(Q34562198)

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Temperature-dependent structural changes of Parkinson's alpha-synuclein reveal the role of pre-existing oligomers in alpha-synuclein fibrillization

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Europe PubMed Central

PubMed publication ID

3 August 2017

Temperature-dependent structural changes of Parkinson's alpha-synuclein reveal the role of pre-existing oligomers in alpha-synuclein fibrillization (English)

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Europe PubMed Central

PubMed publication ID

3 August 2017

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Parkinson's disease

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based on heuristic

inferred from title

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based on heuristic

inferred from title

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Yun-Ru Chen

4

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author name string

Winny Ariesandi

1

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Europe PubMed Central

PubMed publication ID

3 August 2017

Chi-Fon Chang

2

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Europe PubMed Central

PubMed publication ID

3 August 2017

Tseng-Erh Chen

3

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Europe PubMed Central

PubMed publication ID

3 August 2017

language of work or name

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publication date

22 January 2013

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Europe PubMed Central

PubMed publication ID

3 August 2017

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Europe PubMed Central

PubMed publication ID

3 August 2017

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Europe PubMed Central

PubMed publication ID

3 August 2017

1

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

e53487

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Europe PubMed Central

PubMed publication ID

3 August 2017

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Creative Commons Attribution 4.0 International

22 January 2013

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April 2022 Public Data File from Crossref

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The E. coli CsgB nucleator of curli assembles to β-sheet oligomers that alter the CsgA fibrillization mechanism

1 reference

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7 July 2018

α-Synuclein in central nervous system and from erythrocytes, mammalian cells, and Escherichia coli exists predominantly as disordered monomer

1 reference

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7 July 2018

A soluble α-synuclein construct forms a dynamic tetramer

1 reference

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7 July 2018

α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation

1 reference

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7 July 2018

In vivo demonstration that alpha-synuclein oligomers are toxic

1 reference

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Distinct effects of Zn2+, Cu2+, Fe3+, and Al3+ on amyloid-beta stability, oligomerization, and aggregation: amyloid-beta destabilization promotes annular protofibril formation

1 reference

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Preparation and Characterization of Neurotoxic Tau Oligomers

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7 July 2018

Parkinson's Disease: Genetics and Pathogenesis

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Differential phospholipid binding of alpha-synuclein variants implicated in Parkinson's disease revealed by solution NMR spectroscopy

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Exogenous alpha-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells

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7 July 2018

Pre-fibrillar alpha-synuclein variants with impaired beta-structure increase neurotoxicity in Parkinson's disease models

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7 July 2018

Amyloid beta-protein assembly and Alzheimer disease

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7 July 2018

Dissociation of amyloid fibrils of alpha-synuclein in supercooled water.

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7 July 2018

Characterization of conformational and dynamic properties of natively unfolded human and mouse alpha-synuclein ensembles by NMR: implication for aggregation.

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7 July 2018

Phosphorylation at Ser-129 but not the phosphomimics S129E/D inhibits the fibrillation of alpha-synuclein.

1 reference

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7 July 2018

Neurodegenerative diseases: new concepts of pathogenesis and their therapeutic implications

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Identification of in vivo phosphorylation sites and their functional significance in the sodium iodide symporter.

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7 July 2018

Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models

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7 July 2018

Molecular structure of amyloid fibrils: insights from solid-state NMR.

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7 July 2018

Recent atomic models of amyloid fibril structure

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7 July 2018

Snaring the function of alpha-synuclein

1 reference

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7 July 2018

Release of long-range tertiary interactions potentiates aggregation of natively unstructured alpha-synuclein

1 reference

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7 July 2018

Self-propagating, molecular-level polymorphism in Alzheimer's beta-amyloid fibrils

1 reference

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7 July 2018

Role of individual methionines in the fibrillation of methionine-oxidized alpha-synuclein

1 reference

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7 July 2018

Does alpha-synuclein modulate dopaminergic synaptic content and tone at the synapse?

1 reference

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7 July 2018

Dissociation of amyloid fibrils of alpha-synuclein and transthyretin by pressure reveals their reversible nature and the formation of water-excluded cavities

1 reference

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7 July 2018

Effect of familial Parkinson's disease point mutations A30P and A53T on the structural properties, aggregation, and fibrillation of human alpha-synuclein

1 reference

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7 July 2018

Amyloid beta-protein oligomerization: prenucleation interactions revealed by photo-induced cross-linking of unmodified proteins

1 reference

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7 July 2018

Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy

1 reference

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Alpha-synuclein in Lewy bodies

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NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded

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How to measure and predict the molar absorption coefficient of a protein

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7 July 2018

Identification of two distinct synucleins from human brain

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7 July 2018

Evidence for a partially folded intermediate in alpha-synuclein fibril formation

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21 January 2018

Raman spectroscopic characterization of secondary structure in natively unfolded proteins: alpha-synuclein

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21 January 2018

Accelerated fibrillation of alpha-synuclein induced by the combined action of macromolecular crowding and factors inducing partial folding

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21 January 2018

Amyloid fibril formation of alpha-synuclein is accelerated by preformed amyloid seeds of other proteins: implications for the mechanism of transmissible conformational diseases

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21 January 2018

Alpha-synuclein selectively binds to anionic phospholipids embedded in liquid-disordered domains.

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21 January 2018

A new method for purification of recombinant human alpha-synuclein in Escherichia coli.

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SDS-induced fibrillation of alpha-synuclein: an alternative fibrillation pathway.

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21 January 2018

Temperature-dependent structural changes in intrinsically disordered proteins: formation of alpha-helices or loss of polyproline II?

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21 January 2018

Impact of the acidic C-terminal region comprising amino acids 109-140 on alpha-synuclein aggregation in vitro

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21 January 2018

Distinct roles of the N-terminal-binding domain and the C-terminal-solubilizing domain of alpha-synuclein, a molecular chaperone

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21 January 2018

Role of alpha-synuclein carboxy-terminus on fibril formation in vitro

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21 January 2018

The Conformation and the Aggregation Kinetics of α-Synuclein Depend on the Proline Residues in Its C-Terminal Region

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21 January 2018

Are there temperature-dependent structural transitions in the "intrinsically unstructured" protein prothymosin alpha?

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27 October 2018

Mapping Long-Range Interactions in α-Synuclein using Spin-Label NMR and Ensemble Molecular Dynamics Simulations

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21 January 2018

Structural properties of semenogelin I

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Familial Mutants of α-Synuclein with Increased Neurotoxicity Have a Destabilized Conformation

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The role of the C-terminus of human α-synuclein: intra-disulfide bonds between the C-terminus and other regions stabilize non-fibrillar monomeric isomers

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The early events of alpha-synuclein oligomerization revealed by photo-induced cross-linking

1 reference

https://pubmed.ncbi.nlm.nih.gov/23349712

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0053487

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

2013PLoSO...853487A

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PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

ResearchGate publication ID

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