(Q34572081)

3 August 2017

1 reference

title

Telomerase: biology and phase I trials (English)

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3 August 2017

phase I clinical trial

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author name string

L R Kelland

series ordinal

1

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PubMed ID

11905801

3 August 2017

language of work or name

1 reference

1 February 2001

1 reference

Lancet Oncology Commission

3 August 2017

1 reference

3 August 2017

2

1 reference

3 August 2017

95-102

1 reference

3 August 2017

2

1 reference

3 August 2017

The Hallmarks of Cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900226-6

7 January 2021

Discovering novel chemotherapeutic drugs for the third millennium

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900226-6

7 January 2021

Structure and function of telomeres

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900226-6

7 January 2021

Telomere reduction in human colorectal carcinoma and with ageing

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900226-6

7 January 2021

The role of senescence and immortalization in carcinogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900226-6

7 January 2021

https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900226-6

1 reference

7 January 2021

Telomere states and cell fates

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900226-6

7 January 2021

The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900226-6

7 January 2021

Specific association of human telomerase activity with immortal cells and cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900226-6

7 January 2021

The RNA component of human telomerase

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900226-6

7 January 2021

hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900226-6

7 January 2021

Control of telomere length by the human telomeric protein TRF1

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900226-6

7 January 2021

TIN2, a new regulator of telomere length in human cells

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900226-6

7 January 2021

Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900226-6

7 January 2021

Tankyrase promotes telomere elongation in human cells

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900226-6

7 January 2021

Mammalian telomeres end in a large duplex loop

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900226-6

7 January 2021

Studies of the molecular mechanisms in the regulation of telomerase activity

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900226-6

7 January 2021

The Wilms' tumor 1 tumor suppressor gene represses transcription of the human telomerase reverse transcriptase gene

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900226-6

7 January 2021

Expression of TERT in early premalignant lesions and a subset of cells in normal tissues.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900226-6

7 January 2021

Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900226-6

7 January 2021

Creation of human tumour cells with defined genetic elements

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900226-6

7 January 2021

Short dysfunctional telomeres impair tumorigenesis in the INK4a(delta2/3) cancer-prone mouse

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900226-6

7 January 2021

Role of telomerase in cellular proliferation and cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900226-6

7 January 2021

Role of telomerase in cell senescence and oncogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900226-6

7 January 2021

Non-radioactive measurement of telomerase activity in human bladder cancer, bladder washings, and in urine

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900226-6

7 January 2021

Immuno-histochemical detection of human telomerase catalytic component, hTERT, in human colorectal tumor and non-tumor tissue sections.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900226-6

7 January 2021

Correlating telomerase activity levels with human neuroblastoma outcomes

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900226-6

7 January 2021

Telomerase activity and survival of patients with node-positive breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900226-6

7 January 2021

Inhibition of telomerase activity by cisplatin in human testicular cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900226-6

7 January 2021

Extension of life-span by introduction of telomerase into normal human cells

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900226-6

7 January 2021

Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900226-6

7 January 2021

Essential role of mouse telomerase in highly proliferative organs

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900226-6

7 January 2021

The telomerase challenge - an unusual problem in drug discovery

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900226-6

7 January 2021

Cellular delivery of peptide nucleic acids and inhibition of human telomerase

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900226-6

7 January 2021

Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900226-6

7 January 2021

A hexameric phosphorothioate oligonucleotide telomerase inhibitor arrests growth of Burkitt's lymphoma cells in vitro and in vivo.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900226-6

7 January 2021

Targeted therapy of human malignant glioma in a mouse model by 2-5A antisense directed against telomerase RNA.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900226-6

7 January 2021

Treatment of prostate cancer in vitro and in vivo with 2-5A-anti-telomerase RNA component.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900226-6

7 January 2021

Inhibition of telomerase limits the growth of human cancer cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900226-6

7 January 2021

Telomere shortening and apoptosis in telomerase-inhibited human tumor cells

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900226-6

7 January 2021

Effects of reverse transcriptase inhibitors on telomere length and telomerase activity in two immortalized human cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900226-6

7 January 2021

Irreversible telomere shortening by 3'-azido-2',3'-dideoxythymidine (AZT) treatment

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900226-6

7 January 2021

G-quadruplex DNA: a target for drug design

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900226-6

7 January 2021

Inhibition of human telomerase by a G-quadruplex-interactive compound

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900226-6

7 January 2021

Human telomerase inhibition by regioisomeric disubstituted amidoanthracene-9,10-diones

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900226-6

7 January 2021

Human telomerase inhibition by substituted acridine derivatives

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900226-6

7 January 2021

A human breast cancer model for the study of telomerase inhibitors based on a new biotinylated-primer extension assay.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900226-6

7 January 2021

Isothiazolone derivatives selectively inhibit telomerase from human and rat cancer cells in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900226-6

7 January 2021

Telomerase inhibition, telomere shortening, and senescence of cancer cells by tea catechins

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900226-6

7 January 2021

Telomere length regulation during postnatal development and ageing in Mus spretus

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900226-6

7 January 2021

Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900226-6

7 January 2021

Telomere length dynamics in human lymphocyte subpopulations measured by flow cytometry.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900226-6

7 January 2021

Telomere length and telomerase activity in malignant lymphomas at diagnosis and relapse

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2800%2900226-6

7 January 2021

10.1016/S1470-2045(00)00226-6

Identifiers

DOI

1 reference

3 August 2017

1 reference

PubMed ID

11905801