(Q34494886)

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The mRNA-binding protein HuR promotes hypoxia-induced chemoresistance through posttranscriptional regulation of the proto-oncogene PIM1 in pancreatic cancer cells.

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24 February 2020

The mRNA-binding protein HuR promotes hypoxia-induced chemoresistance through posttranscriptional regulation of the proto-oncogene PIM1 in pancreatic cancer cells (English)

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24 February 2020

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Isidore Rigoutsos

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J A Sawicki

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F F Blanco

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M Jimbo

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J Wulfkuhle

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I Gallagher

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J Deng

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L Enyenihi

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N Meisner-Kober

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M V Risbud

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A K Witkiewicz

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P A McCue

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W Jiang

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H Rui

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C J Yeo

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E Petricoin

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J M Winter

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J R Brody

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21 September 2015

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24 February 2020

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24 February 2020

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https://scigraph.springernature.com/pub.10.1038/onc.2015.325

0 references

Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.325

21 January 2018

FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer

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Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine

1 reference

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21 January 2018

Core signaling pathways in human pancreatic cancers revealed by global genomic analyses

1 reference

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21 January 2018

Models of carcinogenesis: an overview

1 reference

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Tumor morphology and phenotypic evolution driven by selective pressure from the microenvironment.

1 reference

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21 January 2018

Tumor hypoxia correlates with metastatic tumor growth of pancreatic cancer in an orthotopic murine model

1 reference

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21 January 2018

Hypoxia enhances vascular cell proliferation and angiogenesis in vitro via rapamycin (mTOR)-dependent signaling

1 reference

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21 January 2018

Tumor cycling hypoxia induces chemoresistance in glioblastoma multiforme by upregulating the expression and function of ABCB1

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21 January 2018

TMEM45A is essential for hypoxia-induced chemoresistance in breast and liver cancer cells

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Impact of tumor hypoxia and anemia on radiation therapy outcomes

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Severe hypoxia induces chemo-resistance in clinical cervical tumors through MVP over-expression.

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Growth and survival mechanisms associated with perineural invasion in prostate cancer

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Activation of the Wnt pathway plays a pathogenic role in diabetic retinopathy in humans and animal models

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21 January 2018

Pim-1 plays a pivotal role in hypoxia-induced chemoresistance.

1 reference

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21 January 2018

Pim-1 kinase expression predicts radiation response in squamocellular carcinoma of head and neck and is under the control of epidermal growth factor receptor.

1 reference

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21 January 2018

Why target PIM1 for cancer diagnosis and treatment?

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.325

21 January 2018

HNS, a nuclear-cytoplasmic shuttling sequence in HuR

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.325

21 January 2018

HuR and mRNA stability

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.325

21 January 2018

HuR is a post-transcriptional regulator of core metabolic enzymes in pancreatic cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.325

21 January 2018

HuR posttranscriptionally regulates WEE1: implications for the DNA damage response in pancreatic cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.325

21 January 2018

High expression of HuR in cytoplasm, but not nuclei, is associated with malignant aggressiveness and prognosis in bladder cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.325

21 January 2018

The mRNA binding proteins HuR and tristetraprolin regulate cyclooxygenase 2 expression during colon carcinogenesis

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.325

21 January 2018

Hypoxia-induced resistance to anticancer drugs is associated with decreased senescence and requires hypoxia-inducible factor-1 activity

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.325

21 January 2018

Posttranscriptional regulation of cancer traits by HuR

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.325

21 January 2018

The role of HuR in gemcitabine efficacy in pancreatic cancer: HuR Up-regulates the expression of the gemcitabine metabolizing enzyme deoxycytidine kinase.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.325

21 January 2018

The RNA-binding protein HuR stabilizes cytosolic phospholipase A2α mRNA under interleukin-1β treatment in non-small cell lung cancer A549 Cells

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.325

21 January 2018

Integrative regulatory mapping indicates that the RNA-binding protein HuR couples pre-mRNA processing and mRNA stability

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.325

21 January 2018

A quantitative analysis of CLIP methods for identifying binding sites of RNA-binding proteins

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.325

21 January 2018

HuR's post-transcriptional regulation of Death Receptor 5 in pancreatic cancer cells.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.325

21 January 2018

Post-transcriptional control of cyclooxygenase-2 gene expression. The role of the 3'-untranslated region

1 reference

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Systems analysis of the NCI-60 cancer cell lines by alignment of protein pathway activation modules with "-OMIC" data fields and therapeutic response signatures

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21 January 2018

Protein pathway activation mapping of brain metastasis from lung and breast cancers reveals organ type specific drug target activation

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https://api.crossref.org/works/10.1038%2FONC.2015.325

21 January 2018

Pim-1 kinase promotes inactivation of the pro-apoptotic Bad protein by phosphorylating it on the Ser112 gatekeeper site

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.325

21 January 2018

Post-transcriptional regulation of the DUSP6/MKP-3 phosphatase by MEK/ERK signaling and hypoxia.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.325

21 January 2018

The oncogenic serine/threonine kinase Pim-1 phosphorylates and inhibits the activity of Cdc25C-associated kinase 1 (C-TAK1): a novel role for Pim-1 at the G2/M cell cycle checkpoint

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.325

21 January 2018

Physical and functional interactions between Pim-1 kinase and Cdc25A phosphatase. Implications for the Pim-1-mediated activation of the c-Myc signaling pathway

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.325

21 January 2018

Identification and mechanistic characterization of low-molecular-weight inhibitors for HuR

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.325

21 January 2018

Hypoxia induces chemoresistance in ovarian cancer cells by activation of signal transducer and activator of transcription 3.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.325

21 January 2018

Notch1 is required for hypoxia-induced proliferation, invasion and chemoresistance of T-cell acute lymphoblastic leukemia cells

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21 January 2018

The oncogenic kinase Pim-1 is modulated by K-Ras signaling and mediates transformed growth and radioresistance in human pancreatic ductal adenocarcinoma cells

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.325

21 January 2018

Pim-1 kinase stability is regulated by heat shock proteins and the ubiquitin-proteasome pathway

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.325

21 January 2018

Pim1 kinase synergizes with c-MYC to induce advanced prostate carcinoma

1 reference

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21 January 2018

Post-transcriptional regulation of MEK-1 by polyamines through the RNA-binding protein HuR modulating intestinal epithelial apoptosis

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21 January 2018

Pim kinase inhibitor, SGI-1776, induces apoptosis in chronic lymphocytic leukemia cells

1 reference

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21 January 2018

Increased expression of the hPim-2 gene in human chronic lymphocytic leukemia and non-Hodgkin lymphoma

1 reference

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21 January 2018

Ki67 and PIM1 expression predict outcome in mantle cell lymphoma treated with high dose therapy, stem cell transplantation and rituximab: a Cancer and Leukemia Group B 59909 correlative science study

1 reference

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21 January 2018

Protein synthesis is resistant to rapamycin and constitutes a promising therapeutic target in acute myeloid leukemia.

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Investigatory and analytical approaches to differential gene expression profiling in mantle cell lymphoma.

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https://api.crossref.org/works/10.1038%2FONC.2015.325

21 January 2018

Pim-1 is up-regulated by shear stress and is involved in shear stress-induced proliferation of rat mesenchymal stem cells.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.325

21 January 2018

HuR status is a powerful marker for prognosis and response to gemcitabine-based chemotherapy for resected pancreatic ductal adenocarcinoma patients

1 reference

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21 January 2018

HuR's role in gemcitabine efficacy: an exception or opportunity?

1 reference

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21 January 2018

HuR keeps an angiogenic switch on by stabilising mRNA of VEGF and COX-2 in tumour endothelium

1 reference

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21 January 2018

Identification and validation of novel small molecule disruptors of HuR-mRNA interaction

1 reference

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21 January 2018

Essential role of the RNA-binding protein HuR in progenitor cell survival in mice.

1 reference

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Myeloid cell expression of the RNA-binding protein HuR protects mice from pathologic inflammation and colorectal carcinogenesis

1 reference

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21 January 2018

RNA-binding protein HuR promotes growth of small intestinal mucosa by activating the Wnt signaling pathway

1 reference

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21 January 2018

HuR Suppresses Fas Expression and Correlates with Patient Outcome in Liver Cancer.

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21 January 2018

Posttranscriptional Regulation of Cyclooxygenase 2 Expression in Colorectal Cancer

1 reference

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21 January 2018

The RNA binding protein HuR differentially regulates unique subsets of mRNAs in estrogen receptor negative and estrogen receptor positive breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.325

21 January 2018

Transforming growth factor β regulates P-body formation through induction of the mRNA decay factor tristetraprolin

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.325

21 January 2018

MUC1 Promoter-Driven DTA as a Targeted Therapeutic Strategy against Pancreatic Cancer

1 reference

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21 January 2018

The mRNA stability factor HuR inhibits microRNA-16 targeting of COX-2.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.325

21 January 2018

Hypoxia-inducible proto-oncogene Pim-1 is a prognostic marker in pancreatic ductal adenocarcinoma

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.325

21 January 2018

Pancreatic tumors show high levels of hypoxia

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.325

31 March 2020

Hypoxia Predicts Aggressive Growth and Spontaneous Metastasis Formation from Orthotopically Grown Primary Xenografts of Human Pancreatic Cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.325

31 March 2020

Hypoxia-mediated up-regulation of Pim-1 contributes to solid tumor formation

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.325

31 March 2020

Altered expression of the mRNA stability factor HuR promotes cyclooxygenase-2 expression in colon cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.325

31 March 2020

Primary mediastinal large B-cell lymphoma

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.325

31 March 2020

IL-6 stimulates STAT3 and Pim-1 kinase in pancreatic cancer cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/26387536

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HuR, a RNA stability factor, is expressed in malignant brain tumors and binds to adenine- and uridine-rich elements within the 3' untranslated regions of cytokine and angiogenic factor mRNAs

1 reference

https://pubmed.ncbi.nlm.nih.gov/26387536

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1038/ONC.2015.325

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Europe PubMed Central

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24 February 2020

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24 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26387536%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

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