(Q34580333)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25305013%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

title

Artesunate induces cell death in human cancer cells via enhancing lysosomal function and lysosomal degradation of ferritin (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25305013%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

0 references

1 reference

5

1 reference

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21 February 2020

Han-Ming Shen

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25305013%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

author name string

Nai-Di Yang

1

1 reference

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21 February 2020

Shi-Hao Tan

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25305013%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

Shukie Ng

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25305013%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

Yin Shi

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25305013%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

Kevin Shyong Wei Tan

6

1 reference

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21 February 2020

Wai-Shiu Fred Wong

7

1 reference

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21 February 2020

language of work or name

English

0 references

publication date

10 October 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25305013%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

21 February 2020

published in

1 reference

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21 February 2020

volume

289

1 reference

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21 February 2020

issue

48

1 reference

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21 February 2020

page(s)

33425-33441

1 reference

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describes a project that uses

21 February 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4246098/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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Artemisinin derivative artesunate induces radiosensitivity in cervical cancer cells in vitro and in vivo

7 July 2018

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Artesunate induces G2/M cell cycle arrest through autophagy induction in breast cancer cells

7 July 2018

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7 July 2018

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Artemisinins: pharmacological actions beyond anti-malarial

7 July 2018

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Dihydroartemisinin induces autophagy by suppressing NF-κB activation

7 July 2018

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Dihydroartemisinin induces autophagy and inhibits the growth of iron-loaded human myeloid leukemia K562 cells via ROS toxicity

7 July 2018

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7 July 2018

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Iron and cancer: more ore to be mined

7 July 2018

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Initiation of apoptosis, cell cycle arrest and autophagy of esophageal cancer cells by dihydroartemisinin

7 July 2018

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Activation of lysosomal function in the course of autophagy via mTORC1 suppression and autophagosome-lysosome fusion.

7 July 2018

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Mitoferrin-2-dependent mitochondrial iron uptake sensitizes human head and neck squamous carcinoma cells to photodynamic therapy

7 July 2018

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Development of artemisinin compounds for cancer treatment

7 July 2018

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Lysosomal iron, iron chelation, and cell death

7 July 2018

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Mechanisms of mammalian iron homeostasis

7 July 2018

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Artesunate induces apoptosis via a Bak-mediated caspase-independent intrinsic pathway in human lung adenocarcinoma cells

7 July 2018

1 reference

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Lysosomal acidification mechanisms

7 July 2018

1 reference

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Lysosomal signaling enhances mitochondria-mediated photodynamic therapy in A431 cancer cells: role of iron

7 July 2018

1 reference

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Autophagy: renovation of cells and tissues

7 July 2018

1 reference

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Artesunate enhances radiosensitivity of human non-small cell lung cancer A549 cells via increasing NO production to induce cell cycle arrest at G2/M phase

7 July 2018

1 reference

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Anti-malarial drug artesunate attenuates experimental allergic asthma via inhibition of the phosphoinositide 3-kinase/Akt pathway

7 July 2018

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Distinct mechanisms of ferritin delivery to lysosomes in iron-depleted and iron-replete cells

7 July 2018

1 reference

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Lysosomal positioning coordinates cellular nutrient responses.

7 July 2018

1 reference

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mTOR: from growth signal integration to cancer, diabetes and ageing

7 July 2018

1 reference

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Artesunate activates mitochondrial apoptosis in breast cancer cells via iron-catalyzed lysosomal reactive oxygen species production

7 July 2018

1 reference

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The role of heme and the mitochondrion in the chemical and molecular mechanisms of mammalian cell death induced by the artemisinin antimalarials

7 July 2018

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First evidence that the antimalarial drug artesunate inhibits invasion and in vivo metastasis in lung cancer by targeting essential extracellular proteases

7 July 2018

1 reference

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Heme mediates cytotoxicity from artemisinin and serves as a general anti-proliferation target

7 July 2018

1 reference

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Artesunate induces oncosis-like cell death in vitro and has antitumor activity against pancreatic cancer xenografts in vivo

7 July 2018

1 reference

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Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function

7 July 2018

1 reference

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Specific iron chelators determine the route of ferritin degradation

7 July 2018

1 reference

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A gene network regulating lysosomal biogenesis and function

7 July 2018

1 reference

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Translocation of iron from lysosomes into mitochondria is a key event during oxidative stress-induced hepatocellular injury

7 July 2018

1 reference

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The yeast lysosome-like vacuole: endpoint and crossroads

7 July 2018

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Experimental Therapy of Hepatoma with Artemisinin and Its Derivatives: In vitro and In vivo Activity, Chemosensitization, and Mechanisms of Action

7 July 2018

1 reference

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Structure and regulation of the vacuolar ATPases

7 July 2018

1 reference

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Artesunate induces ROS-mediated apoptosis in doxorubicin-resistant T leukemia cells

7 July 2018

1 reference

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Evidence for a common non-heme chelatable-iron-dependent activation mechanism for semisynthetic and synthetic endoperoxide antimalarial drugs.

7 July 2018

1 reference

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Atg8, a ubiquitin-like protein required for autophagosome formation, mediates membrane tethering and hemifusion

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246098

In situ detection of phosphorylated platelet-derived growth factor receptor beta using a generalized proximity ligation method.

7 July 2018

1 reference

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Simple quantitative detection of mitochondrial superoxide production in live cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246098

The role of iron regulatory proteins in mammalian iron homeostasis and disease

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246098

Release of iron from ferritin requires lysosomal activity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246098

Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246098

Relocalized redox-active lysosomal iron is an important mediator of oxidative-stress-induced DNA damage

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246098

Mitochondrial formation of reactive oxygen species

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246098

Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246098

Artemisinins target the SERCA of Plasmodium falciparum

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246098

Synchronized whole cell oscillations in mitochondrial metabolism triggered by a local release of reactive oxygen species in cardiac myocytes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246098

At the acidic edge: emerging functions for lysosomal membrane proteins

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246098

The vacuolar (H+)-ATPases--nature's most versatile proton pumps

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246098

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246098

Artemisinin, an Endoperoxide Antimalarial, Disrupts the Hemoglobin Catabolism and Heme Detoxification Systems in Malarial Parasite

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246098

The ferritins: molecular properties, iron storage function and cellular regulation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246098

Cytotoxicity of artemisinin-related endoperoxides to Ehrlich ascites tumor cells.

7 July 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.564567

Inhibition of angiogenesis in vivo and growth of Kaposi's sarcoma xenograft tumors by the anti-malarial artesunate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.564567

Inhibition of human cancer cell line growth and human umbilical vein endothelial cell angiogenesis by artemisinin derivatives in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.564567

Cellular uptake and release of two contrasting iron chelators.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.564567

Overexpression of wild type and mutated human ferritin H-chain in HeLa cells: in vivo role of ferritin ferroxidase activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.564567

The artemisinin derivative artesunate inhibits corneal neovascularization by inducing ROS-dependent apoptosis in vascular endothelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.564567

Artesunate enhances TRAIL-induced apoptosis in human cervical carcinoma cells through inhibition of the NF-κB and PI3K/Akt signaling pathways.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246098

Evidence for the Involvement of Carbon-centered Radicals in the Induction of Apoptotic Cell Death by Artemisinin Compounds

27 October 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.564567

Ferritin: design and formation of an iron-storage molecule

21 January 2018

1 reference

12 December 2020

Anti-malarial drug artesunate ameliorates oxidative lung damage in experimental allergic asthma

1 reference

12 December 2020

Bafilomycin A1, a specific inhibitor of vacuolar-type H(+)-ATPase, inhibits acidification and protein degradation in lysosomes of cultured cells

1 reference

12 December 2020

Effects of vinblastine, leucine, and histidine, and 3-methyladenine on autophagy in Ehrlich ascites cells

1 reference

12 December 2020

Evidence that desferrioxamine cannot enter cells by passive diffusion

1 reference

12 December 2020

Chemical studies on qinghaosu (artemisinine). China Cooperative Research Group on qinghaosu and its derivatives as antimalarials

1 reference

12 December 2020

Reactivity of biologically important thiol compounds with superoxide and hydrogen peroxide

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M114.564567

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25305013%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25305013%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

PubMed publication ID

25305013

1 reference