(Q34535890)

2 August 2017

title

Evidence from solid-state NMR for nonhelical conformations in the transmembrane domain of the amyloid precursor protein (English)

1 reference

2 August 2017

main subject

transmembrane protein

0 references

3

Robert Tycko

1 reference

2 August 2017

Jun-Xia Lu

1

1 reference

2 August 2017

Wai-Ming Yau

series ordinal

2

1 reference

2 August 2017

language of work or name

English

0 references

publication date

1 February 2011

1 reference

2 August 2017

1 reference

2 August 2017

volume

100

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2 August 2017

issue

3

1 reference

2 August 2017

page(s)

711-719

1 reference

Oligomerization state and supramolecular structure of the HIV‐1 Vpu protein transmembrane segment in phospholipid bilayers

2 August 2017

cites work

1 reference

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Structures of beta-amyloid peptide 1-40, 1-42, and 1-55-the 672-726 fragment of APP-in a membrane environment with implications for interactions with gamma-secretase

7 July 2018

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The structure and function of Alzheimer's gamma secretase enzyme complex.

7 July 2018

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Induced dimerization of the amyloid precursor protein leads to decreased amyloid-beta protein production

7 July 2018

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Transmembrane structures of amyloid precursor protein dimer predicted by replica-exchange molecular dynamics simulations

7 July 2018

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Cholesterol in Alzheimer's disease: unresolved questions.

7 July 2018

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A helix-to-coil transition at the epsilon-cut site in the transmembrane dimer of the amyloid precursor protein is required for proteolysis

7 July 2018

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Structural studies of the transmembrane C-terminal domain of the amyloid precursor protein (APP): does APP function as a cholesterol sensor?

7 July 2018

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Direct and potent regulation of gamma-secretase by its lipid microenvironment

7 July 2018

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Dynamics and Cleavability at the alpha-cleavage site of APP(684-726) in different lipid environments

7 July 2018

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Substrate specificity of gamma-secretase and other intramembrane proteases

7 July 2018

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Dimerization of the transmembrane domain of amyloid precursor proteins and familial Alzheimer's disease mutants

7 July 2018

1 reference

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Amyloidogenic processing but not amyloid precursor protein (APP) intracellular C-terminal domain production requires a precisely oriented APP dimer assembled by transmembrane GXXXG motifs

7 July 2018

1 reference

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Alzheimer's disease: the lipid connection

7 July 2018

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The same gamma-secretase accounts for the multiple intramembrane cleavages of APP

7 July 2018

1 reference

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The amyloid precursor protein: beyond amyloid

7 July 2018

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7 July 2018

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Longer forms of amyloid beta protein: implications for the mechanism of intramembrane cleavage by gamma-secretase.

7 July 2018

1 reference

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Heating caused by radiofrequency irradiation and sample rotation in 13C magic angle spinning NMR studies of lipid membranes

7 July 2018

1 reference

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Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes

7 July 2018

1 reference

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Model systems, lipid rafts, and cell membranes

7 July 2018

1 reference

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Dietary lipids in the aetiology of Alzheimer's disease: implications for therapy

7 July 2018

1 reference

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Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts

7 July 2018

1 reference

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Nonfibrillar diffuse amyloid deposition due to a gamma(42)-secretase site mutation points to an essential role for N-truncated A beta(42) in Alzheimer's disease

7 July 2018

1 reference

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The GxxxG motif: a framework for transmembrane helix-helix association

7 July 2018

1 reference

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Beta-amyloid precursor protein. Location of transmembrane domain and specificity of gamma-secretase cleavage

7 July 2018

1 reference

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1H, 13C and 15N chemical shift referencing in biomolecular NMR

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030151

NMRPipe: a multidimensional spectral processing system based on UNIX pipes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030151

1H, 13C and 15N random coil NMR chemical shifts of the common amino acids. I. Investigations of nearest-neighbor effects

7 July 2018

1 reference

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Lipid composition of neuronal cell bodies and neurites from cultured dorsal root ganglia

7 July 2018

1 reference

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Processing of the beta-amyloid precursor protein and its regulation in Alzheimer's disease

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030151

Relationship between nuclear magnetic resonance chemical shift and protein secondary structure

7 July 2018

1 reference

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Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

7 July 2018

1 reference

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More missense in amyloid gene.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030151

Immobilization of the influenza A M2 transmembrane peptide in virus envelope-mimetic lipid membranes: a solid-state NMR investigation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030151

Intermediate motions as studied by solid-state separated local field NMR experiments

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030151

Structure and dynamics of the HIV-1 Vpu transmembrane domain revealed by solid-state NMR with magic-angle spinning

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030151

Rotational diffusion of membrane proteins in aligned phospholipid bilayers by solid-state NMR spectroscopy.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030151

Lipids as modulators of proteolytic activity of BACE: involvement of cholesterol, glycosphingolipids, and anionic phospholipids in vitro

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030151

Determination of peptide oligomerization in lipid bilayers using 19F spin diffusion NMR.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030151

Structural role of glycine in amyloid fibrils formed from transmembrane alpha-helices

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030151

Diluting abundant spins by isotope edited radio frequency field assisted diffusion.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030151

The effect of cholesterol and monosialoganglioside (GM1) on the release and aggregation of amyloid beta-peptide from liposomes prepared from brain membrane-like lipids

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030151

Alternate aggregation pathways of the Alzheimer beta-amyloid peptide: Abeta association kinetics at endosomal pH.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030151

The transmembrane domain of the amyloid precursor protein in microsomal membranes is on both sides shorter than predicted

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030151

A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030151

Homodimerization of amyloid precursor protein and its implication in the amyloidogenic pathway of Alzheimer's disease.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030151

Amyloid fibril formation by A beta 16-22, a seven-residue fragment of the Alzheimer's beta-amyloid peptide, and structural characterization by solid state NMR

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030151

A detergent-insoluble membrane compartment contains A beta in vivo

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030151

10.1016/J.BPJ.2010.12.3696

27 October 2018

Identifiers

DOI

1 reference

2 August 2017

1 reference

2 August 2017

1 reference