors

6 July 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.618447

Binding of δ9-tetrahydrocannabinol and diazepam to human serum albumin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.618447

Pharmacokinetics and Metabolism of the Plant Cannabinoids, Δ9-Tetrahydrocannibinol, Cannabidiol and Cannabinol

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.618447

A water-based mechanism of specificity and resistance for lapatinib with ErbB family kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.618447

Comparison of simple potential functions for simulating liquid water

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.618447

Numerical integration of the cartesian equations of motion of a system with constraints: molecular dynamics of n-alkanes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.618447

Particle mesh Ewald: An N⋅log(N) method for Ewald sums in large systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.618447

The cellular uptake of anandamide is coupled to its breakdown by fatty-acid amide hydrolase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.618447

Endocannabinoids: endogenous cannabinoid receptor ligands with neuromodulatory action

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.618447

Enhancement of the hypotensive effects of intrathecally injected endocannabinoids by the entourage compound palmitoylethanolamide

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.618447

Exogenous delta⁹-tetrahydrocannabinol influences circulating endogenous cannabinoids in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.618447

Randomized, double-blind, placebo-controlled study about the effects of cannabidiol (CBD) on the pharmacokinetics of Delta9-tetrahydrocannabinol (THC) after oral application of THC verses standardized cannabis extract

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.618447

Effect of sublingual application of cannabinoids on intraocular pressure: a pilot study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.618447

3H-Δ9-tetrahydrocannabinol, 3H-cannabinol and 3H-cannabidiol: Penetration and regional distribution in rat brain

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25666611

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M114.618447

1 reference

2 August 2017

1 reference

2 August 2017

1 reference