(Q34492012)

2 August 2017

The spliceosome is a therapeutic vulnerability in MYC-driven cancer (English)

1 reference

2 August 2017

0 references

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26331541%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Rocío Domínguez-Vidaña

12

1 reference

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1 June 2020

Jessica K Hartman

13

1 reference

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1 June 2020

Antrix Jain

18

1 reference

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1 June 2020

Joel R Neilson

23

1 reference

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1 June 2020

Xiang H-F Zhang

24

1 reference

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1 June 2020

author name string

Tiffany Y-T Hsu

1

1 reference

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1 June 2020

Nicholas J Neill

3

1 reference

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1 June 2020

Richard Marcotte

4

1 reference

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1 June 2020

Azin Sayad

5

1 reference

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1 June 2020

Christopher S Bland

6

1 reference

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1 June 2020

Gloria V Echeverria

7

1 reference

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1 June 2020

Tingting Sun

8

1 reference

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1 June 2020

Sarah J Kurley

9

1 reference

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1 June 2020

Siddhartha Tyagi

10

1 reference

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1 June 2020

Kristen L Karlin

11

1 reference

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1 June 2020

Alexander Renwick

14

1 reference

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1 June 2020

Kathleen Scorsone

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26331541%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Ronald J Bernardi

16

1 reference

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1 June 2020

Samuel O Skinner

17

1 reference

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1 June 2020

Mayra Orellana

19

1 reference

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1 June 2020

Chandraiah Lagisetti

20

1 reference

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1 June 2020

Ido Golding

21

1 reference

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1 June 2020

Sung Y Jung

22

1 reference

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1 June 2020

Thomas A Cooper

25

1 reference

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1 June 2020

Thomas R Webb

26

1 reference

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1 June 2020

Benjamin G Neel

27

1 reference

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1 June 2020

Chad A Shaw

28

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26331541%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Thomas F Westbrook

29

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26331541%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

language of work or name

English

0 references

publication date

2 September 2015

1 reference

2 August 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26331541%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

volume

525

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26331541%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

issue

7569

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26331541%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

page(s)

384-388

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26331541%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/nature14985

1 June 2020

exact match

0 references

cites work

MYC regulates the core pre-mRNA splicing machinery as an essential step in lymphomagenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4831063

Selective transcriptional regulation by Myc in cellular growth control and lymphomagenesis.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4831063

Activation and repression by oncogenic MYC shape tumour-specific gene expression profiles.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4831063

Protein and nucleotide biosynthesis are coupled by a single rate-limiting enzyme, PRPS2, to drive cancer

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4831063

An integrative analysis of colon cancer identifies an essential function for PRPF6 in tumor growth

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4831063

Genome recognition by MYC.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4831063

Optimization of antitumor modulators of pre-mRNA splicing.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4831063

Muscleblind-like 1 activates insulin receptor exon 11 inclusion by enhancing U2AF65 binding and splicing of the upstream intron

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4831063

MYC, metabolism, cell growth, and tumorigenesis.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4831063

Genome-wide RNAi screens in human brain tumor isolates reveal a novel viability requirement for PHF5A

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4831063

ATARiS: computational quantification of gene suppression phenotypes from multisample RNAi screens

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4831063

The spliceosome as a target of novel antitumour drugs

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4831063

c-Myc is a universal amplifier of expressed genes in lymphocytes and embryonic stem cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4831063

Transcriptional amplification in tumor cells with elevated c-Myc.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4831063

Essential gene profiles in breast, pancreatic, and ovarian cancer cells.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4831063

Targeting synthetic lethal interactions between Myc and the eIF4F complex impedes tumorigenesis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4831063

Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4831063

A SUMOylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4831063

Somatic SF3B1 mutation in myelodysplasia with ring sideroblasts

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4831063

The pINDUCER lentiviral toolkit for inducible RNA interference in vitro and in vivo

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4831063

c-Myc regulates transcriptional pause release

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4831063

Streamlined analysis schema for high-throughput identification of endogenous protein complexes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4831063

Management of breast cancer with targeted agents: importance of heterogeneity. [corrected].

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4831063

HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4831063

The role of Myc-induced protein synthesis in cancer

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4831063

Principles of cancer therapy: oncogene and non-oncogene addiction

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4831063

The spliceosome: design principles of a dynamic RNP machine

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4831063

Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4831063

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4831063

High-resolution gene expression profiling for simultaneous kinetic parameter analysis of RNA synthesis and decay

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4831063

Global regulation of nucleotide biosynthetic genes by c-Myc

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4831063

The highways and byways of mRNA decay

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4831063

Distinct organ-specific metastatic potential of individual breast cancer cells and primary tumors

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4831063

Myc regulates VEGF production in B cells by stimulating initiation of VEGF mRNA translation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4831063

Characterization of the BUD31 gene of Saccharomyces cerevisiae

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4831063

c-Myc recruits P-TEFb for transcription, cellular proliferation and apoptosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4831063

Control of cell growth by c-Myc in the absence of cell division

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4831063

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4831063

Evidence for nuclear factors involved in recognition of 5' splice sites.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4831063

6 July 2018

Identifiers

DOI

10.1038/NATURE14985

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26331541%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

1 June 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26331541%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

1 reference