(Q34501913)

2 August 2017

title

mTORC1/2 and rapamycin in female Han:SPRD rats with polycystic kidney disease (English)

1 reference

2 August 2017

1 reference

Franck Belibi

1

1 reference

2 August 2017

Kameswaran Ravichandran

2

1 reference

2 August 2017

Iram Zafar

3

1 reference

2 August 2017

Zhibin He

4

1 reference

2 August 2017

Charles L Edelstein

5

1 reference

2 August 2017

publication date

13 October 2010

1 reference

American Journal of Physiology - Renal Physiology

2 August 2017

published in

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2 August 2017

volume

300

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2 August 2017

issue

1

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2 August 2017

page(s)

F236-44

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Emerging evidence of a link between the polycystins and the mTOR pathways

2 August 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3023230

Characterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3023230

Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3023230

Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3023230

Mechanisms of Disease: autosomal dominant and recessive polycystic kidney diseases

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3023230

Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3023230

The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3023230

TOR signaling in growth and metabolism

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3023230

What is the role of tubular epithelial cell apoptosis in polycystic kidney disease (PKD)?

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3023230

Androgen receptor pathway in rats with autosomal dominant polycystic kidney disease

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3023230

Caspase inhibition reduces tubular apoptosis and proliferation and slows disease progression in polycystic kidney disease

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3023230

A Ras activation pathway dependent on Syk phosphorylation of protein kinase C

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3023230

New insights into the molecular pathophysiology of polycystic kidney disease

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3023230

Polycystic kidney disease in SBM transgenic mice: role of c-myc in disease induction and progression.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3023230

Targeting of the rasT24 oncogene to the proximal convoluted tubules in transgenic mice results in hyperplasia and polycystic kidneys

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3023230

Elevated c-myc protooncogene expression in autosomal recessive polycystic kidney disease

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3023230

Mitogen-activated 70K S6 kinase. Identification of in vitro 40 S ribosomal S6 phosphorylation sites

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3023230

c-myc as an inducer of polycystic kidney disease in transgenic mice

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3023230

New insights into mTOR signaling: mTORC2 and beyond

7 July 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00129.2010

Gender and the effect of gonadal hormones on the progression of inherited polycystic kidney disease in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00129.2010

Caspase-1-deficient mice are protected against cisplatin-induced apoptosis and acute tubular necrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00129.2010

Activation of the AKT/mTOR pathway in autosomal recessive polycystic kidney disease (ARPKD).

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00129.2010

Activation of protein kinase C-alpha is essential for stimulation of cell proliferation by ceramide 1-phosphate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00129.2010

Increased apoptosis and proliferative capacity are early events in cyst formation in autosomal-dominant, polycystic kidney disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00129.2010

Azotemia and extrarenal manifestations in old female Han:SPRD (cy/+) rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00129.2010

Characterization of the Han:SPRD rat model for hereditary polycystic kidney disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00129.2010

Gender hormones and the progression of experimental polycystic kidney disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00129.2010

Rapamycin markedly slows disease progression in a rat model of polycystic kidney disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00129.2010

Inhibition of mTOR with sirolimus slows disease progression in Han:SPRD rats with autosomal dominant polycystic kidney disease (ADPKD).

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00129.2010

Long-term rapamycin therapy in the Han:SPRD rat model of polycystic kidney disease (PKD).

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00129.2010

Increased epithelial cell proliferation and abnormal extracellular matrix in rat polycystic kidney disease

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3023230

Analysis of the role of apoptosis and cell proliferation in renal cystic disorders

27 October 2018

1 reference

12 December 2020

Elevated proto-oncogene expression in polycystic kidneys of the C57BL/6J (cpk) mouse

1 reference

12 December 2020

Polycystic kidney disease

1 reference

12 December 2020

Strategies to inhibit cyst formation in ADPKD

1 reference

12 December 2020

Everolimus retards cyst growth and preserves kidney function in a rodent model for polycystic kidney disease

1 reference

12 December 2020

Autosomal-dominant polycystic kidney disease in the rat

1 reference

12 December 2020

Substrate recognition determinants of the mitogen-activated 70K S6 kinase from rat liver

1 reference

12 December 2020

Downregulation of the calpain inhibitor protein calpastatin by caspases during renal ischemia-reperfusion

1 reference

12 December 2020

10.1152/AJPRENAL.00129.2010

Identifiers

DOI

1 reference

2 August 2017

1 reference

2 August 2017

1 reference