(Q34541534)

2 August 2017

title

Non-catalytic functions of Pyk2 and Fyn regulate late stage adhesion in human T cells (English)

1 reference

2 August 2017

1

Nicole M Chapman

1 reference

2 August 2017

Ashley N Yoder

2

1 reference

2 August 2017

Jon C D Houtman

series ordinal

3

1 reference

2 August 2017

language of work or name

English

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publication date

27 December 2012

1 reference

2 August 2017

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2 August 2017

volume

7

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2 August 2017

issue

12

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2 August 2017

page(s)

e53011

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Creative Commons Attribution 4.0 International

2 August 2017

copyright license

start time

27 December 2012

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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Role of two adaptor molecules SLP-76 and LAT in the PI3K signaling pathway in activated T cells

7 July 2018

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Multiple pathways leading from the T‐cell antigen receptor to the actin cytoskeleton network

7 July 2018

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Cytoskeletal cross‐talk in the control of T cell antigen receptor signaling

7 July 2018

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Cooperative interactions at the SLP-76 complex are critical for actin polymerization

7 July 2018

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T cell receptor activation leads to two distinct phases of Pyk2 activation and actin cytoskeletal rearrangement in human T cells.

7 July 2018

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Cellular functions of FAK kinases: insight into molecular mechanisms and novel functions

7 July 2018

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The T cell receptor-mediated phosphorylation of Pyk2 tyrosines 402 and 580 occurs via a distinct mechanism than other receptor systems

7 July 2018

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B cell receptor-induced phosphorylation of Pyk2 and focal adhesion kinase involves integrins and the Rap GTPases and is required for B cell spreading.

7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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T-cell receptor proximal signaling via the Src-family kinases, Lck and Fyn, influences T-cell activation, differentiation, and tolerance

7 July 2018

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7 July 2018

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7 July 2018

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Structural and Functional Evidence that Nck Interaction with CD3ε Regulates T-Cell Receptor Activity

7 July 2018

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7 July 2018

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The actin cytoskeleton in T cell activation

7 July 2018

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7 July 2018

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Reciprocal regulation of SH3 and SH2 domain binding via tyrosine phosphorylation of a common site in CD3epsilon

7 July 2018

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Cellular characterization of a novel focal adhesion kinase inhibitor

7 July 2018

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Involvement of Fyn kinase in Kit and integrin-mediated Rac activation, cytoskeletal reorganization, and chemotaxis of mast cells.

7 July 2018

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Persistence of cooperatively stabilized signaling clusters drives T-cell activation

7 July 2018

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Tyrosine kinase activity and remodelling of the actin cytoskeleton are co-temporally required for degranulation by cytotoxic T lymphocytes.

7 July 2018

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Focal adhesion kinase-related protein tyrosine kinase Pyk2 in T-cell activation and function

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3531412

Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation

7 July 2018

1 reference

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TCR engagement induces proline-rich tyrosine kinase-2 (Pyk2) translocation to the T cell-APC interface independently of Pyk2 activity and in an immunoreceptor tyrosine-based activation motif-mediated fashion

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3531412

A PAK1-PIX-PKL complex is activated by the T-cell receptor independent of Nck, Slp-76 and LAT.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3531412

Protein-tyrosine kinase Pyk2 is involved in interleukin-2 production by Jurkat T cells via its tyrosine 402

7 July 2018

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T cell receptor engagement induces tyrosine phosphorylation of FAK and Pyk2 and their association with Lck.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3531412

Tyrosine phosphorylation of Pyk2 is selectively regulated by Fyn during TCR signaling

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3531412

Wortmannin, a microbial product inhibitor of myosin light chain kinase

7 July 2018

1 reference

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Dynamic actin polymerization drives T cell receptor-induced spreading: a role for the signal transduction adaptor LAT.

7 July 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0053011

Dynamic molecular interactions linking the T cell antigen receptor to the actin cytoskeleton.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0053011

Hypophosphorylated and inactive Pyk2 associates with paxillin at the microtubule organizing center in hematopoietic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0053011

The actin cytoskeleton and cytotoxic T lymphocytes: evidence for multiple roles that could affect granule exocytosis-dependent target cell killing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0053011

A Pyk2-Vav1 complex is recruited to beta3-adhesion sites to initiate Rho activation.

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0053011

A novel source of viable peripheral blood mononuclear cells from leukoreduction system chambers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0053011

Rho regulates T cell receptor ITAM-induced lymphocyte spreading in an integrin-independent manner

21 January 2018

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3531412

27 October 2018

12 December 2020

T cell costimulation via the integrin VLA-4 inhibits the actin-dependent centralization of signaling microclusters containing the adaptor SLP-76

1 reference

PubMed

12 December 2020

Studying the dynamics of SLP-76, Nck, and Vav1 multimolecular complex formation in live human cells with triple-color FRET

1 reference

PubMed

12 December 2020

A critical role for p59fyn in CD2-based signal transduction

1 reference

PubMed

12 December 2020

10.1371/JOURNAL.PONE.0053011

Identifiers

DOI

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2 August 2017

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2 August 2017

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