(Q29393228)

14 April 2017

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3

Matthias von Herrath

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14 April 2017

author name string

Bart O. Roep

series ordinal

1

1 reference

14 April 2017

Mark Atkinson

series ordinal

2

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14 April 2017

publication date

December 2004

1 reference

Nature Reviews Immunology

14 April 2017

published in

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14 April 2017

volume

4

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14 April 2017

page(s)

989-997

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14 April 2017

issue

12

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Projection of an immunological self shadow within the thymus by the aire protein

14 April 2017

cites work

1 reference

https://api.crossref.org/works/10.1038/NRI1502

Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/NRI1502

The NOD mouse model of type 1 diabetes: as good as it gets?

21 April 2017

1 reference

Insulin-dependent diabetes mellitus as an autoimmune disease

21 January 2018

1 reference

T cell-mediated inhibition of the transfer of autoimmune diabetes in NOD mice

21 January 2018

1 reference

Autoimmune syndromes in major histocompatibility complex (MHC) congenic strains of nonobese diabetic (NOD) mice. The NOD MHC is dominant for insulitis and cyclophosphamide-induced diabetes.

21 January 2018

1 reference

Immune cells, pancreas development, regeneration and type 1 diabetes

21 January 2018

1 reference

Animal models have little to teach us about type 1 diabetes: 1. In support of this proposal

21 January 2018

1 reference

NOD mouse colonies around the world--recent facts and figures

21 January 2018

1 reference

Relation between occurrence of type 1 diabetes and asthma

21 January 2018

1 reference

Allergy, parasites, and the hygiene hypothesis

21 January 2018

1 reference

Ablation of "tolerance" and induction of diabetes by virus infection in viral antigen transgenic mice

21 January 2018

1 reference

Pathological changes in the islet milieu precede infiltration of islets and destruction of beta-cells by autoreactive lymphocytes in a transgenic model of virus-induced IDDM.

21 January 2018

1 reference

Of mice and not men: differences between mouse and human immunology

21 January 2018

1 reference

Suppressor of cytokine signaling-1 overexpression protects pancreatic beta cells from CD8+ T cell-mediated autoimmune destruction.

21 January 2018

1 reference

T-cell receptor-transgenic NOD mice: a reductionist approach to understand autoimmune diabetes

21 January 2018

1 reference

Understanding autoimmune diabetes: insights from mouse models.

21 January 2018

1 reference

TNF‐α impairs peripheral tolerance towards β‐cells, and local costimulation by B7.1 enhances the effector function of diabetogenic T cells

21 January 2018

1 reference

Contribution of Fas to diabetes development

21 January 2018

1 reference

The nonobese diabetic mouse as a model of autoimmune diabetes: immune dysregulation gets the NOD.

21 January 2018

1 reference

The TCR-HA, INS-HA transgenic model of autoimmune diabetes: limitations and expectations

21 January 2018

1 reference

B lymphocytes are essential for the initiation of T cell-mediated autoimmune diabetes: analysis of a new "speed congenic" stock of NOD.Ig mu null mice

21 January 2018

1 reference

Effective destruction of Fas-deficient insulin-producing beta cells in type 1 diabetes

21 January 2018

1 reference

Depleting anti-CD4 monoclonal antibody cures new-onset diabetes, prevents recurrent autoimmune diabetes, and delays allograft rejection in nonobese diabetic mice.

21 January 2018

1 reference

Beta-cell function in new-onset type 1 diabetes and immunomodulation with a heat-shock protein peptide (DiaPep277): a randomised, double-blind, phase II trial

21 January 2018

1 reference

Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus

21 January 2018

1 reference

Chronic tumor necrosis factor alters T cell responses by attenuating T cell receptor signaling

21 January 2018

1 reference

CD4+ T cell help impairs CD8+ T cell deletion induced by cross-presentation of self-antigens and favors autoimmunity

21 January 2018

1 reference

Normal incidence of diabetes in NOD mice tolerant to glutamic acid decarboxylase

21 January 2018

1 reference

Introducing baselines for therapeutic use of regulatory T cells and cytokines in autoimmunity.

21 January 2018

1 reference

IL-10 is necessary and sufficient for autoimmune diabetes in conjunction with NOD MHC homozygosity

21 January 2018

1 reference

Prevalent CD8(+) T cell response against one peptide/MHC complex in autoimmune diabetes

21 January 2018

1 reference

Diabetes and tolerance in transgenic mice expressing class II MHC molecules in pancreatic beta cells

21 January 2018

1 reference

Autoimmune diabetes as a consequence of locally produced interleukin-2

21 January 2018

1 reference

Autoreactive CD4+ T cells protect from autoimmune diabetes via bystander suppression using the IL-4/Stat6 pathway.

21 January 2018

1 reference

Evidence for a primary islet autoantigen (preproinsulin 1) for insulitis and diabetes in the nonobese diabetic mouse

21 January 2018

1 reference

CD40L blockade prevents autoimmune diabetes by induction of bitypic NK/DC regulatory cells

21 January 2018

1 reference

How virus induces a rapid or slow onset insulin-dependent diabetes mellitus in a transgenic model

21 January 2018

1 reference

Effect of tumor necrosis factor alpha on insulin-dependent diabetes mellitus in NOD mice. I. The early development of autoimmunity and the diabetogenic process

21 January 2018

1 reference

Loss of pancreatic islet tolerance induced by beta-cell expression of interferon-gamma

21 January 2018

1 reference

Constitutive beta cell expression of IL-12 does not perturb self-tolerance but intensifies established autoimmune diabetes

21 January 2018

1 reference

Mechanism underlying counterregulation of autoimmune diabetes by IL-4.

21 January 2018

1 reference

The activity of immunoregulatory T cells mediating active tolerance is potentiated in nonobese diabetic mice by an IL-4-based retroviral gene therapy

21 January 2018

1 reference

Tolerance, not immunity, crucially depends on IL-2.

21 January 2018

1 reference

European Nicotinamide Diabetes Intervention Trial (ENDIT): a randomised controlled trial of intervention before the onset of type 1 diabetes

21 January 2018

1 reference

Infliximab (chimeric anti-tumour necrosis factor alpha monoclonal antibody) versus placebo in rheumatoid arthritis patients receiving concomitant methotrexate: a randomised phase III trial. ATTRACT Study Group

21 January 2018

1 reference

Medicine. The NIH Roadmap

21 January 2018

1 reference

T cell response in experimental autoimmune encephalomyelitis (EAE): role of self and cross-reactive antigens in shaping, tuning, and regulating the autopathogenic T cell repertoire

21 January 2018

1 reference

Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice.

21 January 2018

1 reference

Role of viruses in type I diabetes.

21 January 2018

1 reference

Dendritic cells induce autoimmune diabetes and maintain disease via de novo formation of local lymphoid tissue

21 January 2018

1 reference

Ontogeny of T cell tolerance to peripherally expressed antigens

21 January 2018

1 reference

Inhibition of autoimmune diabetes in nonobese diabetic mice by transgenic restoration of H2-E MHC class II expression: additive, but unequal, involvement of multiple APC subtypes

21 January 2018

1 reference

Coexpression of B7-1 and viral ("self") transgenes in pancreatic beta cells can break peripheral ignorance and lead to spontaneous autoimmune diabetes

21 January 2018

1 reference

Cytokine overproduction in healthy first degree relatives of patients with IDDM

21 January 2018

1 reference

The pathogenesis of insulin-dependent diabetes mellitus

21 January 2018

1 reference

Acceleration of diabetes in young NOD mice with a CD4+ islet-specific T cell clone

31 March 2020

1 reference

Insulin-specific T cells are a predominant component of islet infiltrates in pre-diabetic NOD mice

31 March 2020

1 reference

T-cell responses to autoantigens in IDDM. The search for the Holy Grail

31 March 2020

1 reference

The role of T-cells in the pathogenesis of Type 1 diabetes: from cause to cure

31 March 2020

1 reference

International Workshop on Lessons From Animal Models for Human Type 1 Diabetes: identification of insulin but not glutamic acid decarboxylase or IA-2 as specific autoantigens of humoral autoimmunity in nonobese diabetic mice.

31 March 2020

1 reference

Proposed guidelines on screening for risk of type 1 diabetes

31 March 2020

1 reference

Elimination of maternally transmitted autoantibodies prevents diabetes in nonobese diabetic mice

31 March 2020

1 reference

Juvenile autoimmune diabetes: a pathogenic role for maternal antibodies?

31 March 2020

1 reference

Transmission of maternal islet antibodies and risk of autoimmune diabetes in offspring of mothers with type 1 diabetes

31 March 2020

1 reference

Children with type-1 diabetes and their unaffected siblings have fewer symptoms of asthma

31 March 2020

1 reference

31 March 2020

Viruses and diabetes.

1 reference

Molecular mimicry and autoimmune disease

31 March 2020

1 reference

Different modes of pathogenesis in T-cell-dependent autoimmunity: clues from two TCR transgenic systems

31 March 2020

1 reference

A dual role for TNF-alpha in type 1 diabetes: islet-specific expression abrogates the ongoing autoimmune process when induced late but not early during pathogenesis

31 March 2020

1 reference

T helper cell subsets in insulin-dependent diabetes

31 March 2020

1 reference

Following a diabetogenic T cell from genesis through pathogenesis

31 March 2020

1 reference

Insulin-dependent diabetes mellitus

31 March 2020

1 reference

Genes and cellular requirements for autoimmune diabetes susceptibility in nonobese diabetic mice

31 March 2020

1 reference

Anti-CD3 antibody induces long-term remission of overt autoimmunity in nonobese diabetic mice

31 March 2020

1 reference

Vaccination against autoimmune mouse diabetes with a T-cell epitope of the human 65-kDa heat shock protein.

31 March 2020

1 reference

Reversal of established autoimmune diabetes by restoration of endogenous beta cell function

31 March 2020

1 reference

Cure of overt diabetes in NOD mice by transient treatment with anti-lymphocyte serum and exendin-4.

31 March 2020

1 reference

T-cell tolerance toward a transgenic beta-cell antigen and transcription of endogenous pancreatic genes in thymus

31 March 2020

1 reference

Control of autoimmune diabetes in NOD mice by GAD expression or suppression in beta cells

31 March 2020

1 reference

The temporal importance of TNFalpha expression in the development of diabetes

31 March 2020

1 reference

Acceleration of type 1 diabetes mellitus in proinsulin 2-deficient NOD mice

31 March 2020

1 reference

IFN-gamma action on pancreatic beta cells causes class I MHC upregulation but not diabetes

31 March 2020

1 reference

Virus-induced autoimmune diabetes: most beta-cells die through inflammatory cytokines and not perforin from autoreactive (anti-viral) cytotoxic T-lymphocytes.

31 March 2020

1 reference

CD28/B7 regulation of Th1 and Th2 subsets in the development of autoimmune diabetes

31 March 2020

1 reference

Transgenes and knockout mutations in animal models of type 1 diabetes and multiple sclerosis

31 March 2020

1 reference

Prevention of diabetes in nonobese diabetic mice by tumor necrosis factor (TNF): similarities between TNF-alpha and interleukin 1.

31 March 2020

1 reference

Genetic absence of gamma-interferon delays but does not prevent diabetes in NOD mice

31 March 2020

1 reference

Multiple defects of immune cell function in mice with disrupted interferon-gamma genes

31 March 2020

1 reference

Suppression and acceleration of autoimmune diabetes by neutralization of endogenous interleukin-12 in NOD mice.

31 March 2020

1 reference

Insulin-dependent diabetes in the NOD mouse model. II. Beta cell destruction in autoimmune diabetes is a TH2 and not a TH1 mediated event

31 March 2020

1 reference

Focal expression of interleukin-2 does not break unresponsiveness to "self" (viral) antigen expressed in beta cells but enhances development of autoimmune disease (diabetes) after initiation of an anti-self immune response

31 March 2020

1 reference

Protection from type 1 diabetes in the face of high levels of activated autoaggressive lymphocytes in a viral transgenic mouse model crossed to the SV129 strain

31 March 2020

1 reference

Effects of insulin in relatives of patients with type 1 diabetes mellitus

31 March 2020

1 reference

Spontaneous Diabetes Mellitus: Reversal and Prevention in the BB/W Rat with Antiserum to Rat Lymphocytes

31 March 2020

1 reference

Auto- and alloimmune reactivity to human islet allografts transplanted into type 1 diabetic patients.

31 March 2020

1 reference

Differential expression of glutamic acid decarboxylase in rat and human islets

31 March 2020

1 reference

Treatment of autoimmune diabetes and insulitis in NOD mice with heat shock protein 60 peptide p277

31 March 2020

1 reference

Reduction of diabetes incidence of BB Wistar rats by early prophylactic insulin treatment of diabetes-prone animals

31 March 2020

1 reference

Insulitis and diabetes in NOD mice reduced by prophylactic insulin therapy

31 March 2020

1 reference

Development of type 1 diabetes despite severe hereditary B-cell deficiency

31 March 2020

1 reference

Split tolerance of Th1 and Th2 cells in tolerance to Theiler's murine encephalomyelitis virus

31 March 2020

1 reference

The pathogenesis of autoimmunity in New Zealand mice

31 March 2020

1 reference

Breeding of a non-obese, diabetic strain of mice

31 March 2020

1 reference

Spontaneous diabetes mellitus syndrome in the rat. IV. Immunogenetic interactions of MHC and non-MHC components of the syndrome

31 March 2020

1 reference

A role for non-MHC genetic polymorphism in susceptibility to spontaneous autoimmunity

31 March 2020

1 reference

Recessive tolerance to preproinsulin 2 reduces but does not abolish type 1 diabetes

31 March 2020

1 reference

Beta cell expression of endogenous xenotropic retrovirus distinguishes diabetes-susceptible NOD/Lt from resistant NON/Lt mice

31 March 2020

1 reference

Major species differences between humans and rodents in the susceptibility to pancreatic beta-cell injury

31 March 2020

1 reference

Mice expressing both B7-1 and viral glycoprotein on pancreatic beta cells along with glycoprotein-specific transgenic T cells develop diabetes due to a breakdown of T-lymphocyte unresponsiveness

31 March 2020

1 reference

Virally induced inflammation triggers fratricide of Fas-ligand-expressing beta-cells

31 March 2020

1 reference

Interleukin-4 deficiency does not exacerbate disease in NOD mice.

31 March 2020

1 reference

Interleukin-4 but not interleukin-10 protects against spontaneous and recurrent type 1 diabetes by activated CD1d-restricted invariant natural killer T-cells.

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRI1502

1 reference