(Q37892975)

24 August 2017

1 reference

title

Involvement of kynurenines in Huntington's disease and stroke-induced brain damage (English)

1 reference

24 August 2017

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Trevor W Stone

1

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author name string

Caroline M Forrest

series ordinal

2

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24 August 2017

Nicholas Stoy

series ordinal

3

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24 August 2017

L Gail Darlington

series ordinal

4

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24 August 2017

language of work or name

1 reference

22 June 2011

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Journal of Neural Transmission

24 August 2017

published in

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24 August 2017

volume

119

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24 August 2017

issue

2

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24 August 2017

page(s)

261-274

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Monitoring of immune activation using biochemical changes in a porcine model of cardiac arrest

24 August 2017

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Selective putaminal excitotoxic lesions in non-human primates model the movement disorder of Huntington disease.

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Prolonged survival of a murine model of cerebral malaria by kynurenine pathway inhibition

21 January 2018

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Nicotinylalanine increases cerebral kynurenic acid content and has anticonvulsant activity

21 January 2018

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Polyglutamine-modulated striatal calpain activity in YAC transgenic huntington disease mouse model: impact on NMDA receptor function and toxicity

21 January 2018

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Kynurenine hydroxylase inhibitors reduce ischemic brain damage: studies with (m-nitrobenzoyl)-alanine (mNBA) and 3,4-dimethoxy-[-N-4-(nitrophenyl)thiazol-2yl]-benzenesulfonamide (Ro 61-8048) in models of focal or global brain ischemia

21 January 2018

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Altered kynurenine metabolism correlates with infarct volume in stroke

21 January 2018

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The role of hydrogen peroxide in the in vitro cytotoxicity of 3-hydroxykynurenine

21 January 2018

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HLA-G expression defines a novel regulatory T-cell subset present in human peripheral blood and sites of inflammation.

21 January 2018

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Tryptophan loading induces oxidative stress

21 January 2018

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Blood levels of kynurenines, interleukin-23 and soluble human leucocyte antigen-G at different stages of Huntington's disease

21 January 2018

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Genomewide linkage scan reveals novel loci modifying age of onset of Huntington's disease in the Venezuelan HD kindreds

21 January 2018

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Reactive microglia in cerebral ischaemia: an early mediator of tissue damage?

21 January 2018

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Electrochemical and in vitro evaluation of the redox-properties of kynurenine species

21 January 2018

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A genomic screen in yeast implicates kynurenine 3-monooxygenase as a therapeutic target for Huntington disease

21 January 2018

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Histone deacetylase inhibition modulates kynurenine pathway activation in yeast, microglia, and mice expressing a mutant huntingtin fragment.

21 January 2018

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3-Hydroxykynurenine and 3-Hydroxyanthranilic Acid Generate Hydrogen Peroxide and Promote α-Crystallin Cross-Linking by Metal Ion Reduction†

21 January 2018

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Linking two immuno-suppressive molecules: indoleamine 2,3 dioxygenase can modify HLA-G cell-surface expression.

21 January 2018

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Early kynurenergic impairment in Huntington's disease and in a transgenic animal model

21 January 2018

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Neostriatal and cortical quinolinate levels are increased in early grade Huntington's disease

21 January 2018

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Elevated brain 3-hydroxykynurenine and quinolinate levels in Huntington disease mice

21 January 2018

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Characterization of the kynurenine pathway in human neurons

21 January 2018

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Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

21 January 2018

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Modulation of striatal quinolinate neurotoxicity by elevation of endogenous brain kynurenic acid

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00702-011-0676-8

Glutamate uptake is reduced in prefrontal cortex in Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-011-0676-8

In vivo evidence for NMDA receptor-mediated excitotoxicity in a murine genetic model of Huntington disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-011-0676-8

Quinolinic acid and inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-011-0676-8

Quinolinic acid and kynurenine pathway metabolism in inflammatory and non-inflammatory neurological disease

21 January 2018

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Human macrophages convert L-tryptophan into the neurotoxin quinolinic acid

21 January 2018

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Human microglia convert l-tryptophan into the neurotoxin quinolinic acid

21 January 2018

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Quinolinic acid-induced increases in calbindin D28k immunoreactivity in rat striatal neurons in vivo and in vitro mimic the pattern seen in Huntington's disease

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00702-011-0676-8

Inflammation in stroke and focal cerebral ischemia.

21 January 2018

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Administration of recombinant human Activin-A has powerful neurotrophic effects on select striatal phenotypes in the quinolinic acid lesion model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-011-0676-8

HLA-G: a human pregnancy-related immunomodulator

21 January 2018

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Dysfunction of brain kynurenic acid metabolism in Huntington's disease: focus on kynurenine aminotransferases

21 January 2018

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Soluble HLA-G influences the release of cytokines from allogeneic peripheral blood mononuclear cells in culture

21 January 2018

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21 January 2018

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Indoleamine 2,3 dioxygenase and human leucocyte antigen-G inhibit the T-cell alloproliferative response through two independent pathways

21 January 2018

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Activated immune system in patients with Huntington's disease

21 January 2018

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Tryptophan metabolite 3-hydroxyanthranilic acid selectively induces activated T cell death via intracellular GSH depletion

21 January 2018

1 reference

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In vitro evidence for an antioxidant role of 3-hydroxykynurenine and 3-hydroxyanthranilic acid in the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-011-0676-8

Regulatory role of tryptophan degradation pathway in HLA-G expression by human monocyte-derived dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-011-0676-8

Effect of 3-hydroxyanthranilic acid in the immunosuppressive molecules indoleamine dioxygenase and HLA-G in macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-011-0676-8

Tryptophan metabolism and oxidative stress in patients with chronic brain injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-011-0676-8

Inflammatory response after acute ischemic stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-011-0676-8

Gut CD103+ dendritic cells express indoleamine 2,3-dioxygenase which influences T regulatory/T effector cell balance and oral tolerance induction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-011-0676-8

An interaction between kynurenine and the aryl hydrocarbon receptor can generate regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-011-0676-8

Up-regulation of GLT1 expression increases glutamate uptake and attenuates the Huntington's disease phenotype in the R6/2 mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-011-0676-8

Tryptophan metabolism and brain function: focus on kynurenine and other indole metabolites

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-011-0676-8

Prevention of allogeneic fetal rejection by tryptophan catabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-011-0676-8

Anti-infectious activity of tryptophan metabolites in the L-tryptophan-L-kynurenine pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-011-0676-8

Role of kynurenines in the central and peripheral nervous systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-011-0676-8

Hydrogen peroxide-mediated neuronal cell death induced by an endogenous neurotoxin, 3-hydroxykynurenine

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-011-0676-8

Increased brain concentrations of a neurotoxin, 3-hydroxykynurenine, in Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-011-0676-8

Targeting oxidative/nitrergic stress ameliorates motor impairment, and attenuates synaptic mitochondrial dysfunction and lipid peroxidation in two models of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-011-0676-8

An iontophoretic investigation of the actions of convulsant kynurenines and their interaction with the endogenous excitant quinolinic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-011-0676-8

Indoleamine 2,3-dioxygenase activity in nonagenarians is markedly increased and predicts mortality

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-011-0676-8

Behavioral and electrophysiological correlates of the quinolinic acid rat model of Huntington's disease in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-011-0676-8

Increased brain 3-hydroxykynurenine in Huntington's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-011-0676-8

Kynurenine pathway inhibition reduces central nervous system inflammation in a model of human African trypanosomiasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-011-0676-8

Synthesis and biochemical evaluation of N-(4-phenylthiazol-2-yl)benzenesulfonamides as high-affinity inhibitors of kynurenine 3-hydroxylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-011-0676-8

Pathophysiology of Huntington's disease: from huntingtin functions to potential treatments

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-011-0676-8

Effects of immune activation on quinolinic acid and neuroactive kynurenines in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-011-0676-8

Mechanism of delayed increases in kynurenine pathway metabolism in damaged brain regions following transient cerebral ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-011-0676-8

Early and progressive accumulation of reactive microglia in the Huntington disease brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-011-0676-8

Transgenic models of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-011-0676-8

Quinolinic acid: an endogenous metabolite that produces axon-sparing lesions in rat brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-011-0676-8

3-Hydroxyanthranilate oxygenase activity is increased in the brains of Huntington disease victims

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-011-0676-8

Manipulation of brain kynurenines: glial targets, neuronal effects, and clinical opportunities

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-011-0676-8

Of mice, rats and men: Revisiting the quinolinic acid hypothesis of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-011-0676-8

Abnormalities of somatosensory evoked potentials in the quinolinic acid model of Huntington's disease: evidence that basal ganglia modulate sensory cortical input

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-011-0676-8

Endogenous kynurenines as targets for drug discovery and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-011-0676-8

Quinolinic acid: a potent endogenous excitant at amino acid receptors in CNS

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-011-0676-8

Kynurenines in the CNS: from endogenous obscurity to therapeutic importance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-011-0676-8

Kynurenic acid blocks nicotinic synaptic transmission to hippocampal interneurons in young rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-011-0676-8

Tryptophan metabolism and oxidative stress in patients with Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-011-0676-8

Inhibition of allogeneic T cell proliferation by indoleamine 2,3-dioxygenase-expressing dendritic cells: mediation of suppression by tryptophan metabolites

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-011-0676-8

Polyglutamine disruption of the huntingtin exon 1 N terminus triggers a complex aggregation mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-011-0676-8

Redox reactions related to indoleamine 2,3-dioxygenase and tryptophan metabolism along the kynurenine pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-011-0676-8

Impaired synaptic plasticity in mice carrying the Huntington's disease mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-011-0676-8

Comparative behavioral and neurochemical studies with striatal kainic acid- or quinolinic acid-lesioned rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-011-0676-8

Inflammation in adult and neonatal stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-011-0676-8

Differential effects of the tryptophan metabolite 3-hydroxyanthranilic acid on the proliferation of human CD8+ T cells induced by TCR triggering or homeostatic cytokines

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-011-0676-8

Parallel induction of tetrahydrobiopterin biosynthesis and indoleamine 2,3-dioxygenase activity in human cells and cell lines by interferon-gamma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-011-0676-8

Brain ischemia and reperfusion: molecular mechanisms of neuronal injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-011-0676-8

Interferon-gamma-induced tryptophan degradation: neuropsychiatric and immunological consequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-011-0676-8

Expression of the immune-tolerogenic major histocompatibility molecule HLA-G in multiple sclerosis: implications for CNS immunity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-011-0676-8

HLA-G in the nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-011-0676-8

Interferon-gamma-induced conversion of tryptophan: immunologic and neuropsychiatric aspects

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-011-0676-8

Immune activation and degradation of tryptophan in coronary heart disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-011-0676-8

IDO: a double-edged sword for T(H)1/T(H)2 regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-011-0676-8

IDO upregulates regulatory T cells via tryptophan catabolite and suppresses encephalitogenic T cell responses in experimental autoimmune encephalomyelitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-011-0676-8

A potent small molecule inhibits polyglutamine aggregation in Huntington's disease neurons and suppresses neurodegeneration in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-011-0676-8

Unified Huntington's disease rating scale: Reliability and consistency

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-011-0676-8

KYNURENINE PATHWAY METABOLISM IN PATIENTS WITH OSTEOPOROSIS AFTER 2 YEARS OF DRUG TREATMENT

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-011-0676-8

Activated human microglia produce the excitotoxin quinolinic acid

21 January 2018

1 reference

12 December 2020

The brain metabolite kynurenic acid inhibits alpha7 nicotinic receptor activity and increases non-alpha7 nicotinic receptor expression: physiopathological implications

1 reference

12 December 2020

Temporal and spatial changes of quinolinic acid immunoreactivity in the immune system of lipopolysaccharide-stimulated mice

1 reference

12 December 2020

Dysfunctional kynurenine pathway metabolism in the R6/2 mouse model of Huntington's disease

1 reference

12 December 2020

Effects of striatal excitotoxicity on huntingtin-like immunoreactivity

1 reference

12 December 2020

Human macrophages degrade tryptophan upon induction by interferon-gamma

1 reference

12 December 2020

3-Hydroxykynurenine toxicity on the rat striatum in vivo

1 reference

12 December 2020

Mitochondrial dysfunction and free radical damage in the Huntington R6/2 transgenic mouse.

1 reference

12 December 2020

Functional gene expression profiling in yeast implicates translational dysfunction in mutant huntingtin toxicity.

1 reference

12 December 2020

An investigation of the activities of 3-hydroxykynureninase and kynurenine aminotransferase in the brain in Huntington's disease

1 reference

12 December 2020

Movement disorder following excitotoxin lesions in primates

1 reference

12 December 2020

Oxidative stress in Huntington's disease

1 reference

12 December 2020

3-Hydroxykynurenine, an endogenous oxidative stress generator, causes neuronal cell death with apoptotic features and region selectivity

1 reference

12 December 2020

Neurochemical characterization of excitotoxin lesions in the cerebral cortex

1 reference

12 December 2020

3-Hydroxykynurenine potentiates quinolinate but not NMDA toxicity in the rat striatum

1 reference

12 December 2020

Cytotoxicity of 3-hydroxykynurenine in a neuronal hybrid cell line

1 reference

12 December 2020

Development of selective immune tolerance towards the allogeneic fetus during pregnancy: Role of tryptophan catabolites (Review).

1 reference

12 December 2020

Neuropharmacology of quinolinic and kynurenic acids

1 reference

12 December 2020

Intrathecal synthesis of soluble HLA-G and HLA-I molecules are reciprocally associated to clinical and MRI activity in patients with multiple sclerosis.

1 reference

12 December 2020

Huntington aggregates may not predict neuronal death in Huntington's disease

1 reference

12 December 2020

On the Biological Importance of the 3-hydroxyanthranilic Acid: Anthranilic Acid Ratio.

1 reference

12 December 2020

Kynurenine pathway enzymes in brain: responses to ischemic brain injury versus systemic immune activation

1 reference

12 December 2020

Oxidative reactivity of the tryptophan metabolites 3-hydroxyanthranilate, cinnabarinate, quinolinate and picolinate

1 reference

12 December 2020

Chronic quinolinic acid lesions in rats closely resemble Huntington's disease

1 reference

12 December 2020

Clinical experiences with the use of indole-3-pyruvic acid.

1 reference

12 December 2020

Decreased serum tryptophan in patients with HIV-1 infection correlates with increased serum neopterin and with neurologic/psychiatric symptoms

1 reference

12 December 2020

3-Hydroxyanthranilic acid is an efficient, cell-derived co-antioxidant for alpha-tocopherol, inhibiting human low density lipoprotein and plasma lipid peroxidation

1 reference

12 December 2020

Characterization of progressive motor deficits in mice transgenic for the human Huntington's disease mutation.

1 reference

12 December 2020

10.1007/S00702-011-0676-8

Identifiers

DOI

1 reference

24 August 2017

1 reference