(Q38057608)

27 August 2017

The spliceosome as a target of novel antitumour drugs (English)

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27 August 2017

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Luisa Vigevani

2

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Juan Valcárcel

object named as

Juan Valcárcel

series ordinal

3

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27 August 2017

Sophie Bonnal

1

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27 August 2017

1 November 2012

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Nature Reviews Drug Discovery

27 August 2017

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27 August 2017

11

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27 August 2017

847-859

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27 August 2017

11

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https://scigraph.springernature.com/pub.10.1038/nrd3823

27 August 2017

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cites work

Pre-mRNA processing reaches back to transcription and ahead to translation

1 reference

The spliceosome: design principles of a dynamic RNP machine

31 March 2020

1 reference

Alternative splicing: new insights from global analyses

31 March 2020

1 reference

Expansion of the eukaryotic proteome by alternative splicing

31 March 2020

1 reference

31 March 2020

1 reference

Functional consequences of developmentally regulated alternative splicing

31 March 2020

1 reference

Alternative pre-mRNA splicing regulation in cancer: pathways and programs unhinged

31 March 2020

1 reference

Splicing in oncogenesis and tumor suppression

31 March 2020

1 reference

Alternative splicing in lung cancer

31 March 2020

1 reference

VEGF-A splicing: the key to anti-angiogenic therapeutics?

31 March 2020

1 reference

Protection from Fas-mediated apoptosis by a soluble form of the Fas molecule

31 March 2020

1 reference

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

31 March 2020

1 reference

MDM2 and MDM4 splicing: an integral part of the cancer spliceome

31 March 2020

1 reference

RNA therapeutics: beyond RNA interference and antisense oligonucleotides

31 March 2020

1 reference

Antisense correction of SMN2 splicing in the CNS rescues necrosis in a type III SMA mouse model

31 March 2020

1 reference

Peripheral SMN restoration is essential for long-term rescue of a severe spinal muscular atrophy mouse model

31 March 2020

1 reference

New antitumor substances, FR901463, FR901464 and FR901465. II. Activities against experimental tumors in mice and mechanism of action

31 March 2020

1 reference

New antitumor substances, FR901463, FR901464 and FR901465. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities

31 March 2020

2 references

31 March 2020

12 December 2020

New antitumor substances, FR901463, FR901464 and FR901465. III. Structures of FR901463, FR901464 and FR901465

1 reference

Pladienolides, new substances from culture of Streptomyces platensis Mer-11107. III. In vitro and in vivo antitumor activities

31 March 2020

1 reference

Pladienolides, new substances from culture of Streptomyces platensis Mer-11107. II. Physico-chemical properties and structure elucidation

31 March 2020

1 reference

Pladienolides, new substances from culture of Streptomyces platensis Mer-11107. I. Taxonomy, fermentation, isolation and screening.

31 March 2020

1 reference

GEX1 compounds, novel antitumor antibiotics related to herboxidiene, produced by Streptomyces sp. II. The effects on cell cycle progression and gene expression.

31 March 2020

1 reference

GEX1 Compounds, Novel Antitumor Antibiotics Related to Herboxidiene, Produced by Streptomyces sp. I. Taxonomy, Production, Isolation, Physicochemical Properties and Biological Activities.

31 March 2020

1 reference

Meayamycin inhibits pre-messenger RNA splicing and exhibits picomolar activity against multidrug-resistant cells

31 March 2020

1 reference

Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA.

31 March 2020

1 reference

Splicing factor SF3b as a target of the antitumor natural product pladienolide.

31 March 2020

1 reference

Sudemycins, novel small molecule analogues of FR901464, induce alternative gene splicing

31 March 2020

1 reference

Synthetic mRNA splicing modulator compounds with in vivo antitumor activity

31 March 2020

1 reference

Antitumor compounds based on a natural product consensus pharmacophore

31 March 2020

1 reference

The development and application of small molecule modulators of SF3b as therapeutic agents for cancer.

31 March 2020

1 reference

Identification of SAP155 as the Target of GEX1A (Herboxidiene), an Antitumor Natural Product

31 March 2020

1 reference

Biological validation that SF3b is a target of the antitumor macrolide pladienolide

31 March 2020

1 reference

Reduced fidelity of branch point recognition and alternative splicing induced by the anti-tumor drug spliceostatin A

31 March 2020

1 reference

Spliceostatin A inhibits spliceosome assembly subsequent to prespliceosome formation

31 March 2020

1 reference

Real-time imaging of cotranscriptional splicing reveals a kinetic model that reduces noise: implications for alternative splicing regulation

31 March 2020

1 reference

Probing interactions between the U2 small nuclear ribonucleoprotein and the DEAD-box protein, Prp5.

31 March 2020

1 reference

Invariant U2 snRNA nucleotides form a stem loop to recognize the intron early in splicing.

31 March 2020

1 reference

The anti-tumor drug E7107 reveals an essential role for SF3b in remodeling U2 snRNP to expose the branch point-binding region

31 March 2020

1 reference

The zebrafish sf3b1b460 mutant reveals differential requirements for the sf3b1 pre-mRNA processing gene during neural crest development

31 March 2020

1 reference

Spliceosome assembly is coupled to RNA polymerase II dynamics at the 3' end of human genes

31 March 2020

1 reference

The in vivo kinetics of RNA polymerase II elongation during co-transcriptional splicing

31 March 2020

1 reference

Spliceostatin A blocks angiogenesis by inhibiting global gene expression including VEGF.

31 March 2020

1 reference

p53 is activated in response to disruption of the pre-mRNA splicing machinery.

31 March 2020

1 reference

Spliceosome mutations in hematopoietic malignancies

31 March 2020

1 reference

Association of TALS developmental disorder with defect in minor splicing component U4atac snRNA

31 March 2020

1 reference

Mutations in U4atac snRNA, a component of the minor spliceosome, in the developmental disorder MOPD I

31 March 2020

1 reference

Major Conformational Change in the Complex SF3b upon Integration into the Spliceosomal U11/U12 di-snRNP as Revealed by Electron Cryomicroscopy

31 March 2020

1 reference

SAP155 Binds to ceramide-responsive RNA cis-element 1 and regulates the alternative 5' splice site selection of Bcl-x pre-mRNA.

31 March 2020

1 reference

U2 snRNP binds intronless histone pre-mRNAs to facilitate U7-snRNP-dependent 3' end formation

31 March 2020

1 reference

Direct interactions between subunits of CPSF and the U2 snRNP contribute to the coupling of pre-mRNA 3' end processing and splicing.

31 March 2020

1 reference

Mechanisms and consequences of alternative polyadenylation

31 March 2020

1 reference

Heterogeneity in mammalian RNA 3' end formation

31 March 2020

1 reference

Mammalian polycomb-mediated repression of Hox genes requires the essential spliceosomal protein Sf3b1

31 March 2020

1 reference

The spliceosome as an indicted conspirator in myeloid malignancies

31 March 2020

1 reference

Mutations affecting mRNA splicing define distinct clinical phenotypes and correlate with patient outcome in myelodysplastic syndromes.

31 March 2020

1 reference

Emerging roles of the spliceosomal machinery in myelodysplastic syndromes and other hematological disorders

31 March 2020

1 reference

Molecular pathophysiology of myelodysplastic syndromes.

31 March 2020

1 reference

Myeloid malignancies: mutations, models and management

31 March 2020

1 reference

Spliceosome and other novel mutations in chronic lymphocytic leukemia and myeloid malignancies.

31 March 2020

1 reference

Mutations in the spliceosome machinery, a novel and ubiquitous pathway in leukemogenesis

31 March 2020

1 reference

Frequent pathway mutations of splicing machinery in myelodysplasia

31 March 2020

1 reference

Somatic SF3B1 mutation in myelodysplasia with ring sideroblasts

31 March 2020

1 reference

Spliceosomal gene aberrations are rare, coexist with oncogenic mutations, and are unlikely to exert a driver effect in childhood MDS and JMML

31 March 2020

1 reference

Long-term haematological improvement after non-intensive or no chemotherapy in juvenile myelomonocytic leukaemia and poor correlation with adult myelodysplasia spliceosome-related mutations

31 March 2020

1 reference

SF3B1 mutations in primary myelofibrosis: clinical, histopathology and genetic correlates among 155 patients

31 March 2020

1 reference

SF3B1, a splicing factor is frequently mutated in refractory anemia with ring sideroblasts

31 March 2020

1 reference

Clinical significance of SF3B1 mutations in myelodysplastic syndromes and myelodysplastic/myeloproliferative neoplasms

31 March 2020

1 reference

Clinical importance of SF3B1 mutations in Chinese with myelodysplastic syndromes with ring sideroblasts.

31 March 2020

1 reference

SF3B1 mutations are prevalent in myelodysplastic syndromes with ring sideroblasts but do not hold independent prognostic value

31 March 2020

1 reference

High frequencies of SF3B1 and JAK2 mutations in refractory anemia with ring sideroblasts associated with marked thrombocytosis strengthen the assignment to the category of myelodysplastic/myeloproliferative neoplasms

31 March 2020

1 reference

SF3B1 haploinsufficiency leads to formation of ring sideroblasts in myelodysplastic syndromes

31 March 2020

1 reference

Frequency and prognostic impact of mutations in SRSF2, U2AF1, and ZRSR2 in patients with myelodysplastic syndromes

31 March 2020

1 reference

Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia

31 March 2020

1 reference

SF3B1 and other novel cancer genes in chronic lymphocytic leukemia

31 March 2020

1 reference

Mutations of the SF3B1 splicing factor in chronic lymphocytic leukemia: association with progression and fludarabine-refractoriness

31 March 2020

1 reference

Chronic Lymphocytic Leukemia withSF3B1Mutation

31 March 2020

1 reference

A comprehensive catalogue of somatic mutations from a human cancer genome

31 March 2020

1 reference

The genomic landscapes of human breast and colorectal cancers

31 March 2020

1 reference

Whole-genome analysis informs breast cancer response to aromatase inhibition

31 March 2020

1 reference

Topological characteristics of helical repeat proteins

31 March 2020

1 reference

Structure of protein phosphatase 2A core enzyme bound to tumor-inducing toxins

31 March 2020

1 reference

Molecular Architecture of the Multiprotein Splicing Factor SF3b

31 March 2020

1 reference

Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes

31 March 2020

1 reference

The clinical implication of SRSF2 mutation in patients with myelodysplastic syndrome and its stability during disease evolution

31 March 2020

1 reference

Structural insights into translational fidelity

31 March 2020

1 reference

A quantitative high-throughput in vitro splicing assay identifies inhibitors of spliceosome catalysis

31 March 2020

1 reference

The biflavonoid isoginkgetin is a general inhibitor of Pre-mRNA splicing

31 March 2020

1 reference

Anticancer drugs affect the alternative splicing of Bcl-x and other human apoptotic genes

31 March 2020

1 reference

Widespread recognition of 5' splice sites by noncanonical base-pairing to U1 snRNA involving bulged nucleotides

31 March 2020

1 reference

Insights into branch nucleophile positioning and activation from an orthogonal pre-mRNA splicing system in yeast

31 March 2020

1 reference

A potential role for U2AF-SAP 155 interactions in recruiting U2 snRNP to the branch site

31 March 2020

1 reference

Reconstitution of both steps of Saccharomyces cerevisiae splicing with purified spliceosomal components

31 March 2020

1 reference

Release of SF3 from the intron branchpoint activates the first step of pre-mRNA splicing

31 March 2020

1 reference

Phosphorylation of spliceosomal protein SAP 155 coupled with splicing catalysis

31 March 2020

1 reference

Proofreading and spellchecking: a two-tier strategy for pre-mRNA splicing quality control

31 March 2020

1 reference

Splicing regulation: from a parts list of regulatory elements to an integrated splicing code

31 March 2020

1 reference

Mechanisms of alternative splicing regulation: insights from molecular and genomics approaches

31 March 2020

1 reference

Understanding splicing regulation through RNA splicing maps

31 March 2020

1 reference

Deciphering the splicing code

31 March 2020

1 reference

Degrade, move, regroup: signaling control of splicing proteins

31 March 2020

1 reference

Coupling transcription and alternative splicing.

31 March 2020

1 reference

Epigenetics in alternative pre-mRNA splicing

31 March 2020

1 reference

Alternative splicing interference by xenobiotics.

31 March 2020

1 reference

Isoginkgetin inhibits tumor cell invasion by regulating phosphatidylinositol 3-kinase/Akt-dependent matrix metalloproteinase-9 expression

31 March 2020

1 reference

A high-throughput screening strategy identifies cardiotonic steroids as alternative splicing modulators

31 March 2020

1 reference

The cardiotonic steroid digitoxin regulates alternative splicing through depletion of the splicing factors SRSF3 and TRA2B

31 March 2020

1 reference

Selective modification of alternative splicing by indole derivatives that target serine-arginine-rich protein splicing factors

31 March 2020

1 reference

Pro-metastatic splicing of Ron proto-oncogene mRNA can be reversed: therapeutic potential of bifunctional oligonucleotides and indole derivatives

31 March 2020

1 reference

Ser/Thr-specific protein phosphatases are required for both catalytic steps of pre-mRNA splicing

31 March 2020

1 reference

An in vivo reporter system for measuring increased inclusion of exon 7 in SMN2 mRNA: potential therapy of SMA

31 March 2020

1 reference

Synthesis and characterization of pseudocantharidins, novel phosphatase modulators that promote the inclusion of exon 7 into the SMN (survival of motoneuron) pre-mRNA

31 March 2020

1 reference

Manipulation of alternative splicing by a newly developed inhibitor of Clks

31 March 2020

1 reference

Chemical treatment enhances skipping of a mutated exon in the dystrophin gene

31 March 2020

1 reference

Utilization of host SR protein kinases and RNA-splicing machinery during viral replication

31 March 2020

1 reference

Small molecule amiloride modulates oncogenic RNA alternative splicing to devitalize human cancer cells

31 March 2020

1 reference

Amiloride modulates alternative splicing in leukemic cells and resensitizes Bcr-AblT315I mutant cells to imatinib

31 March 2020

1 reference

Rapid-response splicing reporter screens identify differential regulators of constitutive and alternative splicing.

31 March 2020

1 reference

Enantioselective total synthesis of pladienolide B: a potent spliceosome inhibitor

31 March 2020

1 reference

Structural requirements for the antiproliferative activity of pre-mRNA splicing inhibitor FR901464.

31 March 2020

1 reference

Spliceosome Structure and Function

31 March 2020

1 reference

PubMed

12 December 2020

GEX1 compounds, novel antitumor antibiotics related to herboxidiene, produced by Streptomyces sp. I. Taxonomy, production, isolation, physicochemical properties and biological activities

1 reference

PubMed

12 December 2020

Specific inhibition of serine- and arginine-rich splicing factors phosphorylation, spliceosome assembly, and splicing by the antitumor drug NB-506.

1 reference

PubMed

12 December 2020

Identifiers

DOI

10.1038/NRD3823

1 reference

27 August 2017

1 reference

PubMed ID

23123942