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High-fidelity CRISPR-Cas9 nucleases with no detectable genome-wide off-target effects.
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Europe PubMed Central
PMC publication ID
4851738
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26735016%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 March 2020
title
High-fidelity CRISPR-Cas9 nucleases with no detectable genome-wide off-target effects
(English)
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PMC publication ID
4851738
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26735016%20AND%20SRC:MED&resulttype=core&format=json
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4 March 2020
main subject
CRISPR
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Cas9
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author
Benjamin P Kleinstiver
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1
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Europe PubMed Central
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4851738
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26735016%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 March 2020
Zongli Zheng
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6
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4851738
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26735016%20AND%20SRC:MED&resulttype=core&format=json
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4 March 2020
J. Keith Joung
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7
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J Keith Joung
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PMC publication ID
4851738
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26735016%20AND%20SRC:MED&resulttype=core&format=json
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4 March 2020
author name string
Vikram Pattanayak
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2
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PMC publication ID
4851738
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26735016%20AND%20SRC:MED&resulttype=core&format=json
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4 March 2020
Michelle S Prew
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3
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4851738
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26735016%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 March 2020
Shengdar Q Tsai
series ordinal
4
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PMC publication ID
4851738
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26735016%20AND%20SRC:MED&resulttype=core&format=json
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4 March 2020
Nhu T Nguyen
series ordinal
5
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PMC publication ID
4851738
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4 March 2020
language of work or name
English
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publication date
6 January 2016
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4851738
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4 March 2020
published in
Nature
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PMC publication ID
4851738
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26735016%20AND%20SRC:MED&resulttype=core&format=json
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4 March 2020
volume
529
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4851738
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26735016%20AND%20SRC:MED&resulttype=core&format=json
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4 March 2020
issue
7587
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PMC publication ID
4851738
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26735016%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 March 2020
page(s)
490-495
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Europe PubMed Central
PMC publication ID
4851738
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26735016%20AND%20SRC:MED&resulttype=core&format=json
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4 March 2020
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Broadening the targeting range of Staphylococcus aureus CRISPR-Cas9 by modifying PAM recognition
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7 July 2018
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Dimeric CRISPR RNA-Guided FokI-dCas9 Nucleases Directed by Truncated gRNAs for Highly Specific Genome Editing
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GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases
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7 July 2018
Structural basis of PAM-dependent target DNA recognition by the Cas9 endonuclease
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7 July 2018
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7 July 2018
CRISPR/Cas9 systems have off-target activity with insertions or deletions between target DNA and guide RNA sequences
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7 July 2018
Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing
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7 July 2018
Fusion of catalytically inactive Cas9 to FokI nuclease improves the specificity of genome modification
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7 July 2018
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7 July 2018
Broad specificity profiling of TALENs results in engineered nucleases with improved DNA-cleavage specificity
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7 July 2018
Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA
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7 July 2018
Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation
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7 July 2018
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7 July 2018
Cas-OFFinder: a fast and versatile algorithm that searches for potential off-target sites of Cas9 RNA-guided endonucleases
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7 July 2018
Phylogeny of Cas9 determines functional exchangeability of dual-RNA and Cas9 among orthologous type II CRISPR-Cas systems
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7 July 2018
Analysis of off-target effects of CRISPR/Cas-derived RNA-guided endonucleases and nickases.
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7 July 2018
Orthogonal Cas9 proteins for RNA-guided gene regulation and editing
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7 July 2018
Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity
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7 July 2018
Efficient genome engineering in human pluripotent stem cells using Cas9 from Neisseria meningitidis
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7 July 2018
CRISPR/Cas9 systems targeting β-globin and CCR5 genes have substantial off-target activity
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7 July 2018
High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity
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7 July 2018
CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering
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7 July 2018
DNA targeting specificity of RNA-guided Cas9 nucleases
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7 July 2018
High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells
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7 July 2018
RNA-programmed genome editing in human cells
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PubMed Central
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7 July 2018
RNA-guided editing of bacterial genomes using CRISPR-Cas systems
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7 July 2018
RNA-guided human genome engineering via Cas9
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4851738
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7 July 2018
Multiplex genome engineering using CRISPR/Cas systems
1 reference
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reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4851738
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7 July 2018
A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity
1 reference
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reference URL
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7 July 2018
Geneious Basic: an integrated and extendable desktop software platform for the organization and analysis of sequence data
1 reference
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reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4851738
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7 July 2018
FLASH assembly of TALENs for high-throughput genome editing
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4851738
retrieved
7 July 2018
CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4851738
retrieved
7 July 2018
Identifiers
DOI
10.1038/NATURE16526
1 reference
stated in
Europe PubMed Central
PMC publication ID
4851738
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26735016%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 March 2020
Dimensions Publication ID
1010800066
0 references
PMC publication ID
4851738
1 reference
stated in
Europe PubMed Central
PMC publication ID
4851738
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26735016%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 March 2020
PubMed publication ID
26735016
1 reference
stated in
Europe PubMed Central
PMC publication ID
4851738
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26735016%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 March 2020
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