(Q34566736)

English

Trabectedin (ET-743, Yondelis) is a substrate for P-glycoprotein, but only high expression of P-glycoprotein confers the multidrug resistance phenotype

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Trabectedin (ET-743, Yondelis) is a substrate for P-glycoprotein, but only high expression of P-glycoprotein confers the multidrug resistance phenotype (English)

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

multiple drug resistance

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

object named as

Tessa Buckle

2

0 references

7

object named as

Jos H Beijnen

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Jan H M Schellens

6

object named as

Jan H M Schellens

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

author name string

Jan-Hendrik Beumer

1

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Mariet Ouwehand

3

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Niels E F Franke

4

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Luis Lopez-Lazaro

5

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Olaf van Tellingen

8

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

language of work or name

1 reference

based on heuristic

inferred from title

publication date

1 February 2007

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Investigational New Drugs

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

25

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Europe PubMed Central

PubMed publication ID

3 August 2017

1

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Europe PubMed Central

PubMed publication ID

3 August 2017

1-7

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Europe PubMed Central

PubMed publication ID

3 August 2017

https://scigraph.springernature.com/pub.10.1007/s10637-006-7773-9

0 references

Expression of mdr1 and gst-pi in human breast tumours: comparison to in vitro chemosensitivity

1 reference

https://api.crossref.org/works/10.1007%2FS10637-006-7773-9

21 January 2018

P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/16633714

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A new PCR MIMIC strategy to quantify low mdr1 mRNA levels in drug resistant cell lines and AML blast samples

1 reference

https://pubmed.ncbi.nlm.nih.gov/16633714

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitative polymerase chain reaction analysis of mdr1 mRNA in multiple myeloma cell lines and clinical specimens

1 reference

https://pubmed.ncbi.nlm.nih.gov/16633714

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular characterisation of two human cancer cell lines selected in vitro for their chemotherapeutic drug resistance to ET-743.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16633714

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ecteinascidin 743, a transcription-targeted chemotherapeutic that inhibits MDR1 activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16633714

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sequence-dependent synergistic cytotoxicity of ecteinascidin-743 and paclitaxel in human breast cancer cell lines in vitro and in vivo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16633714

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Extensive contribution of the multidrug transporters P-glycoprotein and Mrp1 to basal drug resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/16633714

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitative analysis of MDR1 (multidrug resistance) gene expression in human tumors by polymerase chain reaction

1 reference

https://pubmed.ncbi.nlm.nih.gov/16633714

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A phase II study of ET-743/trabectedin ('Yondelis') for patients with advanced gastrointestinal stromal tumours

1 reference

https://pubmed.ncbi.nlm.nih.gov/16633714

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of P-glycoprotein in pharmacokinetics: clinical implications

1 reference

https://pubmed.ncbi.nlm.nih.gov/16633714

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Levels of multidrug resistance (MDR1) P-glycoprotein expression by human breast cancer correlate with in vitro resistance to taxol and doxorubicin.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16633714

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of P-glycoprotein in breast cancer tissue and in vitro resistance to doxorubicin and vincristine

1 reference

https://pubmed.ncbi.nlm.nih.gov/16633714

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux

1 reference

https://pubmed.ncbi.nlm.nih.gov/16633714

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolation and characterization of an IGROV-1 human ovarian cancer cell line made resistant to Ecteinascidin-743 (ET-743).

1 reference

https://pubmed.ncbi.nlm.nih.gov/16633714

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Yondelis (trabectedin, ET-743): the development of an anticancer agent of marine origin

1 reference

https://pubmed.ncbi.nlm.nih.gov/16633714

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1 reference

https://pubmed.ncbi.nlm.nih.gov/16633714

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA sequence- and structure-selective alkylation of guanine N2 in the DNA minor groove by ecteinascidin 743, a potent antitumor compound from the Caribbean tunicate Ecteinascidia turbinata

1 reference

https://pubmed.ncbi.nlm.nih.gov/16633714

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A phase II and pharmacokinetic study of ecteinascidin 743 in patients with gastrointestinal stromal tumors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16633714

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overcoming multidrug drug resistance in P-glycoprotein/MDR1-overexpressing cell lines by ecteinascidin 743.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16633714

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interference of transcriptional activation by the antineoplastic drug ecteinascidin-743.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16633714

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multidrug resistance P-glycoprotein: crucial significance in drug disposition and interaction.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16633714

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

P-Glycoprotein, a gatekeeper in the blood-brain barrier

1 reference

https://pubmed.ncbi.nlm.nih.gov/16633714

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase II study of ecteinascidin 743 in heavily pretreated patients with recurrent osteosarcoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/16633714

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Progress in the development and acquisition of anticancer agents from marine sources.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16633714

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase II and pharmacokinetic study of ecteinascidin 743 in patients with progressive sarcomas of soft tissues refractory to chemotherapy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16633714

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Importance of P-glycoprotein for drug disposition in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/16633714

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/16633714

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitative reverse transcriptase-polymerase chain reaction measured expression of MDR1 and MRP in primary breast carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/16633714

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S10637-006-7773-9

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Dimensions Publication ID

0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

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