(Q34592125)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23422672%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

title

Single-cell and subcellular pharmacokinetic imaging allows insight into drug action in vivo (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23422672%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23422672%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

Thomas Reiner

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23422672%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

Rainer H Kohler

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23422672%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

Peter K. Sorger

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23422672%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

Ralph Weissleder

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23422672%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

2

Katy S Yang

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23422672%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

author name string

Tim Mitchison

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23422672%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

language of work or name

English

0 references

publication date

1 January 2013

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23422672%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

published in

Nature Communications

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23422672%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

volume

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23422672%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

page(s)

1504

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23422672%20AND%20SRC:MED&resulttype=core&format=json

Bioorthogonal imaging of aurora kinase A in live cells

24 February 2020

cites work

1 reference

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Imaging therapeutic PARP inhibition in vivo through bioorthogonally developed companion imaging agents

7 July 2018

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RGB marking with lentiviral vectors for multicolor clonal cell tracking

7 July 2018

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Cancer imaging by optical coherence tomography: preclinical progress and clinical potential

7 July 2018

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Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

7 July 2018

1 reference

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Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors

7 July 2018

1 reference

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7 July 2018

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Bioorthogonal probes for polo-like kinase 1 imaging and quantification.

7 July 2018

1 reference

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A systems approach for tumor pharmacokinetics

7 July 2018

1 reference

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Rapid phospho-turnover by receptor tyrosine kinases impacts downstream signaling and drug binding

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579506

Analysis of mitosis and antimitotic drug responses in tumors by in vivo microscopy and single-cell pharmacodynamics.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579506

Mechanistic rationale for inhibition of poly(ADP-ribose) polymerase in ETS gene fusion-positive prostate cancer

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579506

A high precision survey of the molecular dynamics of mammalian clathrin-mediated endocytosis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579506

Optical imaging of tumor hypoxia dynamics

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579506

Basal dynamics of p53 reveal transcriptionally attenuated pulses in cycling cells.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579506

A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579506

Structure of the EGF receptor transactivation circuit integrates multiple signals with cell context

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579506

Tumor microvasculature and microenvironment: novel insights through intravital imaging in pre-clinical models

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579506

Use of the Ki67 promoter to label cell cycle entry in living cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579506

PARP inhibition: PARP1 and beyond

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579506

The elaboration of a critical framework for understanding cancer: the cancer stem cell hypothesis.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579506

(124)I-iodopyridopyrimidinone for PET of Abl kinase-expressing tumors in vivo.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579506

Non-genetic cell-to-cell variability and the consequences for pharmacology

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579506

Structural adaptation and heterogeneity of normal and tumor microvascular networks

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579506

Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579506

Cancer stem cells: the emerging challenge of drug targeting.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579506

On the role of cell signaling models in cancer research

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579506

Intravital imaging of metastatic behavior through a mammary imaging window.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579506

4-[3-(4-cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl]-2H-phthalazin-1-one: a novel bioavailable inhibitor of poly(ADP-ribose) polymerase-1.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579506

Red/near-infrared boron-dipyrromethene dyes as strongly emitting fluorophores.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579506

Visualizing spatiotemporal dynamics of multicellular cell-cycle progression

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579506

Imaging tumor cell movement in vivo

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579506

Limited tissue penetration of taxanes: a mechanism for resistance in solid tumors

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579506

CellProfiler: free, versatile software for automated biological image analysis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579506

Novel multiwavelength microscopic scanner for mouse imaging

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579506

Use of gene expression profiling to direct in vivo molecular imaging of lung cancer

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579506

Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579506

Tumor penetration of gefitinib (Iressa), an epidermal growth factor receptor tyrosine kinase inhibitor

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579506

Cell adhesion and signalling by cadherins and Ig-CAMs in cancer

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579506

Diversity of mechanism-based pharmacodynamic models

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579506

Population pharmacokinetics. A regulatory perspective.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579506

Biodistribution of monoclonal antibodies: scale-up from mouse to human using a physiologically based pharmacokinetic model

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579506

Microvascular permeability of normal and neoplastic tissues

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579506

Intermittent blood flow in the KHT sarcoma--flow cytometry studies using Hoechst 33342.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579506

Sensitivity and acquired resistance of BRCA1;p53-deficient mouse mammary tumors to the topoisomerase I inhibitor topotecan

7 July 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS2506

Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: a phase 2, multicentre, open-label, non-randomised study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS2506

Thiopental Pharmacokinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS2506

A two-tiered physiologically based model for dually labeled single-chain Fv-Fc antibody fragments.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS2506

Vascular permeability and microcirculation of gliomas and mammary carcinomas transplanted in rat and mouse cranial windows.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3579506

The effect of plasma protein binding on in vivo efficacy: misconceptions in drug discovery

27 October 2018

1 reference

12 December 2020

Tumor growth inhibition by olaparib in BRCA2 germline-mutated patient-derived ovarian cancer tissue xenografts

1 reference

12 December 2020

Phase II, open-label, randomized, multicenter study comparing the efficacy and safety of olaparib, a poly (ADP-ribose) polymerase inhibitor, and pegylated liposomal doxorubicin in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer

1 reference

12 December 2020

A Phase I, dose-finding and pharmacokinetic study of olaparib (AZD2281) in Japanese patients with advanced solid tumors

1 reference

12 December 2020

Identifiers

DOI

10.1038/NCOMMS2506

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23422672%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

24 February 2020

ADS bibcode

2013NatCo...4.1504T

0 references

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23422672%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

PubMed publication ID

23422672

1 reference