(Q44100874)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12176160%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

title

NXY-059 maintains Akt activation and inhibits release of cytochrome C after focal cerebral ischemia (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12176160%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

1 reference

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12176160%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

8

Bo K Siesjö

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12176160%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

author name string

Tetsuyuki Yoshimoto

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12176160%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

Palanisamy Kanakaraj

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12176160%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

Jing Ying Ma

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12176160%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

Mingshan Cheng

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12176160%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

Irene Kerr

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12176160%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

Jenny A Watson

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12176160%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

Kirk R Maples

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12176160%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

language of work or name

English

0 references

publication date

1 August 2002

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12176160%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12176160%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

volume

947

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12176160%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

issue

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12176160%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

page(s)

191-198

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12176160%20AND%20SRC:MED&resulttype=core&format=json

Glutamate-induced neuronal death: A succession of necrosis or apoptosis depending on mitochondrial function

12 November 2019

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2802%2902922-0

PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2802%2902922-0

The Trk family of neurotrophin receptors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2802%2902922-0

Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2802%2902922-0

The permeability transition pore. Control points of a cyclosporin A-sensitive mitochondrial channel involved in cell death

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2802%2902922-0

The activation of p38 and apoptosis by the inhibition of Erk is antagonized by the phosphoinositide 3-kinase/Akt pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2802%2902922-0

alpha-Phenyl-tert-butyl-nitrone reduces cortical infarct and edema in rats subjected to focal ischemia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2802%2902922-0

Phosphatidylinositol 3-kinase and Akt protein kinase are necessary and sufficient for the survival of nerve growth factor-dependent sympathetic neurons.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2802%2902922-0

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2802%2902922-0

Insulin-like growth factor and potassium depolarization maintain neuronal survival by distinct pathways: possible involvement of PI 3-kinase in IGF-1 signaling.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2802%2902922-0

Akt, a target of phosphatidylinositol 3-kinase, inhibits apoptosis in a differentiating neuronal cell line

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2802%2902922-0

N-tert-butyl-alpha-phenylnitrone improves recovery of brain energy state in rats following transient focal ischemia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2802%2902922-0

Cytosolic redistribution of cytochrome c after transient focal cerebral ischemia in rats.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2802%2902922-0

Mitochondria and apoptosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2802%2902922-0

The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2802%2902922-0

Immunoreactive Akt, PI3-K and ERK protein kinase expression in ischemic rat brain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2802%2902922-0

The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2802%2902922-0

The mitochondrial death/life regulator in apoptosis and necrosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2802%2902922-0

Neuroprotective effects of a novel nitrone, NXY-059, after transient focal cerebral ischemia in the rat.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2802%2902922-0

Tolerability and pharmacokinetics of the nitrone NXY-059 in patients with acute stroke

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2802%2902922-0

Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2802%2902922-0

Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2802%2902922-0

Reversible middle cerebral artery occlusion without craniectomy in rats

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2802%2902922-0

Comparison of the radical trapping ability of PBN, S-PPBN and NXY-059.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2802%2902922-0

NXY-059, a free radical--trapping agent, substantially lessens the functional disability resulting from cerebral ischemia in a primate species

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2802%2902922-0

Bcl-x(L) forms an ion channel in synthetic lipid membranes.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2802%2902922-0

Survival- and death-promoting events after transient cerebral ischemia: phosphorylation of Akt, release of cytochrome C and Activation of caspase-like proteases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2802%2902922-0

Mitochondrial membrane potential and nuclear changes in apoptosis caused by serum and nerve growth factor withdrawal: time course and modification by (-)-deprenyl.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2802%2902922-0

Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2802%2902922-0

Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2802%2902922-0

Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2802%2902922-0

Posttreatment with the immunosuppressant cyclosporin A in transient focal ischemia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2802%2902922-0

Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2802%2902922-0

Delayed treatment with the spin trap alpha-phenyl-N-tert-butyl nitrone (PBN) reduces infarct size following transient middle cerebral artery occlusion in rats

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2802%2902922-0

Delayed treatment with alpha-phenyl-N-tert-butyl nitrone (PBN) attenuates secondary mitochondrial dysfunction after transient focal cerebral ischemia in the rat.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2802%2902922-0

10.1016/S0006-8993(02)02922-0

7 January 2021

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12176160%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

1 reference