(Q34469971)

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Functional proteomics of the epigenetic regulators ASXL1, ASXL2 and ASXL3: a convergence of proteomics and epigenetics for translational medicine

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scholarly article

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Europe PubMed Central

2 August 2017

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Europe PubMed Central

Functional proteomics of the epigenetic regulators ASXL1, ASXL2 and ASXL3: a convergence of proteomics and epigenetics for translational medicine (English)

1 reference

Europe PubMed Central

2 August 2017

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Masaru Katoh

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Europe PubMed Central

2 August 2017

language of work or name

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3 April 2015

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Europe PubMed Central

2 August 2017

Expert Review of Proteomics

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Europe PubMed Central

2 August 2017

12

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Europe PubMed Central

2 August 2017

3

1 reference

Europe PubMed Central

2 August 2017

317-328

1 reference

Europe PubMed Central

2 August 2017

Mass spectrometry-based proteomics turns quantitative

1 reference

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21 January 2018

Proteomics by mass spectrometry: approaches, advances, and applications

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21 January 2018

Great challenges in molecular medicine: toward personalized medicine

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21 January 2018

Mapping protein post-translational modifications with mass spectrometry

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21 January 2018

Large-scale mapping of human protein-protein interactions by mass spectrometry

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21 January 2018

Structural investigations of the nickel-induced inhibition of truncated constructs of the JMJD2 family of histone demethylases using X-ray absorption spectroscopy

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21 January 2018

Mode and specificity of binding of the small molecule GANT61 to GLI determines inhibition of GLI-DNA binding.

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21 January 2018

KDM4B as a target for prostate cancer: structural analysis and selective inhibition by a novel inhibitor

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21 January 2018

G protein-coupled receptors: novel targets for drug discovery in cancer

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21 January 2018

Hedgehog target genes: mechanisms of carcinogenesis induced by aberrant hedgehog signaling activation

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21 January 2018

Targeting hedgehog in hematologic malignancy.

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21 January 2018

FGF receptors: cancer biology and therapeutics

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21 January 2018

FGFR1 Kinase Inhibitors: Close Regioisomers Adopt Divergent Binding Modes and Display Distinct Biophysical Signatures

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21 January 2018

Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors

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21 January 2018

The inheritance of epigenetic defects

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21 January 2018

An operational definition of epigenetics

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21 January 2018

Cardio-miRNAs and onco-miRNAs: circulating miRNA-based diagnostics for non-cancerous and cancerous diseases

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21 January 2018

A decade of exploring the cancer epigenome - biological and translational implications

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21 January 2018

Cancer genomics identifies disrupted epigenetic genes

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21 January 2018

Epigenetics and cardiovascular disease

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21 January 2018

Integrating genetics and epigenetics in myelodysplastic syndromes: advances in pathogenesis and disease evolution

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21 January 2018

Epigenetic drugs against cancer: an evolving landscape

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21 January 2018

Selective Inhibitors of the JMJD2 Histone Demethylases: Combined Nondenaturing Mass Spectrometric Screening and Crystallographic Approaches

1 reference

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21 January 2018

Cancer epigenetics: from mechanism to therapy

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21 January 2018

Epigenetic modifications as potential therapeutic targets in age-related macular degeneration and diabetic retinopathy

1 reference

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21 January 2018

The deubiquitinating enzyme BAP1 regulates cell growth via interaction with HCF-1.

1 reference

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21 January 2018

Loss of the tumor suppressor BAP1 causes myeloid transformation

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21 January 2018

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions

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21 January 2018

A quantitative atlas of mitotic phosphorylation

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21 January 2018

Chromatin proteomics and epigenetic regulatory circuits.

1 reference

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21 January 2018

A human homolog of Additional sex combs, ADDITIONAL SEX COMBS-LIKE 1, maps to chromosome 20q11

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2015.1033409

21 January 2018

Mutations of polycomb-associated gene ASXL1 in myelodysplastic syndromes and chronic myelomonocytic leukaemia.

1 reference

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21 January 2018

De novo nonsense mutations in ASXL1 cause Bohring-Opitz syndrome

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2015.1033409

21 January 2018

De novo truncating mutations in ASXL3 are associated with a novel clinical phenotype with similarities to Bohring-Opitz syndrome

1 reference

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21 January 2018

Functional and cancer genomics of ASXL family members

1 reference

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21 January 2018

Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2015.1033409

21 January 2018

Additional sex comb-like 1 (ASXL1), in cooperation with SRC-1, acts as a ligand-dependent coactivator for retinoic acid receptor

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2015.1033409

21 January 2018

ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2015.1033409

21 January 2018

Additional sex combs-like 2 is required for polycomb repressive complex 2 binding at select targets

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2015.1033409

21 January 2018

WTIP interacts with ASXL2 and blocks ASXL2-mediated activation of retinoic acid signaling

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2015.1033409

21 January 2018

Delineation of a new chromosome 20q11.2 duplication syndrome including the ASXL1 gene

1 reference

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21 January 2018

Identification of copy number gain and overexpressed genes on chromosome arm 20q by an integrative genomic approach in cervical cancer: potential role in progression.

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21 January 2018

Synaptic, transcriptional and chromatin genes disrupted in autism

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21 January 2018

Autism spectrum disorders and autistic traits: a decade of new twin studies

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21 January 2018

Expanding our knowledge of conditions associated with the ASXL gene family

1 reference

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21 January 2018

Mutations in ASXL1 are associated with poor prognosis across the spectrum of malignant myeloid diseases

1 reference

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21 January 2018

Frequent ASXL2 mutations in acute myeloid leukemia patients with t(8;21)/RUNX1-RUNX1T1 chromosomal translocations.

1 reference

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21 January 2018

ASXL genes and RUNX1: an intimate connection?

1 reference

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21 January 2018

The landscape of cancer genes and mutational processes in breast cancer

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21 January 2018

The mutational landscape of lethal castration-resistant prostate cancer

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21 January 2018

Nonsense mediated decay resistant mutations are a source of expressed mutant proteins in colon cancer cell lines with microsatellite instability

1 reference

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21 January 2018

The landscape of somatic mutations in epigenetic regulators across 1,000 paediatric cancer genomes.

1 reference

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21 January 2018

The mutational landscape of head and neck squamous cell carcinoma

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21 January 2018

Inactivating mutations of the chromatin remodeling gene ARID2 in hepatocellular carcinoma

1 reference

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21 January 2018

Recurrent inactivation of STAG2 in bladder cancer is not associated with aneuploidy.

1 reference

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21 January 2018

Core signaling pathways in human pancreatic cancers revealed by global genomic analyses

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21 January 2018

Integrated analysis of germline and somatic variants in ovarian cancer.

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2015.1033409

21 January 2018

Myelodysplastic syndromes are induced by histone methylation–altering ASXL1 mutations

1 reference

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21 January 2018

Additional sex comb-like (ASXL) proteins 1 and 2 play opposite roles in adipogenesis via reciprocal regulation of peroxisome proliferator-activated receptor {gamma}

1 reference

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21 January 2018

Reciprocal regulation of LXRα activity by ASXL1 and ASXL2 in lipogenesis

1 reference

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21 January 2018

The nuclear receptor superfamily: a rosetta stone for physiology

1 reference

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21 January 2018

Nuclear receptors and chromatin: an inducible couple.

1 reference

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21 January 2018

Molecular genetics of prostate cancer: new prospects for old challenges

1 reference

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21 January 2018

Estrogen carcinogenesis in breast cancer

1 reference

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21 January 2018

The nuclear receptor superfamily and drug discovery

1 reference

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21 January 2018

Epigenetic regulation of estrogen signaling in breast cancer

1 reference

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21 January 2018

Genome regulation by polycomb and trithorax proteins

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2015.1033409

21 January 2018

Polycomb silencing mechanisms and the management of genomic programmes

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2015.1033409

21 January 2018

PHD fingers in human diseases: disorders arising from misinterpreting epigenetic marks

1 reference

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21 January 2018

Covalent histone modifications--miswritten, misinterpreted and mis-erased in human cancers

1 reference

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21 January 2018

Many keys to push: diversifying the 'readership' of plant homeodomain fingers

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21 January 2018

Solution structure of an atypical PHD finger in BRPF2 and its interaction with DNA

1 reference

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21 January 2018

Structural and functional insights into the human Börjeson-Forssman-Lehmann syndrome-associated protein PHF6.

1 reference

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21 January 2018

Dido3 PHD Modulates Cell Differentiation and Division

1 reference

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21 January 2018

DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA

1 reference

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21 January 2018

After a decade of study-ING, a PHD for a versatile family of proteins

1 reference

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21 January 2018

Functional characterization of human Polycomb-like 3 isoforms identifies them as components of distinct EZH2 protein complexes.

1 reference

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21 January 2018

Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger

1 reference

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21 January 2018

Selective anchoring of TFIID to nucleosomes by trimethylation of histone H3 lysine 4

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2015.1033409

21 January 2018

Biochemistry and biology of mammalian DNA methyltransferases

1 reference

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21 January 2018

MOZ and MORF, two large MYSTic HATs in normal and cancer stem cells

1 reference

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21 January 2018

Diverse functions of PHD fingers of the MLL/KMT2 subfamily

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2015.1033409

21 January 2018

Solution NMR structure and histone binding of the PHD domain of human MLL5.

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2015.1033409

21 January 2018

NSD3, a new SET domain-containing gene, maps to 8p12 and is amplified in human breast cancer cell lines

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2015.1033409

21 January 2018

KDM4/JMJD2 histone demethylases: epigenetic regulators in cancer cells

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2015.1033409

21 January 2018

Substrate- and cofactor-independent inhibition of histone demethylase KDM4C.

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2015.1033409

21 January 2018

JmjC-domain-containing proteins and histone demethylation

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2015.1033409

21 January 2018

Dynamic Regulation of Histone Lysine Methylation by Demethylases

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2015.1033409

21 January 2018

The histone-H3K4-specific demethylase KDM5B binds to its substrate and product through distinct PHD fingers

1 reference

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21 January 2018

The roles of Jumonji-type oxygenases in human disease

1 reference

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21 January 2018

Recognition of histone H3K4 trimethylation by the plant homeodomain of PHF2 modulates histone demethylation

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2015.1033409

21 January 2018

PHF8 activates transcription of rRNA genes through H3K4me3 binding and H3K9me1/2 demethylation

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2015.1033409

21 January 2018

Methylation of lysine 4 on histone H3: intricacy of writing and reading a single epigenetic mark

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2015.1033409

21 January 2018

The HARE-HTH and associated domains: novel modules in the coordination of epigenetic DNA and protein modifications

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2015.1033409

21 January 2018

Functional proteomics in histone research and epigenetics.

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2015.1033409

21 January 2018

The role of mutations in epigenetic regulators in myeloid malignancies

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2015.1033409

21 January 2018

The genetic basis of myelodysplasia and its clinical relevance

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2015.1033409

21 January 2018

Landscape of genetic lesions in 944 patients with myelodysplastic syndromes

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2015.1033409

21 January 2018

Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2015.1033409

21 January 2018

Multifaceted role of EZH2 in breast and prostate tumorigenesis: epigenetics and beyond

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2015.1033409

21 January 2018

FOXA1 antagonizes EZH2-mediated CDKN2A repression in carcinogenesis

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2015.1033409

21 January 2018

EZH2: biology, disease, and structure-based drug discovery

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2015.1033409

21 January 2018

Selective inhibition of BET bromodomains

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2015.1033409

21 January 2018

Chromodomain antagonists that target the polycomb-group methyllysine reader protein chromobox homolog 7 (CBX7)

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2015.1033409

21 January 2018

Identification and characterization of small molecule inhibitors of a plant homeodomain finger

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2015.1033409

21 January 2018

NUP98-PHF23 is a chromatin-modifying oncoprotein that causes a wide array of leukemias sensitive to inhibition of PHD histone reader function.

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2015.1033409

21 January 2018

ASXL1 mutations identify a high-risk subgroup of older patients with primary cytogenetically normal AML within the ELN Favorable genetic category

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2015.1033409

21 January 2018

Functional conservation of Asxl2, a murine homolog for the Drosophila enhancer of trithorax and polycomb group gene Asx

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2015.1033409

21 January 2018

Additional sex combs-like family genes are required for normal cardiovascular development

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2015.1033409

21 January 2018

Fusion of the additional sex combs like 1 and teashirt zinc finger homeobox 2 genes resulting from ider(20q) aberration in a patient with myelodysplastic syndrome.

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2015.1033409

21 January 2018

Alteration of enhancer of polycomb 1 at 10p11.2 is one of the genetic events leading to development of adult T-cell leukemia/lymphoma

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2015.1033409

21 January 2018

The leucine twenty homeobox (LEUTX) gene, which lacks a histone acetyltransferase domain, is fused to KAT6A in therapy-related acute myeloid leukemia with t(8;19)(p11;q13).

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2015.1033409

21 January 2018

Emerging Anatomy of the BAP1 Tumor Suppressor System

1 reference

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21 January 2018

Identifiers

10.1586/14789450.2015.1033409

1 reference

Europe PubMed Central

2 August 2017

1 reference

Europe PubMed Central

2 August 2017

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