(Q36707529)

15 August 2017

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title

Polycystic kidney disease: genes, proteins, animal models, disease mechanisms and therapeutic opportunities (English)

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polycystic kidney disease

15 August 2017

main subject

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Torres VE

1

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15 August 2017

Harris PC

series ordinal

2

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15 August 2017

language of work or name

English

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publication date

1 January 2007

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Journal of Internal Medicine

15 August 2017

published in

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15 August 2017

volume

261

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15 August 2017

issue

1

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15 August 2017

page(s)

17-31

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The polycystic kidney disease 1 (PKD1) gene encodes a novel protein with multiple cell recognition domains

15 August 2017

cites work

1 reference

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Polycystic kidney disease: The complete structure of the PKD1 gene and its protein

21 January 2018

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PKD2, a gene for polycystic kidney disease that encodes an integral membrane protein

21 January 2018

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Characterization of the exon structure of the polycystic kidney disease 2 gene (PKD2)

21 January 2018

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PKD1 interacts with PKD2 through a probable coiled-coil domain

21 January 2018

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Homo- and heterodimeric interactions between the gene products of PKD1 and PKD2

21 January 2018

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Polycystin-1 interacts with intermediate filaments

21 January 2018

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The polycystic kidney disease-1 protein, polycystin-1, binds and activates heterotrimeric G-proteins in vitro

21 January 2018

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Genetics and pathogenesis of polycystic kidney disease.

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Human disease: calcium signaling in polycystic kidney disease

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The gene mutated in autosomal recessive polycystic kidney disease encodes a large, receptor-like protein

21 January 2018

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PKHD1, the polycystic kidney and hepatic disease 1 gene, encodes a novel large protein containing multiple immunoglobulin-like plexin-transcription-factor domains and parallel beta-helix 1 repeats

21 January 2018

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Intraflagellar transport and cilia-dependent diseases.

21 January 2018

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The polycystic kidney disease proteins, polycystin-1, polycystin-2, polaris, and cystin, are co-localized in renal cilia

21 January 2018

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Cellular and subcellular localization of the ARPKD protein; fibrocystin is expressed on primary cilia.

21 January 2018

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Biliary dysgenesis in the PCK rat, an orthologous model of autosomal recessive polycystic kidney disease

21 January 2018

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Cyclic AMP promotes growth and secretion in human polycystic kidney epithelial cells

21 January 2018

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A transcriptional network in polycystic kidney disease

21 January 2018

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PKD2 interacts and co-localizes with mDia1 to mitotic spindles of dividing cells: role of mDia1 IN PKD2 localization to mitotic spindles

21 January 2018

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Pkd2 haploinsufficiency alters intracellular calcium regulation in vascular smooth muscle cells

21 January 2018

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Drosophila Pkd2 is haploid-insufficient for mediating optimal smooth muscle contractility

21 January 2018

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Depletion of PKD1 by an antisense oligodeoxynucleotide induces premature G1/S-phase transition

21 January 2018

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Haploinsufficiency of Pkd2 is associated with increased tubular cell proliferation and interstitial fibrosis in two murine Pkd2 models.

21 January 2018

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The pck rat: a new model that resembles human autosomal dominant polycystic kidney and liver disease

21 January 2018

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Mutations in a novel gene, NPHP3, cause adolescent nephronophthisis, tapeto-retinal degeneration and hepatic fibrosis

21 January 2018

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Polycystin-2 is an intracellular calcium release channel

21 January 2018

1 reference

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Polycystin-2 is a novel cation channel implicated in defective intracellular Ca(2+) homeostasis in polycystic kidney disease

21 January 2018

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Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells

21 January 2018

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Mechanisms of regulating the Raf kinase family

21 January 2018

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Functional properties of Ca2+-inhibitable type 5 and type 6 adenylyl cyclases and role of Ca2+ increase in the inhibition of intracellular cAMP content

21 January 2018

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Inhibition by calcium of mammalian adenylyl cyclases

21 January 2018

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Capacitative Ca2+ entry exclusively inhibits cAMP synthesis in C6-2B glioma cells. Evidence that physiologically evoked Ca2+ entry regulates Ca(2+)-inhibitable adenylyl cyclase in non-excitable cells.

21 January 2018

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Reciprocal regulation of calcium dependent and calcium independent cyclic AMP hydrolysis by protein phosphorylation

21 January 2018

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Intranephron localization and regulation of the V1a vasopressin receptor during chronic metabolic acidosis and dehydration in rats

21 January 2018

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Renal activation of extracellular signal-regulated kinase in rats with autosomal-dominant polycystic kidney disease

21 January 2018

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In vivo effects of activated H-ras oncogene expressed in the liver and in urogenital tissues.

21 January 2018

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Molecular genetic analysis of von Hippel-Lindau disease

21 January 2018

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Protein kinase A-dependent and -independent signaling pathways contribute to cyclic AMP-stimulated proliferation.

21 January 2018

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Cell type-specific regulation of B-Raf kinase by cAMP and 14-3-3 proteins

21 January 2018

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Cell condition-dependent regulation of ERK5 by cAMP.

21 January 2018

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Cyclic AMP differentially regulates cell proliferation of normal human keratinocytes through ERK activation depending on the expression pattern of B-Raf

21 January 2018

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New signaling pathway for parathyroid hormone and cyclic AMP action on extracellular-regulated kinase and cell proliferation in bone cells. Checkpoint of modulation by cyclic AMP.

21 January 2018

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[Ca2+]i reduction increases cellular proliferation and apoptosis in vascular smooth muscle cells: relevance to the ADPKD phenotype

21 January 2018

1 reference

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Cyclic AMP activates B-Raf and ERK in cyst epithelial cells from autosomal-dominant polycystic kidneys

21 January 2018

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Mechanisms of Disease: autosomal dominant and recessive polycystic kidney diseases

21 January 2018

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Cleavage of polycystin-1 requires the receptor for egg jelly domain and is disrupted by human autosomal-dominant polycystic kidney disease 1-associated mutations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2796.2006.01743.X

Polycystin-1, STAT6, and P100 function in a pathway that transduces ciliary mechanosensation and is activated in polycystic kidney disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2796.2006.01743.X

Treatment prospects for autosomal-dominant polycystic kidney disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2796.2006.01743.X

Defective epidermal growth factor gene expression in mice with polycystic kidney disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2796.2006.01743.X

Expression of differentiation antigens and growth-related genes in normal kidney, autosomal dominant polycystic kidney disease, and renal cell carcinoma

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1365-2796.2006.01743.X

Primary degenerative mild cognitive impairment: study population, clinical, brain imaging and biochemical findings

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1365-2796.2006.01743.X

In vitro modulation of cyst formation by a novel tyrosine kinase inhibitor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2796.2006.01743.X

An activated allele of the c-erbB-2 oncogene impairs kidney and lung function and causes early death of transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2796.2006.01743.X

EGF receptor tyrosine kinase inhibition attenuates the development of PKD in Han:SPRD rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2796.2006.01743.X

Epidermal growth factor receptor tyrosine kinase inhibition is not protective in PCK rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2796.2006.01743.X

Inhibition of HER-2(neu/ErbB2) restores normal function and structure to polycystic kidney disease (PKD) epithelia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2796.2006.01743.X

Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2796.2006.01743.X

The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2796.2006.01743.X

Rapamycin markedly slows disease progression in a rat model of polycystic kidney disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2796.2006.01743.X

Inhibition of mTOR with sirolimus slows disease progression in Han:SPRD rats with autosomal dominant polycystic kidney disease (ADPKD).

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2796.2006.01743.X

Safety and efficacy of long-acting somatostatin treatment in autosomal-dominant polycystic kidney disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2796.2006.01743.X

10.1111/J.1365-2796.2006.01743.X

21 January 2018

Identifiers

DOI

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15 August 2017

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