(Q34508486)

2 August 2017

Kynurenine-3-monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis (English)

1 reference

Kynurenine 3-monooxygenase

2 August 2017

1 reference

kynurenine metabolic process

GOA release 2020-03-11

1 reference

Kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author

Damian Mole

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26752518%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Scott P Webster

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26752518%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Olivier Mirguet

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26752518%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Natalie Z M Homer

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26752518%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Sarah Howie

24

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26752518%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

5

Margaret Binnie

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26752518%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

3

Iain Uings

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26752518%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

10

Benjamin Beaufils

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26752518%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

12

Lionel Trottet

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26752518%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

14

Christopher G Mowat

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26752518%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

25

Duncan S Holmes

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26752518%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

author name string

Xiaozhong Zheng

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26752518%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Jonathan P Hutchinson

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26752518%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Ann Walker

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26752518%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Nicolas Ancellin

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26752518%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Véronique Bénéton

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26752518%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Martin Wilkinson

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26752518%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Paul Rowland

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26752518%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Carl Haslam

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26752518%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Andrew McBride

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26752518%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

James E Baily

20

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26752518%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Matthew G F Sharp

21

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26752518%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

O James Garden

22

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26752518%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Jeremy Hughes

23

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26752518%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

John Liddle

26

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26752518%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

John P Iredale

27

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26752518%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Kris Wilson

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26752518%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

language of work or name

English

0 references

publication date

11 January 2016

1 reference

2 August 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26752518%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

volume

22

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26752518%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

issue

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26752518%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

page(s)

202-209

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26752518%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

10 June 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4871268/fullTextXML

inferred from PubMed Central ID database lookup

exact match

https://scigraph.springernature.com/pub.10.1038/nm.4020

0 references

cites work

Expression of the Kynurenine Pathway in Human Peripheral Blood Mononuclear Cells: Implications for Inflammatory and Neurodegenerative Disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4871268

Aryl hydrocarbon receptor control of a disease tolerance defence pathway

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4871268

Scavenging of reactive oxygen species by tryptophan metabolites helps Pseudomonas aeruginosa escape neutrophil killing.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4871268

Early organ dysfunction affects long-term survival in acute pancreatitis patients

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4871268

Lead discovery for human kynurenine 3-monooxygenase by high-throughput RapidFire mass spectrometry

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4871268

Activation of NAD(P)H oxidase by tryptophan-derived 3-hydroxykynurenine accelerates endothelial apoptosis and dysfunction in vivo.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4871268

Targeted Deletion of Kynurenine 3-Monooxygenase in Mice: A NEW TOOL FOR STUDYING KYNURENINE PATHWAY METABOLISM IN PERIPHERY AND BRAIN

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4871268

How good are my data and what is the resolution?

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4871268

Structural basis of kynurenine 3-monooxygenase inhibition

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4871268

IL-6 trans-signaling promotes pancreatitis-associated lung injury and lethality

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4871268

Kynurenines in the CNS: recent advances and new questions.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4871268

Kynurenic acid: a metabolite with multiple actions and multiple targets in brain and periphery

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4871268

Interleukin-1β: a new regulator of the kynurenine pathway affecting human hippocampal neurogenesis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4871268

An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4871268

Kynurenine 3-monooxygenase inhibition in blood ameliorates neurodegeneration

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4871268

Data processing and analysis with the autoPROC toolbox

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4871268

Overview of the CCP4 suite and current developments

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4871268

Aryl hydrocarbon receptor negatively regulates dendritic cell immunogenicity via a kynurenine-dependent mechanism

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4871268

An interaction between kynurenine and the aryl hydrocarbon receptor can generate regulatory T cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4871268

Features and development of Coot

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4871268

Kynurenine is an endothelium-derived relaxing factor produced during inflammation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4871268

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4871268

Incidence of individual organ dysfunction in fatal acute pancreatitis: analysis of 1024 death records

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4871268

The changing character of acute pancreatitis: epidemiology, etiology, and prognosis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4871268

Kerbs von Lungren 6 antigen is a marker of alveolar inflammation but not of infection in patients with acute respiratory distress syndrome

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4871268

A mouse model of acute biliary pancreatitis induced by retrograde pancreatic duct infusion of Na-taurocholate

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4871268

Nitric oxide is an important mediator of renal tubular epithelial cell death in vitro and in murine experimental hydronephrosis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4871268

Kynurenic acid as a ligand for orphan G protein-coupled receptor GPR35

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4871268

Protein production by auto-induction in high density shaking cultures

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4871268

Pancreatitis-associated acute lung injury: new insights

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4871268

Natural History of Organ Failure in Acute Pancreatitis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4871268

Hydrogen peroxide-mediated neuronal cell death induced by an endogenous neurotoxin, 3-hydroxykynurenine

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4871268

The effect of sodium salicylate on the binding of L-tryptophan to serum proteins

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4871268

The role of hydrogen peroxide in the in vitro cytotoxicity of 3-hydroxykynurenine

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4871268

Tryptophan catabolites in mesenteric lymph may contribute to pancreatitis-associated organ failure

7 July 2018

1 reference

KL-6 levels are elevated in plasma from patients with acute respiratory distress syndrome.

21 January 2018

1 reference

Increased plasma kynurenine values and kynurenine-tryptophan ratios after major trauma are early indicators for the development of sepsis

21 January 2018

1 reference

Kynurenine metabolism predicts cognitive function in patients following cardiac bypass and thoracic surgery.

21 January 2018

1 reference

The kynurenines are associated with oxidative stress, inflammation and the prevalence of cardiovascular disease in patients with end-stage renal disease

21 January 2018

1 reference

Electrochemical and in vitro evaluation of the redox-properties of kynurenine species

21 January 2018

1 reference

Species and cell types difference in tryptophan metabolism

21 January 2018

1 reference

FcepsilonRI induces the tryptophan degradation pathway involved in regulating T cell responses

21 January 2018

1 reference

Synthesis and release of neurotoxic kynurenine metabolites by human monocyte-derived macrophages

21 January 2018

1 reference

Differential preservation of lipopolysaccharide-induced chemokine/cytokine expression during experimental pancreatitis-associated organ failure in rats shows a regulatory expressed phenotype

21 January 2018

1 reference

The isolated perfused liver response to a 'second hit' of portal endotoxin during severe acute pancreatitis

21 January 2018

1 reference

FTY720-induced lymphocyte homing modulates post-transplant preservation/reperfusion injury

21 January 2018

1 reference

Enhanced enzymatic degradation of tryptophan by indoleamine 2,3-dioxygenase contributes to the tryptophan-deficient state seen after major trauma.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4871268

3-Hydroxykynurenine, an endogenous oxidative stress generator, causes neuronal cell death with apoptotic features and region selectivity.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4871268

3-Hydroxykynurenine toxicity on the rat striatum in vivo

27 October 2018

1 reference

12 December 2020

Development of a microplate fluorescence assay for kynurenine aminotransferase

1 reference

12 December 2020

Interleukin 10 prevents necrosis in murine experimental acute pancreatitis

1 reference

12 December 2020

A better model of acute pancreatitis for evaluating therapy

1 reference

12 December 2020

Identifiers

DOI

10.1038/NM.4020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26752518%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

10 June 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26752518%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

1 reference