(Q34479316)

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Islet-specific CTL cloned from a type 1 diabetes patient cause beta-cell destruction after engraftment into HLA-A2 transgenic NOD/scid/IL2RG null mice

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scholarly article

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Europe PubMed Central

PubMed publication ID

2 August 2017

Islet-specific CTL cloned from a type 1 diabetes patient cause beta-cell destruction after engraftment into HLA-A2 transgenic NOD/scid/IL2RG null mice (English)

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

type-1 diabetes

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1 reference

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inferred from title

Marieke Griffioen

object named as

Marieke Griffioen

10

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Sandra Laban

4

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Arno R van der Slik

object named as

Arno R van der Slik

5

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author name string

Wendy W J Unger

1

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Europe PubMed Central

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2 August 2017

Todd Pearson

2

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2 August 2017

Joana R F Abreu

3

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Europe PubMed Central

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2 August 2017

Sacha Mulder-van der Kracht

6

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Europe PubMed Central

PubMed publication ID

2 August 2017

Michel G D Kester

7

1 reference

Europe PubMed Central

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2 August 2017

Dave V Serreze

8

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Europe PubMed Central

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2 August 2017

Leonard D Shultz

9

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Europe PubMed Central

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2 August 2017

Jan Wouter Drijfhout

11

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Europe PubMed Central

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2 August 2017

Dale L Greiner

12

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2 August 2017

Bart O Roep

13

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2 August 2017

language of work or name

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publication date

14 November 2012

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Europe PubMed Central

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2 August 2017

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Europe PubMed Central

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2 August 2017

7

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Europe PubMed Central

PubMed publication ID

2 August 2017

11

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

e49213

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

copyright license

Creative Commons Attribution 4.0 International

14 November 2012

1 reference

April 2022 Public Data File from Crossref

copyright status

0 references

Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3498321

6 July 2018

HLA-A2-matched peripheral blood mononuclear cells from type 1 diabetic patients, but not nondiabetic donors, transfer insulitis to NOD-scid/γc(null)/HLA-A2 transgenic mice concurrent with the expansion of islet-specific CD8+ T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3498321

6 July 2018

Prevention of "Humanized" diabetogenic CD8 T-cell responses in HLA-transgenic NOD mice by a multipeptide coupled-cell approach

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3498321

6 July 2018

CD8(+) T lymphocyte mobilization to virus-infected tissue requires CD4(+) T-cell help

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3498321

6 July 2018

T cell islet accumulation in type 1 diabetes is a tightly regulated, cell-autonomous event

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3498321

6 July 2018

Dengue virus infection and virus-specific HLA-A2 restricted immune responses in humanized NOD-scid IL2rgammanull mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3498321

6 July 2018

Priming of protective T cell responses against virus-induced tumors in mice with human immune system components

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3498321

6 July 2018

CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3498321

6 July 2018

Weak proinsulin peptide-major histocompatibility complexes are targeted in autoimmune diabetes in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3498321

6 July 2018

Identification of novel IGRP epitopes targeted in type 1 diabetes patients.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3498321

6 July 2018

Restoring the association of the T cell receptor with CD8 reverses anergy in human tumor-infiltrating lymphocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3498321

6 July 2018

T-cell quality in memory and protection: implications for vaccine design

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3498321

6 July 2018

A new Hu-PBL model for the study of human islet alloreactivity based on NOD-scid mice bearing a targeted mutation in the IL-2 receptor gamma chain gene.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3498321

6 July 2018

Screening for insulitis in adult autoantibody-positive organ donors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3498321

6 July 2018

Human clonal CD8 autoreactivity to an IGRP islet epitope shared between mice and men.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3498321

6 July 2018

Humanized mice in translational biomedical research

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3498321

6 July 2018

Responses against islet antigens in NOD mice are prevented by tolerance to proinsulin but not IGRP.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3498321

6 July 2018

Autoreactive CD8 T cells associated with beta cell destruction in type 1 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3498321

6 July 2018

Development of functional human blood and immune systems in NOD/SCID/IL2 receptor {gamma} chain(null) mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3498321

6 July 2018

Prevention of diabetes by manipulation of anti-IGRP autoimmunity: high efficiency of a low-affinity peptide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3498321

6 July 2018

Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3498321

6 July 2018

Opinion: Satisfaction (not) guaranteed: re-evaluating the use of animal models of type 1 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3498321

6 July 2018

Identification of the beta cell antigen targeted by a prevalent population of pathogenic CD8+ T cells in autoimmune diabetes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3498321

6 July 2018

Beta cell MHC class I is a late requirement for diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3498321

6 July 2018

NOD/SCID/gamma(c)(null) mouse: an excellent recipient mouse model for engraftment of human cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3498321

6 July 2018

Functional evidence for the mediation of diabetogenic T cell responses by HLA-A2.1 MHC class I molecules through transgenic expression in NOD mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3498321

6 July 2018

Cross-reactive mycobacterial and self hsp60 epitope recognition in I-A(g7) expressing NOD, NOD-asp and Biozzi AB/H mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3498321

6 July 2018

The NOD mouse model of type 1 diabetes: as good as it gets?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3498321

6 July 2018

Phenotypic analysis of antigen-specific T lymphocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3498321

6 July 2018

CD8 T cell clones from young nonobese diabetic (NOD) islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4 cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3498321

6 July 2018

Human T-cell-mediated destruction of allogeneic dermal microvessels in a severe combined immunodeficient mouse

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3498321

6 July 2018

Multiple defects in innate and adaptive immunologic function in NOD/LtSz-scid mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3498321

6 July 2018

Beta-cell-cytotoxic CD8+ T cells from nonobese diabetic mice use highly homologous T cell receptor alpha-chain CDR3 sequences.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3498321

6 July 2018

A binding site for the T-cell co-receptor CD8 on the alpha 3 domain of HLA-A2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3498321

6 July 2018

Islet inflammation and CXCL10 in recent-onset type 1 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3498321

27 October 2018

Accumulation of autoreactive effector T cells and allo-specific regulatory T cells in the pancreas allograft of a type 1 diabetic recipient.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3498321

27 October 2018

Homing of human autoreactive T cells into pancreatic tissue of NOD-scid mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3498321

27 October 2018

Cross-priming of diabetogenic T cells dissociated from CTL-induced shedding of beta cell autoantigens.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3498321

27 October 2018

Different T Cell Receptor Affinity Thresholds and CD8 Coreceptor Dependence Govern Cytotoxic T Lymphocyte Activation and Tetramer Binding Properties

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3498321

9 December 2018

Alpha 3 domain mutants of peptide/MHC class I multimers allow the selective isolation of high avidity tumor-reactive CD8 T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/23155466

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/23155466

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

L3T4 and Lyt-2 T cells are both involved in the generation of low-dose streptozotocin-induced diabetes in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/23155466

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta 2-microglobulin-deficient NOD mice do not develop insulitis or diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/23155466

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Major histocompatibility complex class I-deficient NOD-B2mnull mice are diabetes and insulitis resistant

1 reference

https://pubmed.ncbi.nlm.nih.gov/23155466

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a CD8 T cell that can independently mediate autoimmune diabetes development in the complete absence of CD4 T cell helper functions

1 reference

https://pubmed.ncbi.nlm.nih.gov/23155466

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The pathogenesis of insulin-dependent diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/23155466

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A gene in the HLA class I region contributes to susceptibility to IDDM in the Finnish population. Childhood Diabetes in Finland (DiMe) Study Group

1 reference

https://pubmed.ncbi.nlm.nih.gov/23155466

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Islet-specific expression of CXCL10 causes spontaneous islet infiltration and accelerates diabetes development

1 reference

https://pubmed.ncbi.nlm.nih.gov/23155466

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HLA-A*0201-restricted T cells from humanized NOD mice recognize autoantigens of potential clinical relevance to type 1 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/23155466

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD8+ T-cell responses identify beta-cell autoimmunity in human type 1 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/23155466

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo cytotoxicity of insulin-specific CD8+ T-cells in HLA-A*0201 transgenic NOD mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/23155466

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dynamic programming of CD8+ T lymphocyte responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/23155466

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0049213

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

2012PLoSO...749213U

0 references

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24 November 2022

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PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

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