(Q34541753)

2 August 2017

title

Hepcidin induction by transgenic overexpression of Hfe does not require the Hfe cytoplasmic tail, but does require hemojuvelin (English)

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2 August 2017

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2

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2 August 2017

Mark D Fleming

3

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author name string

Paul J Schmidt

series ordinal

1

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2 August 2017

language of work or name

English

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publication date

13 September 2010

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2 August 2017

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2 August 2017

volume

116

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2 August 2017

issue

25

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2 August 2017

page(s)

5679-5687

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describes a project that uses

2 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3031413/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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ER stress controls iron metabolism through induction of hepcidin

7 July 2018

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ER stress-inducible factor CHOP affects the expression of hepcidin by modulating C/EBPalpha activity

7 July 2018

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Bone morphogenetic protein signaling is impaired in an HFE knockout mouse model of hemochromatosis

7 July 2018

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Interaction of the hereditary hemochromatosis protein HFE with transferrin receptor 2 is required for transferrin-induced hepcidin expression

7 July 2018

1 reference

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Lack of the bone morphogenetic protein BMP6 induces massive iron overload

7 July 2018

1 reference

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7 July 2018

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Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver

7 July 2018

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The hereditary hemochromatosis protein, HFE, inhibits iron uptake via down-regulation of Zip14 in HepG2 cells

7 July 2018

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Neogenin interacts with hemojuvelin through its two membrane-proximal fibronectin type III domains

7 July 2018

1 reference

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The transferrin receptor modulates Hfe-dependent regulation of hepcidin expression

7 July 2018

1 reference

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Hfe acts in hepatocytes to prevent hemochromatosis.

7 July 2018

1 reference

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Stimulation of an unfolded protein response impairs MHC class I expression

7 July 2018

1 reference

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Hepcidin antimicrobial peptide transgenic mice exhibit features of the anemia of inflammation

7 July 2018

1 reference

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Transferrin receptor 2: evidence for ligand-induced stabilization and redirection to a recycling pathway

7 July 2018

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Hereditary hemochromatosis protein, HFE, interaction with transferrin receptor 2 suggests a molecular mechanism for mammalian iron sensing

7 July 2018

1 reference

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Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression

7 July 2018

1 reference

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A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression

7 July 2018

1 reference

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Interaction of hemojuvelin with neogenin results in iron accumulation in human embryonic kidney 293 cells

7 July 2018

1 reference

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A mouse model of juvenile hemochromatosis

7 July 2018

1 reference

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Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload

7 July 2018

1 reference

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The molecular basis of ferroportin-linked hemochromatosis

7 July 2018

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Tails of wonder: endocytic-sorting motifs key for exogenous antigen presentation

7 July 2018

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In vitro functional analysis of human ferroportin (FPN) and hemochromatosis-associated FPN mutations

7 July 2018

1 reference

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Hepcidin in iron overload disorders

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3031413

Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3031413

Signaling the unfolded protein response from the endoplasmic reticulum.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3031413

Expression of the hereditary hemochromatosis protein HFE increases ferritin levels by inhibiting iron export in HT29 cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3031413

Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3031413

Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3031413

Severe iron deficiency anemia in transgenic mice expressing liver hepcidin

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3031413

Mutational analysis of the transferrin receptor reveals overlapping HFE and transferrin binding sites

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3031413

XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3031413

Interactions of the ectodomain of HFE with the transferrin receptor are critical for iron homeostasis in cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3031413

The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3031413

The hemochromatosis founder mutation in HLA-H disrupts beta2-microglobulin interaction and cell surface expression

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3031413

A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3031413

Topogenic signals in integral membrane proteins

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3031413

Role of the human transferrin receptor cytoplasmic domain in endocytosis: localization of a specific signal sequence for internalization

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3031413

Combined deletion of Hfe and transferrin receptor 2 in mice leads to marked dysregulation of hepcidin and iron overload.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3031413

BMP/Smad signaling is not enhanced in Hfe-deficient mice despite increased Bmp6 expression.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3031413

BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3031413

Transthyretin and amyloid in the islets of Langerhans in type-2 diabetes

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3031413

HFE modulates transferrin receptor 2 levels in hepatoma cells via interactions that differ from transferrin receptor 1-HFE interactions.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3031413

Hepcidin is decreased in TFR2 hemochromatosis

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3031413

Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in mouse hemochromatosis

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3031413

Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3031413

Hepcidin Expression Does Not Rescue the Iron-Poor Phenotype of Kupffer Cells in Hfe-Null Mice After Liver Transplantation

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3031413

Physiologic systemic iron metabolism in mice deficient for duodenal Hfe

9 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3031413

Constitutive hepcidin expression prevents iron overload in a mouse model of hemochromatosis

9 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20837779

12 December 2020

inferred from PubMed ID database lookup

The cytoplasmic and the transmembrane domains are not sufficient for class I MHC signal transduction

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20837779

12 December 2020

inferred from PubMed ID database lookup

Juvenile hemochromatosis associated with pathogenic mutations of adult hemochromatosis genes

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20837779

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1182/BLOOD-2010-04-277954

1 reference

2 August 2017

1 reference

2 August 2017

1 reference