(Q46142296)

19 December 2017

title

Activation of the AKT/mTOR pathway in autosomal recessive polycystic kidney disease (ARPKD). (English)

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19 December 2017

autosomal recessive polycystic kidney

main subject

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author

Dagmar-Christiane Fischer

1

object named as

Dagmar-Christiane Fischer

1 reference

19 December 2017

author name string

Ulrike Jacoby

2

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19 December 2017

Lars Pape

3

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19 December 2017

Christopher J Ward

4

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19 December 2017

Eberhard Kuwertz-Broeking

5

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19 December 2017

Catharina Renken

6

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19 December 2017

Horst Nizze

7

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19 December 2017

Uwe Querfeld

8

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19 December 2017

Birgit Rudolph

9

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19 December 2017

Dirk E Mueller-Wiefel

10

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19 December 2017

Carsten Bergmann

11

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19 December 2017

Dieter Haffner

12

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19 December 2017

language of work or name

English

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publication date

28 January 2009

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19 December 2017

Nephrology Dialysis Transplantation

published in

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19 December 2017

volume

24

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19 December 2017

issue

6

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19 December 2017

page(s)

1819-1827

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19 December 2017

Diagnosis, pathogenesis, and treatment prospects in cystic kidney disease

cites work

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFN744

Molecular and cellular pathophysiology of autosomal recessive polycystic kidney disease (ARPKD).

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFN744

Functional analysis of PKHD1 splicing in autosomal recessive polycystic kidney disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFN744

Fibrocystin interacts with CAML, a protein involved in Ca2+ signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFN744

Proteolytic cleavage and nuclear translocation of fibrocystin is regulated by intracellular Ca2+ and activation of protein kinase C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFN744

Molecular basis of polycystic kidney disease: PKD1, PKD2 and PKHD1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFN744

The gene mutated in autosomal recessive polycystic kidney disease encodes a large, receptor-like protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFN744

Autosomal dominant polycystic kidney disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFN744

Polycystic kidney disease: genes, proteins, animal models, disease mechanisms and therapeutic opportunities

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFN744

Kinesin-2 mediates physical and functional interactions between polycystin-2 and fibrocystin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFN744

Genetic interaction studies link autosomal dominant and recessive polycystic kidney disease in a common pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFN744

Fibrocystin/polyductin, found in the same protein complex with polycystin-2, regulates calcium responses in kidney epithelia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFN744

Fibrocystin/polyductin modulates renal tubular formation by regulating polycystin-2 expression and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFN744

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFN744

Cystic kidney diseases: all roads lead to the cilium

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFN744

Epidermal growth factor receptor tyrosine kinase inhibition is not protective in PCK rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFN744

Upstream of the mammalian target of rapamycin: do all roads pass through mTOR?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFN744

Stress and mTORture signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFN744

The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFN744

mTOR is out of control in polycystic kidney disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFN744

Inhibition of mTOR with sirolimus slows disease progression in Han:SPRD rats with autosomal dominant polycystic kidney disease (ADPKD).

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFN744

Polycystic kidney diseases: from molecular discoveries to targeted therapeutic strategies

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFN744

When translation meets transformation: the mTOR story

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFN744

Dysregulation of the TSC-mTOR pathway in human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFN744

Upstream and downstream of mTOR

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFN744

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFN744

Renal cystic disease: new insights for the clinician

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFN744

PKHD1 mutations in autosomal recessive polycystic kidney disease (ARPKD).

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFN744

Expression of the transcriptional coregulator FHL2 in human breast cancer: a clinicopathologic study

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFN744

Spectrum of mutations in the gene for autosomal recessive polycystic kidney disease (ARPKD/PKHD1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFN744

Algorithm for efficient PKHD1 mutation screening in autosomal recessive polycystic kidney disease (ARPKD).

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFN744

Multi-exon deletions of the PKHD1 gene cause autosomal recessive polycystic kidney disease (ARPKD).

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFN744

PKHD1, the polycystic kidney and hepatic disease 1 gene, encodes a novel large protein containing multiple immunoglobulin-like plexin-transcription-factor domains and parallel beta-helix 1 repeats

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFN744

Cellular and subcellular localization of the ARPKD protein; fibrocystin is expressed on primary cilia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFN744

Molecular pathogenesis of ADPKD: the polycystin complex gets complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFN744

Polyductin undergoes notch-like processing and regulated release from primary cilia

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFN744

The polycystic kidney disease proteins, polycystin-1, polycystin-2, polaris, and cystin, are co-localized in renal cilia

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFN744

Loss of primary cilia results in deregulated and unabated apical calcium entry in ARPKD collecting duct cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFN744

Mechanisms of Disease: autosomal dominant and recessive polycystic kidney diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFN744

A plethora of epidermal growth factor-like proteins in polycystic kidneys

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFN744

The mTOR pathway in the control of protein synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFN744

TOR signaling in growth and metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFN744

Signalling to translation: how signal transduction pathways control the protein synthetic machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFN744

Combination treatment of PKD utilizing dual inhibition of EGF-receptor activity and ligand bioavailability

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFN744

Treatment of polycystic liver disease: one size does not fit all.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFN744

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFN744

Regulation of the p70 S6 kinase by phosphorylation in vivo. Analysis using site-specific anti-phosphopeptide antibodies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFN744

21 January 2018

Identifiers

DOI

10.1093/NDT/GFN744

1 reference

19 December 2017

PubMed ID

19176689

1 reference

19 December 2017