(Q34498309)

2 August 2017

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title

NXY-059: review of neuroprotective potential for acute stroke (English)

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2 August 2017

Jeffrey J Fong

1

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2 August 2017

Denise H Rhoney

series ordinal

2

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2 August 2017

language of work or name

English

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publication date

28 February 2006

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Annals of Pharmacotherapy

2 August 2017

published in

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2 August 2017

volume

40

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2 August 2017

issue

3

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2 August 2017

page(s)

461-471

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Why do neuroprotective drugs that are so promising in animals fail in the clinic? An industry perspective

2 August 2017

cites work

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Recommendations for standards regarding preclinical neuroprotective and restorative drug development

21 January 2018

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Antiepileptic drugs as a possible neuroprotective strategy in brain ischemia

21 January 2018

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Mechanisms of action of neuroprotectants in stroke

21 January 2018

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Oxidants, antioxidants and the ischemic brain

21 January 2018

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Nitrones as neuroprotective agents in cerebral ischemia, with particular reference to NXY-059.

21 January 2018

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Comparison of the radical trapping ability of PBN, S-PPBN and NXY-059.

21 January 2018

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Reactive oxygen radicals in signaling and damage in the ischemic brain

21 January 2018

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Effect of NXY-059 on secondary mitochondrial dysfunction after transient focal ischemia; comparison with cyclosporin A.

21 January 2018

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Effect of NXY-059 on infarct volume after transient or permanent middle cerebral artery occlusion in the rat; studies on dose, plasma concentration and therapeutic time window

21 January 2018

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Neuroprotective effects of a novel nitrone, NXY-059, after transient focal cerebral ischemia in the rat.

21 January 2018

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NXY-059, a novel free radical trapping compound, reduces cortical infarction after permanent focal cerebral ischemia in the rat.

21 January 2018

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Functional and histological evidence for the protective effect of NXY-059 in a primate model of stroke when given 4 hours after occlusion

21 January 2018

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Efficacy of disodium 4-[(tert-butylimino)methyl]benzene-1,3-disulfonate N-oxide (NXY-059), a free radical trapping agent, in a rat model of hemorrhagic stroke

21 January 2018

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Effects of the spin trap agent disodium- [tert-butylimino)methyl]benzene-1,3-disulfonate N-oxide (generic NXY-059) on intracerebral hemorrhage in a rabbit Large clot embolic stroke model: combination studies with tissue plasminogen activator

21 January 2018

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Nitronyl nitroxides, a novel group of protective agents against oxidative stress in endothelial cells forming the blood-brain barrier

21 January 2018

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Neutrophil inhibitory factor treatment of focal cerebral ischemia in the rat.

21 January 2018

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Reduction of central nervous system ischemic injury by monoclonal antibody to intercellular adhesion molecule

21 January 2018

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NXY-059, a free radical--trapping agent, substantially lessens the functional disability resulting from cerebral ischemia in a primate species

21 January 2018

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Comparison of the neuroprotective effect of clomethiazole, AR-R15896AR and NXY-059 in a primate model of stroke using histological and behavioural measures

21 January 2018

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In vitro blood-brain barrier permeability and cerebral endothelial cell uptake of the neuroprotective nitrone compound NXY-059 in normoxic, hypoxic and ischemic conditions

21 January 2018

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Dynamics of cerebral injury, perfusion, and blood-brain barrier changes after temporary and permanent middle cerebral artery occlusion in the rat.

21 January 2018

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NXY-059 maintains Akt activation and inhibits release of cytochrome C after focal cerebral ischemia.

21 January 2018

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Pharmacokinetics of NXY-059, a nitrone-based free radical trapping agent, in healthy young and elderly subjects

21 January 2018

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Pharmacokinetics in renally impaired subjects of NXY-059, a nitrone-based, free-radical trapping agent developed for the treatment of acute stroke

21 January 2018

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Tolerability and pharmacokinetics of the nitrone NXY-059 in patients with acute stroke

21 January 2018

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Tolerability of NXY-059 at higher target concentrations in patients with acute stroke

21 January 2018

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NXY-059 for acute ischemic stroke

21 January 2018

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Pharmacokinetic interaction between high-dose methotrexate and amoxycillin

21 January 2018

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Potentially Significant Drug Interactions of Class III Antiarrhythmic Drugs

21 January 2018

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Neuroprotective effects of the spin trap agent disodium-[(tert-butylimino)methyl]benzene-1,3-disulfonate N-oxide (generic NXY-059) in a rabbit small clot embolic stroke model: combination studies with the thrombolytic tissue plasminogen activator

21 January 2018

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Extending the window for acute stroke treatment: thrombolytics plus CNS protective therapies.

21 January 2018

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Coadministration of NXY-059 and tenecteplase six hours following embolic strokes in rabbits improves clinical rating scores

21 January 2018

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21 January 2018

Identifiers

DOI

10.1345/APH.1E636

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2 August 2017

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