(Q34580340)

3 August 2017

G Protein and β-arrestin signaling bias at the ghrelin receptor (English)

1 reference

3 August 2017

1 reference

6

Marc G Caron

1 reference

3 August 2017

Tama Evron

1

1 reference

3 August 2017

Sean M Peterson

2

1 reference

3 August 2017

Nikhil M Urs

3

1 reference

3 August 2017

Yushi Bai

4

1 reference

3 August 2017

Lauren K Rochelle

5

1 reference

3 August 2017

Larry S Barak

7

1 reference

3 August 2017

language of work or name

English

0 references

publication date

26 September 2014

1 reference

Journal of Biological Chemistry

3 August 2017

1 reference

3 August 2017

289

1 reference

3 August 2017

48

1 reference

3 August 2017

33442-33455

1 reference

describes a project that uses

3 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4246099/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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Imidazole-derived agonists for the neurotensin 1 receptor.

7 July 2018

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Functionally biased signalling properties of 7TM receptors - opportunities for drug development for the ghrelin receptor

7 July 2018

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Constitutive internalization of the leucine-rich G protein-coupled receptor-5 (LGR5) to the trans-Golgi network

7 July 2018

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Addiction therapeutics: obstacles and opportunities

7 July 2018

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Modulation of constitutive activity and signaling bias of the ghrelin receptor by conformational constraint in the second extracellular loop

7 July 2018

1 reference

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The 1,2,4-triazole as a scaffold for the design of ghrelin receptor ligands: development of JMV 2959, a potent antagonist

7 July 2018

1 reference

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Ligands and signaling proteins govern the conformational landscape explored by a G protein-coupled receptor

7 July 2018

1 reference

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Rac1 is essential in cocaine-induced structural plasticity of nucleus accumbens neurons

7 July 2018

1 reference

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Discovery of a new class of ghrelin receptor antagonists

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246099

Modeling of bias for the analysis of receptor signaling in biochemical systems

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246099

GSK1614343, a novel ghrelin receptor antagonist, produces an unexpected increase of food intake and body weight in rodents and dogs

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246099

Crystal structure of the β2 adrenergic receptor-Gs protein complex

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246099

Unique interaction pattern for a functionally biased ghrelin receptor agonist

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246099

The role of the central ghrelin system in reward from food and chemical drugs

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246099

Luciferase Reporter Assay System for Deciphering GPCR Pathways

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246099

Ghrelin-induced activation of cAMP signal transduction and its negative regulation by endocannabinoids in the hippocampus

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246099

Therapeutic potential of β-arrestin- and G protein-biased agonists.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246099

Signaling through the ghrelin receptor modulates hippocampal function and meal anticipation in mice

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246099

Pharmacological characterization of the ghrelin receptor antagonist, GSK1614343 in rat RC-4B/C cells natively expressing GHS type 1a receptors

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246099

Discovery process and characterization of novel carbohydrazide derivatives as potent and selective GHSR1a antagonists

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246099

Ghrelin receptor antagonism attenuates cocaine- and amphetamine-induced locomotor stimulation, accumbal dopamine release, and conditioned place preference

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246099

Teaching old receptors new tricks: biasing seven-transmembrane receptors

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246099

Atypical responsiveness of the orphan receptor GPR55 to cannabinoid ligands

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246099

Growth hormone secretagogues and growth hormone releasing peptides act as orthosteric super-agonists but not allosteric regulators for activation of the G protein Galpha(o1) by the Ghrelin receptor

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246099

Requirement of central ghrelin signaling for alcohol reward

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246099

Importance of constitutive activity and arrestin-independent mechanisms for intracellular trafficking of the ghrelin receptor

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246099

Ghrelin administration into tegmental areas stimulates locomotor activity and increases extracellular concentration of dopamine in the nucleus accumbens

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246099

Beta-arrestins and cell signaling

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246099

Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246099

Ghrelin controls hippocampal spine synapse density and memory performance

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246099

Cell biology of the ghrelin receptor

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246099

Expression of ghrelin receptor mRNA in the rat and the mouse brain

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246099

A beta-arrestin binding determinant common to the second intracellular loops of rhodopsin family G protein-coupled receptors

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246099

Ghrelin induces feeding in the mesolimbic reward pathway between the ventral tegmental area and the nucleus accumbens

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246099

Ghrelin: structure and function

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246099

Receptors coupled to heterotrimeric G proteins of the G12 family

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246099

Common structural basis for constitutive activity of the ghrelin receptor family

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246099

Desensitization and endocytosis mechanisms of ghrelin-activated growth hormone secretagogue receptor 1a.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246099

'Location, location, location': activation and targeting of MAP kinases by G protein-coupled receptors

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246099

Minireview: ghrelin and the regulation of energy balance--a hypothalamic perspective

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246099

Molecular determinants underlying the formation of stable intracellular G protein-coupled receptor-beta-arrestin complexes after receptor endocytosis*

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246099

A role for ghrelin in the central regulation of feeding

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246099

Constitutive arrestin-mediated desensitization of a human vasopressin receptor mutant associated with nephrogenic diabetes insipidus

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246099

The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246099

The MAPK/ERK cascade targets both Elk-1 and cAMP response element-binding protein to control long-term potentiation-dependent gene expression in the dentate gyrus in vivo.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246099

Differential affinities of visual arrestin, beta arrestin1, and beta arrestin2 for G protein-coupled receptors delineate two major classes of receptors

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246099

Ghrelin is a growth-hormone-releasing acylated peptide from stomach

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246099

Association of beta-arrestin with G protein-coupled receptors during clathrin-mediated endocytosis dictates the profile of receptor resensitization

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246099

Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246099

Peptidomimetic regulation of growth hormone secretion

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246099

Molecular analysis of rat pituitary and hypothalamic growth hormone secretagogue receptors

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246099

A receptor in pituitary and hypothalamus that functions in growth hormone release

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246099

Hydrophobic amino acid in the i2 loop plays a key role in receptor-G protein coupling.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246099

The Rho family GTPases RhoA, Rac1, and CDC42Hs regulate transcriptional activation by SRF

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246099

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246099

Rapid changes of mitochondrial Ca2+ revealed by specifically targeted recombinant aequorin

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4246099

Nonpeptide and peptide growth hormone secretagogues act both as ghrelin receptor agonist and as positive or negative allosteric modulators of ghrelin signaling

7 July 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.581397

Ghrelin directly targets the ventral tegmental area to increase food motivation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.581397

Ghrelin enhances appetite and increases food intake in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.581397

Small-molecule ghrelin receptor antagonists improve glucose tolerance, suppress appetite, and promote weight loss

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.581397

Regulation of ERK1/2 activity by ghrelin-activated growth hormone secretagogue receptor 1A involves a PLC/PKCvarepsilon pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.581397

Evolutionary trace of G protein-coupled receptors reveals clusters of residues that determine global and class-specific functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.581397

Enhanced gastrointestinal motility with orally active ghrelin receptor agonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.581397

New trisubstituted 1,2,4-triazole derivatives as potent ghrelin receptor antagonists. 3. Synthesis and pharmacological in vitro and in vivo evaluations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.581397

Local infusion of ghrelin enhanced hippocampal synaptic plasticity and spatial memory through activation of phosphoinositide 3-kinase in the dentate gyrus of adult rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.581397

Effects of acute and repeated intravenous administration of L-692,585, a novel non-peptidyl growth hormone secretagogue, on plasma growth hormone, IGF-1, ACTH, cortisol, prolactin, insulin, and thyroxine levels in beagles

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25261469

12 December 2020

inferred from PubMed ID database lookup

Discovery of aminofurazan-azabenzimidazoles as inhibitors of Rho-kinase with high kinase selectivity and antihypertensive activity

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25261469

12 December 2020

inferred from PubMed ID database lookup

Peptidomimetic Regulation of Growth Hormone Secretion

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25261469

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1074/JBC.M114.581397

1 reference

3 August 2017

1 reference

3 August 2017

1 reference