(Q34550867)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21162542%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

title

Proton transfer facilitated by ligand binding. An energetic analysis of the catalytic mechanism of Trypanosoma cruzi trans-sialidase (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21162542%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

0 references

1 reference

Gustavo Pierdominici-Sottile

series ordinal

1

1 reference

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18 January 2020

2

Adrian E Roitberg

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21162542%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

language of work or name

English

0 references

publication date

11 January 2011

1 reference

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18 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21162542%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

volume

50

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21162542%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

issue

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21162542%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

page(s)

836-842

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21162542%20AND%20SRC:MED&resulttype=core&format=json

Internal proton transfer in the external pyridoxal 5'-phosphate Schiff base in dopa decarboxylase

18 January 2020

cites work

1 reference

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Advances in quantum and molecular mechanical (QM/MM) simulations for organic and enzymatic reactions

7 July 2018

1 reference

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Modulation of catalytic function by differential plasticity of the active site: case study of Trypanosoma cruzi trans-sialidase and Trypanosoma rangeli sialidase

7 July 2018

1 reference

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A combined quantum mechanical and molecular mechanical study of the reaction mechanism and alpha-amino acidity in alanine racemase

7 July 2018

1 reference

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Comparison of multiple Amber force fields and development of improved protein backbone parameters

7 July 2018

1 reference

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Structural basis of perturbed pKa values of catalytic groups in enzyme active sites

7 July 2018

1 reference

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Thymocyte depletion in Trypanosoma cruzi infection is mediated by trans-sialidase-induced apoptosis on nurse cells complex

7 July 2018

1 reference

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Chemical diversity in the sialic acids and related alpha-keto acids: an evolutionary perspective.

7 July 2018

1 reference

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Uracil-DNA glycosylase acts by substrate autocatalysis

7 July 2018

1 reference

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Catalysis by hen egg-white lysozyme proceeds via a covalent intermediate

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3033446

Microscopic pKa values of Escherichia coli thioredoxin.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3033446

Sialic acids as ligands in recognition phenomena.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3033446

Sialidases: structures, biological significance and therapeutic potential

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3033446

Energy considerations show that low-barrier hydrogen bonds do not offer a catalytic advantage over ordinary hydrogen bonds

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3033446

The pKa of the general acid/base carboxyl group of a glycosidase cycles during catalysis: a 13C-NMR study of bacillus circulans xylanase

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3033446

A proteolytic fragment of Trypanosoma cruzi trans-sialidase lacking the carboxyl-terminal domain is active, monomeric, and generates antibodies that inhibit enzymatic activity.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3033446

Glycosylation mutants of animal cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3033446

Mechanism and stereoelectronic effects in the lysozyme reaction

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3033446

Structure of the triosephosphate isomerase-phosphoglycolohydroxamate complex: an analogue of the intermediate on the reaction pathway

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3033446

A novel cell surface trans-sialidase of trypanosoma cruzi generates a stage-specific epitope required for invasion of mammalian cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3033446

A priori evaluation of aqueous polarization effects through Monte Carlo QM-MM simulations.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3033446

Energetics of enzyme catalysis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3033446

The reaction mechanism of paraoxon hydrolysis by phosphotriesterase from combined QM/MM simulations

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3033446

A combined QM/MM approach to protein--ligand interactions: polarization effects of the HIV-1 protease on selected high affinity inhibitors

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3033446

Structural insights into the catalytic mechanism of Trypanosoma cruzi trans-sialidase

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3033446

Reaction-path energetics and kinetics of the hydride transfer reaction catalyzed by dihydrofolate reductase

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3033446

Trypanosoma cruzi trans-sialidase operates through a covalent sialyl-enzyme intermediate: tyrosine is the catalytic nucleophile

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3033446

Importance of substrate and cofactor polarization in the active site of dihydrofolate reductase

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3033446

PDDG/PM3 and PDDG/MNDO: improved semiempirical methods.

27 October 2018

1 reference

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Identification and pKa determination of the histidine residues of human low-molecular-weight phosphotyrosyl protein phosphatases: a convenient approach using an MLEV-17 spectral editing scheme

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3033446

Calculations of enzymatic reactions: calculations of pKa, proton transfer reactions, and general acid catalysis reactions in enzymes.

27 October 2018

1 reference

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Enzymatic characterization of beta-D-galactoside alpha 2,3-trans-sialidase from Trypanosoma cruzi

27 October 2018

1 reference

12 December 2020

Sialic acids: fascinating sugars in higher animals and man

1 reference

12 December 2020

Primary13C and β-Secondary2H KIEs for Trans-sialidase. A Snapshot of Nucleophilic Participation during Catalysis†

1 reference

12 December 2020

pK(a) calculations for class C beta-lactamases: the role of Tyr-150

1 reference

12 December 2020

The action of Trypanosoma cruzi trans-sialidase on glycolipids and glycoproteins

1 reference

12 December 2020

Simulation of the enzyme reaction mechanism of malate dehydrogenase

1 reference

12 December 2020

Identifiers

DOI

10.1021/BI101648Z

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21162542%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21162542%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

PubMed publication ID

21162542

1 reference