(Q36948254)

English

Structural studies of the transmembrane C-terminal domain of the amyloid precursor protein (APP): does APP function as a cholesterol sensor?

scientific article published on 15 August 2008

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scholarly article

1 reference

Europe PubMed Central

17 August 2017

Structural studies of the transmembrane C-terminal domain of the amyloid precursor protein (APP): does APP function as a cholesterol sensor? (English)

1 reference

Europe PubMed Central

17 August 2017

transmembrane protein

0 references

author name string

Andrew J Beel

1

1 reference

Europe PubMed Central

17 August 2017

Charles K Mobley

2

1 reference

Europe PubMed Central

17 August 2017

Hak Jun Kim

3

1 reference

Europe PubMed Central

17 August 2017

Fang Tian

4

1 reference

Europe PubMed Central

17 August 2017

Arina Hadziselimovic

5

1 reference

Europe PubMed Central

17 August 2017

Bing Jap

6

1 reference

Europe PubMed Central

17 August 2017

James H Prestegard

7

1 reference

Europe PubMed Central

17 August 2017

Charles R Sanders

8

1 reference

Europe PubMed Central

17 August 2017

language of work or name

0 references

publication date

15 August 2008

1 reference

Europe PubMed Central

17 August 2017

1 reference

Europe PubMed Central

17 August 2017

47

1 reference

Europe PubMed Central

17 August 2017

9428-9446

1 reference

Europe PubMed Central

17 August 2017

36

1 reference

Europe PubMed Central

17 August 2017

Dynamics and Cleavability at the alpha-cleavage site of APP(684-726) in different lipid environments

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572687

29 September 2017

Impact of cholesterol level upon APP and BACE proximity and APP cleavage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572687

29 September 2017

C-terminal 37 residues of LRP promote the amyloidogenic processing of APP independent of FE65

1 reference

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29 September 2017

Protein aggregation in the brain: the molecular basis for Alzheimer's and Parkinson's diseases

1 reference

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29 September 2017

Flotillin-dependent clustering of the amyloid precursor protein regulates its endocytosis and amyloidogenic processing in neurons.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572687

29 September 2017

Substrate specificity of gamma-secretase and other intramembrane proteases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572687

29 September 2017

Dimerization of the transmembrane domain of amyloid precursor proteins and familial Alzheimer's disease mutants

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572687

29 September 2017

Local and global structure of the monomeric subunit of the potassium channel KcsA probed by NMR.

1 reference

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29 September 2017

Familial Alzheimer's disease mutations alter the stability of the amyloid beta-protein monomer folding nucleus

1 reference

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29 September 2017

Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1

1 reference

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29 September 2017

Alpha-secretase as a therapeutic target

1 reference

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29 September 2017

Preparation, functional characterization, and NMR studies of human KCNE1, a voltage-gated potassium channel accessory subunit associated with deafness and long QT syndrome

1 reference

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29 September 2017

Amyloid beta-protein precursor juxtamembrane domain regulates specificity of gamma-secretase-dependent cleavages

1 reference

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29 September 2017

ApoER2 expression increases Abeta production while decreasing Amyloid Precursor Protein (APP) endocytosis: Possible role in the partitioning of APP into lipid rafts and in the regulation of gamma-secretase activity.

1 reference

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29 September 2017

The LDL receptor-related protein (LRP) family: an old family of proteins with new physiological functions

1 reference

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29 September 2017

GxxxG motifs within the amyloid precursor protein transmembrane sequence are critical for the etiology of Abeta42.

1 reference

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29 September 2017

The cholesterol transporter ABCG1 modulates the subcellular distribution and proteolytic processing of beta-amyloid precursor protein

1 reference

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29 September 2017

Amyloid precursor protein and BACE function as oligomers

1 reference

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29 September 2017

Elucidating amyloid beta-protein folding and assembly: A multidisciplinary approach

1 reference

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29 September 2017

Solution NMR of membrane proteins: practice and challenges

1 reference

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29 September 2017

The gamma-secretase complex: membrane-embedded proteolytic ensemble

1 reference

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29 September 2017

Molecular structure of amyloid fibrils: insights from solid-state NMR.

1 reference

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29 September 2017

Electron microscopic structure of purified, active gamma-secretase reveals an aqueous intramembrane chamber and two pores

1 reference

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29 September 2017

sorLA: sorting out APP.

1 reference

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29 September 2017

The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-beta production

1 reference

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29 September 2017

Protein denaturation and aggregation: Cellular responses to denatured and aggregated proteins

1 reference

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29 September 2017

The intracellular domain of amyloid precursor protein interacts with flotillin-1, a lipid raft protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572687

29 September 2017

The alpha-to-beta conformational transition of Alzheimer's Abeta-(1-42) peptide in aqueous media is reversible: a step by step conformational analysis suggests the location of beta conformation seeding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572687

29 September 2017

Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572687

29 September 2017

Low density lipoprotein receptor-related protein (LRP) interacts with presenilin 1 and is a competitive substrate of the amyloid precursor protein (APP) for gamma-secretase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572687

29 September 2017

The non-amyloidogenic pathway: structure and function of alpha-secretases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572687

29 September 2017

Gamma-secretase exists on the plasma membrane as an intact complex that accepts substrates and effects intramembrane cleavage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572687

29 September 2017

Nicastrin, presenilin, APH-1, and PEN-2 form active gamma-secretase complexes in mitochondria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572687

29 September 2017

Using NMRView to visualize and analyze the NMR spectra of macromolecules

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572687

29 September 2017

Folding of helical membrane proteins: the role of polar, GxxxG-like and proline motifs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572687

29 September 2017

The X-ray structure of an antiparallel dimer of the human amyloid precursor protein E2 domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572687

29 September 2017

Purification and characterization of the human gamma-secretase complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572687

29 September 2017

The low density lipoprotein receptor-related protein 1B retains beta-amyloid precursor protein at the cell surface and reduces amyloid-beta peptide production

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572687

29 September 2017

Adaptor protein interactions: modulators of amyloid precursor protein metabolism and Alzheimer's disease risk?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572687

29 September 2017

Exclusively targeting beta-secretase to lipid rafts by GPI-anchor addition up-regulates beta-site processing of the amyloid precursor protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572687

29 September 2017

Sequence motifs, polar interactions and conformational changes in helical membrane proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572687

29 September 2017

Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572687

29 September 2017

Solution studies and structural model of the extracellular domain of the human amyloid precursor protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572687

29 September 2017

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572687

29 September 2017

The intramembrane cleavage site of the amyloid precursor protein depends on the length of its transmembrane domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572687

29 September 2017

The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572687

29 September 2017

Compartmentalization of beta-secretase (Asp2) into low-buoyant density, noncaveolar lipid rafts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572687

29 September 2017

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572687

29 September 2017

Lipid rafts and signal transduction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572687

29 September 2017

Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha -secretase ADAM 10.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572687

29 September 2017

Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572687

29 September 2017

Solution structures in aqueous SDS micelles of two amyloid beta peptides of A beta(1-28) mutated at the alpha-secretase cleavage site (K16E, K16F)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572687

29 September 2017

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572687

29 September 2017

Cleavage of Alzheimer's amyloid precursor protein by alpha-secretase occurs at the surface of neuronal cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572687

29 September 2017

Effects of the amyloid precursor protein Glu693-->Gln 'Dutch' mutation on the production and stability of amyloid beta-protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572687

29 September 2017

Crystal structure of the N-terminal, growth factor-like domain of Alzheimer amyloid precursor protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572687

29 September 2017

Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572687

29 September 2017

Mechanism of the cleavage specificity of Alzheimer's disease gamma-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572687

29 September 2017

Solution structures of micelle-bound amyloid beta-(1-40) and beta-(1-42) peptides of Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572687

29 September 2017

TROSY in triple-resonance experiments: new perspectives for sequential NMR assignment of large proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572687

29 September 2017

Fe65 and the protein network centered around the cytosolic domain of the Alzheimer's beta-amyloid precursor protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572687

29 September 2017

Solution structure of amyloid beta-peptide(1-40) in a water-micelle environment. Is the membrane-spanning domain where we think it is?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572687

29 September 2017

A membrane setting for the sorting motifs present in the adenovirus E3-13.7 protein which down-regulates the epidermal growth factor receptor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572687

29 September 2017

Lysophosphatidylglycerol: a novel effective detergent for solubilizing and purifying the cystic fibrosis transmembrane conductance regulator.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572687

29 September 2017

Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572687

29 September 2017

Beta-amyloid precursor protein. Location of transmembrane domain and specificity of gamma-secretase cleavage

1 reference

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29 September 2017

Cholesterol modulates alpha-secretase cleavage of amyloid precursor protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572687

29 September 2017

NMRPipe: a multidimensional spectral processing system based on UNIX pipes

1 reference

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29 September 2017

Chemical shifts as a tool for structure determination

1 reference

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29 September 2017

X-ray crystal structure of the protease inhibitor domain of Alzheimer's amyloid beta-protein precursor

1 reference

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29 September 2017

Beta-amyloid precursor protein cleavage by a membrane-bound protease

1 reference

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29 September 2017

Amyloidogenic processing but not amyloid precursor protein (APP) intracellular C-terminal domain production requires a precisely oriented APP dimer assembled by transmembrane GXXXG motifs

1 reference

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27 June 2018

Cholesterol-dependent gamma-secretase activity in buoyant cholesterol-rich membrane microdomains

1 reference

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27 June 2018

An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

1 reference

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27 June 2018

"Secretase," Alzheimer amyloid protein precursor secreting enzyme is not sequence-specific

1 reference

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27 June 2018

Solution Structures of β Peptide and Its Constituent Fragments: Relation to Amyloid Deposition

1 reference

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27 June 2018

Sequential NMR resonance assignment and structure determination of the Kunitz-type inhibitor domain of the Alzheimer's .beta.-amyloid precursor protein

1 reference

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27 June 2018

Positioning of the Alzheimer Abeta(1-40) peptide in SDS micelles using NMR and paramagnetic probes.

1 reference

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4 September 2018

Low-density lipoprotein receptor-related protein promotes amyloid precursor protein trafficking to lipid rafts in the endocytic pathway.

1 reference

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4 September 2018

Regulation of cholesterol and sphingomyelin metabolism by amyloid-beta and presenilin.

1 reference

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4 September 2018

A structural model for the membrane-bound form of the juxtamembrane domain of the epidermal growth factor receptor

1 reference

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4 September 2018

Environment- and mutation-dependent aggregation behavior of Alzheimer amyloid beta-protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572687

4 September 2018

Unique physicochemical profile of beta-amyloid peptide variant Abeta1-40E22G protofibrils: conceivable neuropathogen in arctic mutant carriers.

1 reference

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4 September 2018

Solution NMR studies of the A beta(1-40) and A beta(1-42) peptides establish that the Met35 oxidation state affects the mechanism of amyloid formation

1 reference

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4 September 2018

An evaluation of detergents for NMR structural studies of membrane proteins.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572687

4 September 2018

Dutch, Flemish, Italian, and Arctic mutations of APP and resistance of Abeta to physiologically relevant proteolytic degradation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572687

4 September 2018

Sulindac sulfide is a noncompetitive gamma-secretase inhibitor that preferentially reduces Abeta 42 generation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572687

4 September 2018

The transmembrane domain of the amyloid precursor protein in microsomal membranes is on both sides shorter than predicted

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572687

4 September 2018

Cholesterol depletion with physiological concentrations of a statin decreases the formation of the Alzheimer amyloid Abeta peptide.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572687

4 September 2018

Phosphorylation-induced structural changes in the amyloid precursor protein cytoplasmic tail detected by NMR.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572687

4 September 2018

Association of sterol- and glycosylphosphatidylinositol-linked proteins with Drosophila raft lipid microdomains.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572687

4 September 2018

Mutations associated with a locus for familial Alzheimer's disease result in alternative processing of amyloid beta-protein precursor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572687

4 September 2018

Transient structure of the amyloid precursor protein cytoplasmic tail indicates preordering of structure for binding to cytosolic factors

1 reference

https://pubmed.ncbi.nlm.nih.gov/18702528

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Solution conformations of a peptide containing the cytoplasmic domain sequence of the beta amyloid precursor protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/18702528

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutations in the transmembrane domain of APP altering gamma-secretase specificity

1 reference

https://pubmed.ncbi.nlm.nih.gov/18702528

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thiol modification of diacylglycerol kinase: dependence upon site membrane disposition and reagent hydrophobicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/18702528

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Three-dimensional structure of an independently folded extracellular domain of human amyloid-beta precursor protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/18702528

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sequence dependence of BNIP3 transmembrane domain dimerization implicates side-chain hydrogen bonding and a tandem GxxxG motif in specific helix-helix interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/18702528

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/BI800993C

1 reference

Europe PubMed Central

17 August 2017

1 reference

Europe PubMed Central

17 August 2017

1 reference

Europe PubMed Central

17 August 2017

ResearchGate publication ID

0 references

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