(Q45291700)

English

Polyglutamine-modulated striatal calpain activity in YAC transgenic huntington disease mouse model: impact on NMDA receptor function and toxicity

scientific article published in November 2008

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scholarly article

1 reference

Europe PubMed Central

11 December 2017

Polyglutamine-modulated striatal calpain activity in YAC transgenic huntington disease mouse model: impact on NMDA receptor function and toxicity (English)

1 reference

Europe PubMed Central

11 December 2017

Huntington's disease

0 references

1 reference

based on heuristic

inferred from title

Michael R. Hayden

7

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6671821&resulttype=core&format=json

16 May 2020

8

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6671821&resulttype=core&format=json

16 May 2020

author name string

Catherine M Cowan

1

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6671821&resulttype=core&format=json

16 May 2020

Mannie M Y Fan

2

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6671821&resulttype=core&format=json

16 May 2020

Jing Fan

3

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6671821&resulttype=core&format=json

16 May 2020

Jacqueline Shehadeh

4

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6671821&resulttype=core&format=json

16 May 2020

Lily Y J Zhang

5

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6671821&resulttype=core&format=json

16 May 2020

Rona K Graham

6

1 reference

Europe PubMed Central

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16 May 2020

language of work or name

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publication date

1 November 2008

1 reference

Europe PubMed Central

11 December 2017

Journal of Neuroscience

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6671821&resulttype=core&format=json

16 May 2020

28

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6671821&resulttype=core&format=json

16 May 2020

48

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6671821&resulttype=core&format=json

16 May 2020

12725-12735

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6671821&resulttype=core&format=json

16 May 2020

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6671821/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

The glutamate receptor ion channels

1 reference

https://pubmed.ncbi.nlm.nih.gov/19036965

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19036965

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Translational suppression of calpain blocks long-term potentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19036965

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Declines in mRNA expression of different subunits may account for differential effects of aging on agonist and antagonist binding to the NMDA receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/19036965

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synergistic activation of caspase-3 by m-calpain after neonatal hypoxia-ischemia: a mechanism of "pathological apoptosis"?

1 reference

https://pubmed.ncbi.nlm.nih.gov/19036965

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular determinants of NMDA receptor internalization

1 reference

https://pubmed.ncbi.nlm.nih.gov/19036965

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Specific proteolysis of the NR2 subunit at multiple sites by calpain

1 reference

https://pubmed.ncbi.nlm.nih.gov/19036965

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased sensitivity to N-methyl-D-aspartate receptor-mediated excitotoxicity in a mouse model of Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19036965

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calpain activation in Huntington's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19036965

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calpain-dependent cleavage of cain/cabin1 activates calcineurin to mediate calcium-triggered cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/19036965

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteolysis of the N-methyl-d-aspartate receptor by calpain in situ

1 reference

https://pubmed.ncbi.nlm.nih.gov/19036965

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Yin and Yang of NMDA receptor signalling

1 reference

https://pubmed.ncbi.nlm.nih.gov/19036965

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19036965

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calpain is a major cell death effector in selective striatal degeneration induced in vivo by 3-nitropropionate: implications for Huntington's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19036965

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteolytic Mechanism for the Neurodegeneration of Alzheimer's Disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19036965

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Critical role of calpain-mediated cleavage of calcineurin in excitotoxic neurodegeneration.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19036965

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of NR2B-type NMDA receptors in selective neurodegeneration in Huntington disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19036965

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective activation induced cleavage of the NR2B subunit by calpain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19036965

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of calpain cleavage of huntingtin reduces toxicity: accumulation of calpain/caspase fragments in the nucleus

1 reference

https://pubmed.ncbi.nlm.nih.gov/19036965

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potentiation of NMDA receptor-mediated excitotoxicity linked with intrinsic apoptotic pathway in YAC transgenic mouse model of Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19036965

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endocytosis and degradative sorting of NMDA receptors by conserved membrane-proximal signals.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19036965

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interactions of postsynaptic density-95 and the NMDA receptor 2 subunit control calpain-mediated cleavage of the NMDA receptor.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19036965

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteolysis of NR2B by calpain in the hippocampus of epileptic rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19036965

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of N-methyl-D-aspartate receptors by calpain in cortical neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/19036965

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cognitive dysfunction precedes neuropathology and motor abnormalities in the YAC128 mouse model of Huntington's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19036965

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteolysis of neuronal cytoskeletal proteins by calpain contributes to rat retinal cell death induced by hypoxia

1 reference

https://pubmed.ncbi.nlm.nih.gov/19036965

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Spectrin and calpain: a 'target' and a 'sniper' in the pathology of neuronal cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19036965

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Absence of behavioral abnormalities and neurodegeneration in vivo despite widespread neuronal huntingtin inclusions

1 reference

https://pubmed.ncbi.nlm.nih.gov/19036965

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The synaptic localization of NR2B-containing NMDA receptors is controlled by interactions with PDZ proteins and AP-2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19036965

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Striatal neuronal apoptosis is preferentially enhanced by NMDA receptor activation in YAC transgenic mouse model of Huntington disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19036965

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Levels of mutant huntingtin influence the phenotypic severity of Huntington disease in YAC128 mouse models

1 reference

https://pubmed.ncbi.nlm.nih.gov/19036965

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caspase and calpain function in cell death: bridging the gap between apoptosis and necrosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19036965

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wild-type huntingtin protects neurons from excitotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/19036965

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ubiquitous calpains promote both apoptosis and survival signals in response to different cell death stimuli.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19036965

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BCL2 family in DNA damage and cell cycle control

1 reference

https://pubmed.ncbi.nlm.nih.gov/19036965

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin

1 reference

https://pubmed.ncbi.nlm.nih.gov/19036965

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calpain product of WT-CRMP2 reduces the amount of surface NR2B NMDA receptor subunit.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19036965

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abnormalities of striatal projection neurons and N-methyl-D-aspartate receptors in presymptomatic Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19036965

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective neuronal degeneration in Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19036965

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altered NMDA receptor trafficking in a yeast artificial chromosome transgenic mouse model of Huntington's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19036965

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fyn-mediated phosphorylation of NR2B Tyr-1336 controls calpain-mediated NR2B cleavage in neurons and heterologous systems

1 reference

https://pubmed.ncbi.nlm.nih.gov/19036965

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The dichotomy of NMDA receptor signaling.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19036965

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial sensitivity and altered calcium handling underlie enhanced NMDA-induced apoptosis in YAC128 model of Huntington's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19036965

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Postsynaptic density-95 (PSD-95) and calcineurin control the sensitivity of N-methyl-D-aspartate receptors to calpain cleavage in cortical neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/19036965

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Replication of the neurochemical characteristics of Huntington's disease by quinolinic acid

1 reference

https://pubmed.ncbi.nlm.nih.gov/19036965

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The quinolinic acid model of Huntington's disease: locomotor abnormalities

1 reference

https://pubmed.ncbi.nlm.nih.gov/19036965

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NMDA receptor losses in putamen from patients with Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19036965

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Developmental and regional expression in the rat brain and functional properties of four NMDA receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/19036965

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95

1 reference

https://pubmed.ncbi.nlm.nih.gov/19036965

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calcium-activated neutral proteinase (calpain) system in aging and Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19036965

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunolocalization of calpain I-mediated spectrin degradation to vulnerable neurons in the ischemic gerbil brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19036965

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19036965

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Widespread activation of calcium-activated neutral proteinase (calpain) in the brain in Alzheimer disease: a potential molecular basis for neuronal degeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/19036965

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract

1 reference

https://pubmed.ncbi.nlm.nih.gov/19036965

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synaptic targeting of glutamate receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/19036965

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NMDA receptor heterogeneity during postnatal development of the rat brain: differential expression of the NR2A, NR2B, and NR2C subunit proteins.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19036965

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Of molecular interactions, mice and mechanisms: new insights into Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19036965

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calpain I activation in rat hippocampal neurons in culture is NMDA receptor selective and not essential for excitotoxic cell death.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19036965

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calpain-mediated regulation of NMDA receptor structure and function

1 reference

https://pubmed.ncbi.nlm.nih.gov/19036965

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Huntington disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19036965

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation regulates calpain-mediated truncation of glutamate ionotropic receptors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19036965

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.4619-08.2008

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6671821&resulttype=core&format=json

16 May 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6671821&resulttype=core&format=json

16 May 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6671821&resulttype=core&format=json

16 May 2020

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