(Q29306917)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24189070%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

title

Targeted deletion of kynurenine 3-monooxygenase in mice: a new tool for studying kynurenine pathway metabolism in periphery and brain (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24189070%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

6

1 reference

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29 February 2020

author name string

Flaviano Giorgini

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24189070%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

Shao-Yi Huang

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24189070%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

Korrapati V Sathyasaikumar

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24189070%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

Francesca M Notarangelo

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24189070%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

Marian A R Thomas

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24189070%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

Hui-Qiu Wu

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24189070%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

Robert Schwarcz

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24189070%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

Paul J Muchowski

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24189070%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

language of work or name

English

0 references

publication date

4 November 2013

2 references

9 April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24189070%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

29 February 2020

published in

2 references

9 April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24189070%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

volume

288

2 references

9 April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24189070%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

issue

51

2 references

9 April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24189070%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

page(s)

36554-36566

2 references

9 April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24189070%20AND%20SRC:MED&resulttype=core&format=json

Structural basis of kynurenine 3-monooxygenase inhibition

29 February 2020

cites work

1 reference

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Kynurenines in the mammalian brain: when physiology meets pathology

9 April 2017

1 reference

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An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor

9 April 2017

1 reference

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Downregulated kynurenine 3-monooxygenase gene expression and enzyme activity in schizophrenia and genetic association with schizophrenia endophenotypes

9 April 2017

1 reference

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Kynurenine 3-monooxygenase polymorphisms: relevance for kynurenic acid synthesis in patients with schizophrenia and healthy controls

9 April 2017

1 reference

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The kynurenine pathway modulates neurodegeneration in a Drosophila model of Huntington's disease

9 April 2017

1 reference

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The indoleamine-2,3-dioxygenase (IDO) inhibitor 1-methyl-D-tryptophan upregulates IDO1 in human cancer cells

9 April 2017

1 reference

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Aryl hydrocarbon receptor negatively regulates dendritic cell immunogenicity via a kynurenine-dependent mechanism

9 April 2017

1 reference

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Targeting kynurenine 3-monooxygenase (KMO): implications for therapy in Huntington's disease

9 April 2017

1 reference

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Kynurenine is an endothelium-derived relaxing factor produced during inflammation

9 April 2017

1 reference

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The kynurenic acid hypothesis of schizophrenia

9 April 2017

1 reference

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Kynurenic acid as a ligand for orphan G protein-coupled receptor GPR35

9 April 2017

1 reference

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Elevated brain 3-hydroxykynurenine and quinolinate levels in Huntington disease mice

9 April 2017

1 reference

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A genomic screen in yeast implicates kynurenine 3-monooxygenase as a therapeutic target for Huntington disease

9 April 2017

1 reference

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The brain metabolite kynurenic acid inhibits alpha7 nicotinic receptor activity and increases non-alpha7 nicotinic receptor expression: physiopathological implications

9 April 2017

1 reference

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Changes in kynurenic, anthranilic, and quinolinic acid concentrations in rat brain tissue during development

9 April 2017

1 reference

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Human microglia convert l-tryptophan into the neurotoxin quinolinic acid

9 April 2017

1 reference

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Quinolinic acid: a potent endogenous excitant at amino acid receptors in CNS

9 April 2017

1 reference

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Synthesis of quinolinic acid by 3-hydroxyanthranilic acid oxygenase in rat brain tissue in vitro

9 April 2017

1 reference

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Quinolinic acid is a potent lipid peroxidant in rat brain homogenates

9 April 2017

1 reference

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High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP

9 April 2017

1 reference

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An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination

9 April 2017

1 reference

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Kynurenines in the CNS: recent advances and new questions.

9 April 2017

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3-Hydroxykynurenine: an intriguing molecule exerting dual actions in the central nervous system

3 June 2018

1 reference

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An expanding range of targets for kynurenine metabolites of tryptophan

3 June 2018

1 reference

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Gas chromatography/tandem mass spectrometry detection of extracellular kynurenine and related metabolites in normal and lesioned rat brain

3 June 2018

1 reference

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Kynurenic acid: a metabolite with multiple actions and multiple targets in brain and periphery

3 June 2018

1 reference

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Kynurenine pathway metabolites in humans: disease and healthy States

3 June 2018

1 reference

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The kynurenine system and immunoregulation

3 June 2018

1 reference

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Involvement of kynurenines in Huntington's disease and stroke-induced brain damage

3 June 2018

1 reference

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Kynurenine 3-monooxygenase inhibition in blood ameliorates neurodegeneration

3 June 2018

1 reference

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Kynurenines and intestinal neurotransmission: the role of N-methyl-D-aspartate receptors.

3 June 2018

1 reference

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Indoleamine 2,3-dioxygenase as a modifier of pathogenic inflammation in cancer and other inflammation-associated diseases

3 June 2018

1 reference

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Impaired kynurenine pathway metabolism in the prefrontal cortex of individuals with schizophrenia

3 June 2018

1 reference

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Interferon-gamma-inducible kynurenines/pteridines inflammation cascade: implications for aging and aging-associated psychiatric and medical disorders

3 June 2018

1 reference

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An interaction between kynurenine and the aryl hydrocarbon receptor can generate regulatory T cells

3 June 2018

1 reference

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Cortical kynurenine pathway metabolism: a novel target for cognitive enhancement in Schizophrenia

3 June 2018

1 reference

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Kynurenic acid is a potent endogenous aryl hydrocarbon receptor ligand that synergistically induces interleukin-6 in the presence of inflammatory signaling

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3868768

On the relationship between the two branches of the kynurenine pathway in the rat brain in vivo

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3868768

Prolonged kynurenine 3-hydroxylase inhibition reduces development of levodopa-induced dyskinesias in parkinsonian monkeys

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3868768

NAD+ metabolism in health and disease

3 June 2018

1 reference

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Schizophrenia as an inflammation-mediated dysbalance of glutamatergic neurotransmission

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3868768

Elevations of endogenous kynurenic acid produce spatial working memory deficits

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3868768

Nanomolar concentrations of kynurenic acid reduce extracellular dopamine levels in the striatum

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3868768

Increased cortical kynurenate content in schizophrenia

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3868768

3-Hydroxyanthranilic acid, an L-tryptophan metabolite, induces apoptosis in monocyte-derived cells stimulated by interferon-gamma

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3868768

Synthesis and biochemical evaluation of N-(4-phenylthiazol-2-yl)benzenesulfonamides as high-affinity inhibitors of kynurenine 3-hydroxylase.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3868768

(R,S)-3,4-dichlorobenzoylalanine (FCE 28833A) causes a large and persistent increase in brain kynurenic acid levels in rats.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3868768

Metal-mediated oxidative damage to cellular and isolated DNA by certain tryptophan metabolites.

3 June 2018

1 reference

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Quantitative aspects of tryptophan metabolism in humans and other species: a review

3 June 2018

1 reference

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A glycine site associated with N-methyl-D-aspartic acid receptors: characterization and identification of a new class of antagonists

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3868768

Presence of 3-hydroxyanthranilic acid in rat tissues and evidence for its production from anthranilic acid in the brain.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3868768

Human macrophages convert L-tryptophan into the neurotoxin quinolinic acid

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3868768

Inter-relationships between quinolinic acid, neuroactive kynurenines, neopterin and beta 2-microglobulin in cerebrospinal fluid and serum of HIV-1-infected patients

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3868768

Kynurenine pathway metabolism in human astrocytes: a paradox for neuronal protection

3 June 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.503813

Histone deacetylase inhibition modulates kynurenine pathway activation in yeast, microglia, and mice expressing a mutant huntingtin fragment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.503813

Induction of indolamine 2,3-dioxygenase and kynurenine 3-monooxygenase in rat brain following a systemic inflammatory challenge: a role for IFN-gamma?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.503813

On the antioxidant properties of kynurenic acid: free radical scavenging activity and inhibition of oxidative stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.503813

Kynurenic acid blocks neurotoxicity and seizures induced in rats by the related brain metabolite quinolinic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.503813

Inhibitors of kynurenine hydroxylase and kynureninase increase cerebral formation of kynurenate and have sedative and anticonvulsant activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.503813

Quinolinic acid phosphoribosyltransferase in rat brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.503813

Establishment of true niacin deficiency in quinolinic acid phosphoribosyltransferase knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.503813

Kynurenic acid protects against the homocysteine-induced impairment of endothelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.503813

Micromolar Brain Levels of Kynurenic Acid are Associated with a Disruption of Auditory Sensory Gating in the Rat

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.503813

Endogenous kynurenic acid disrupts prepulse inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.503813

L-kynurenine treatment alters contextual fear conditioning and context discrimination but not cue-specific fear conditioning.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.503813

Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.503813

Kynurenine hydroxylase inhibitors reduce ischemic brain damage: studies with (m-nitrobenzoyl)-alanine (mNBA) and 3,4-dimethoxy-[-N-4-(nitrophenyl)thiazol-2yl]-benzenesulfonamide (Ro 61-8048) in models of focal or global brain ischemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.503813

Alterations in kynurenine precursor and product levels in schizophrenia and bipolar disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.503813

Neostriatal and cortical quinolinate levels are increased in early grade Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.503813

The excitatory amino acid antagonist kynurenic acid administered after hypoxic-ischemia in neonatal rats offers neuroprotection

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.503813

Analysis of Fgf8 gene function in vertebrate development

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3868768

Formation of hydroxanthommatin-derived radical in the oxidation of 3-hydroxykynurenine

26 November 2018

1 reference

12 December 2020

New promises for manipulation of kynurenine pathway in cancer and neurological diseases

1 reference

12 December 2020

Regulation of the kynurenine pathway by IFN-gamma in murine cloned macrophages and microglial cells

1 reference

12 December 2020

The niacin required for optimum growth can be synthesized from L-tryptophan in growing mice lacking tryptophan-2,3-dioxygenase

1 reference

12 December 2020

Quantification of 3-hydroxykynurenine in brain by high-performance liquid chromatography and electrochemical detection

1 reference

12 December 2020

The intermediary metabolism of tryptophan by cat and rat tissue preparations

1 reference

12 December 2020

Antibodies to quinolinic acid and the determination of its cellular distribution within the rat immune system

1 reference

12 December 2020

Comparison of the neurochemical and behavioral effects resulting from the inhibition of kynurenine hydroxylase and/or kynureninase

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M113.503813

3 references

9 April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24189070%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24189070%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

PubMed publication ID

24189070

2 references