(Q34509815)

2 August 2017

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title

Potential treatment opportunities for Alzheimer's disease through inhibition of secretases and Abeta immunization (English)

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2 August 2017

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Schenk D

1

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2 August 2017

Games D

series ordinal

2

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2 August 2017

Seubert P

series ordinal

3

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2 August 2017

language of work or name

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1 October 2001

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Journal of Molecular Neuroscience

2 August 2017

published in

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2 August 2017

volume

17

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2 August 2017

issue

2

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2 August 2017

page(s)

259-267

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https://scigraph.springernature.com/pub.10.1385/jmn:17:2:259

2 August 2017

exact match

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cites work

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

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12 December 2020

Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene

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12 December 2020

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

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Purification and cloning of amyloid precursor protein beta-secretase from human brain

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Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

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12 December 2020

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

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The genetics and molecular pathology of Alzheimer's disease: roles of amyloid and the presenilins

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12 December 2020

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Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

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Alzheimer's disease: neurodevelopment converges with neurodegeneration

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Zinc-induced Alzheimer's Abeta1-40 aggregation is mediated by conformational factors.

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12 December 2020

Monoclonal antibodies inhibit in vitro fibrillar aggregation of the Alzheimer beta-amyloid peptide

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12 December 2020

Beta-amyloid precursor protein cleavage by a membrane-bound protease

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12 December 2020

Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

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12 December 2020

A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid

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Characterization of pathology in transgenic mice over-expressing human genomic and cDNA tau transgenes

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Mild cognitive impairment: clinical characterization and outcome

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Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

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Are presenilins intramembrane-cleaving proteases? Implications for the molecular mechanism of Alzheimer's disease

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Cleavage of amyloid beta peptide during constitutive processing of its precursor

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Cholinesterase inhibitors stabilize Alzheimer disease

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Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

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12 December 2020

beta-peptide immunization: a possible new treatment for Alzheimer disease

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12 December 2020

Beta-secretase processing of the beta-amyloid precursor protein in transgenic mice is efficient in neurons but inefficient in astrocytes

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12 December 2020

A common enzyme connects notch signaling and Alzheimer's disease

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12 December 2020

A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling

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12 December 2020

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

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12 December 2020

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Frontotemporal lobar degeneration. An update on clinical, pathological and genetic findings

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12 December 2020

Function and dysfunction of the presenilins

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12 December 2020

Alzheimer disease: the new agenda

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12 December 2020

Treatment of Alzheimer's disease: rationale and strategies

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12 December 2020

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12 December 2020

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12 December 2020

Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

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12 December 2020

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12 December 2020

BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics

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12 December 2020

Inhibition of beta-amyloid formation identifies proteolytic precursors and subcellular site of catabolism

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Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43).

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A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease

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12 December 2020

Separation of presenilin function in amyloid beta-peptide generation and endoproteolysis of Notch

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12 December 2020

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12 December 2020

Trials to slow progression and prevent disease onset.

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12 December 2020

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12 December 2020

A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease

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12 December 2020

The E280A presenilin 1 Alzheimer mutation produces increased A beta 42 deposition and severe cerebellar pathology.

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12 December 2020

Comparison of neurodegenerative pathology in transgenic mice overexpressing V717F beta-amyloid precursor protein and Alzheimer's disease

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12 December 2020

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12 December 2020

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12 December 2020

New insights into the genetics of Alzheimer's disease

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

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12 December 2020

Identifiers

DOI

10.1385/JMN:17:2:259

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Dimensions Publication ID

2 August 2017

1032465639

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