(Q34601086)

3 August 2017

title

Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage (English)

1 reference

3 August 2017

1 reference

Whasil Lee

1

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Farshid Guilak

object named as

Farshid Guilak

13

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author name string

Holly A Leddy

2

1 reference

3 August 2017

Yong Chen

3

1 reference

3 August 2017

Suk Hee Lee

4

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3 August 2017

Nicole A Zelenski

5

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3 August 2017

Amy L McNulty

6

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3 August 2017

Jason Wu

7

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3 August 2017

Kellie N Beicker

8

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3 August 2017

Jeffrey Coles

9

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3 August 2017

Stefan Zauscher

10

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3 August 2017

Jörg Grandl

11

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3 August 2017

Frederick Sachs

12

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3 August 2017

Wolfgang B Liedtke

14

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3 August 2017

language of work or name

English

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publication date

10 November 2014

1 reference

Proceedings of the National Academy of Sciences of the United States of America

3 August 2017

published in

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3 August 2017

volume

111

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3 August 2017

issue

47

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3 August 2017

page(s)

E5114-22

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describes a project that uses

3 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4250098/fullTextXML

inferred from PubMed Central ID database lookup

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7 July 2018

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7 July 2018

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Mutations in the mechanotransduction protein PIEZO1 are associated with hereditary xerocytosis

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7 July 2018

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7 July 2018

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7 July 2018

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Primary cilia mediate mechanotransduction through control of ATP-induced Ca2+ signaling in compressed chondrocytes.

7 July 2018

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Cytoskeletal dissolution blocks oxidant release and cell death in injured cartilage

7 July 2018

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The mechanosensitive ion channel Piezo1 is inhibited by the peptide GsMTx4

7 July 2018

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Differential curvature sensing and generating activities of dynamin isoforms provide opportunities for tissue-specific regulation.

7 July 2018

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7 July 2018

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Hyperosmolarity protects chondrocytes from mechanical injury in human articular cartilage: an experimental report.

7 July 2018

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TRPV4-mediated calcium influx into human bronchial epithelia upon exposure to diesel exhaust particles.

7 July 2018

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Mechanosensitive channels: in touch with Piezo

7 July 2018

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Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4250098

Chondroprotective role of the osmotically sensitive ion channel transient receptor potential vanilloid 4: age- and sex-dependent progression of osteoarthritis in Trpv4-deficient mice.

7 July 2018

1 reference

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Mechanical signals control SOX-9, VEGF, and c-Myc expression and cell proliferation during inflammation via integrin-linked kinase, B-Raf, and ERK1/2-dependent signaling in articular chondrocytes

7 July 2018

1 reference

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Membrane curvature controls dynamin polymerization

7 July 2018

1 reference

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Novel repression of Kcc2 transcription by REST-RE-1 controls developmental switch in neuronal chloride

7 July 2018

1 reference

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Functional characterization of TRPV4 as an osmotically sensitive ion channel in porcine articular chondrocytes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4250098

Mechanical injury and cytokines cause loss of cartilage integrity and upregulate proteins associated with catabolism, immunity, inflammation, and repair

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4250098

Chondrocyte death in mechanically injured articular cartilage--the influence of extracellular calcium

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4250098

Analyzing real-time PCR data by the comparative C(T) method

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4250098

The slow force response to stretch in atrial and ventricular myocardium from human heart: functional relevance and subcellular mechanisms

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4250098

Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4250098

Zonal changes in the three-dimensional morphology of the chondron under compression: the relationship among cellular, pericellular, and extracellular deformation in articular cartilage

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4250098

Mechanosensitive channel properties and membrane mechanics in mouse dystrophic myotubes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4250098

Dynasore, a cell-permeable inhibitor of dynamin

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4250098

Bilayer-dependent inhibition of mechanosensitive channels by neuroactive peptide enantiomers.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4250098

Mechanosensitive ion channels: molecules of mechanotransduction.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4250098

Mechanical compression of cartilage explants induces multiple time-dependent gene expression patterns and involves intracellular calcium and cyclic AMP

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4250098

Dynamin: characteristics, mechanism of action and function.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4250098

The effects of osmotic stress on the viscoelastic and physical properties of articular chondrocytes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4250098

Integrins and stretch activated ion channels; putative components of functional cell surface mechanoreceptors in articular chondrocytes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4250098

Hyper-osmotic stress induces volume change and calcium transients in chondrocytes by transmembrane, phospholipid, and G-protein pathways.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4250098

Cartilage tissue remodeling in response to mechanical forces

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4250098

Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4250098

Propagation of intercellular Ca2+ waves in mechanically stimulated articular chondrocytes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4250098

Mechanotransduction across the cell surface and through the cytoskeleton

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4250098

Stretch-activated single ion channel currents in tissue-cultured embryonic chick skeletal muscle

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4250098

Chondrocyte intracellular calcium, cytoskeletal organization, and gene expression responses to dynamic osmotic loading.

7 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1414298111

RGD-dependent integrins are mechanotransducers in dynamically compressed tissue-engineered cartilage constructs

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1414298111

Multiple clinical forms of dehydrated hereditary stomatocytosis arise from mutations in PIEZO1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1414298111

Properties and Mechanism of the Mechanosensitive Ion Channel Inhibitor GsMTx4, a Therapeutic Peptide Derived from Tarantula Venom

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1414298111

[Piezo proteins form a new class of mechanically activated ion channels].

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1414298111

Effects of stretch-activated channel blockers on [Ca2+]i and muscle damage in the mdx mouse.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1414298111

Blockade of acid-sensing ion channels protects articular chondrocytes from acid-induced apoptotic injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1414298111

Calcium signaling leads to mitochondrial depolarization in impact-induced chondrocyte death in equine articular cartilage explants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1414298111

Intracellular mechanics and mechanotransduction associated with chondrocyte deformation during pipette aspiration.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4250098

Mechanisms involved in the increase in intracellular calcium following hypotonic shock in bovine articular chondrocytes

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4250098

Inhibition of acid-sensing ion channels by amiloride protects rat articular chondrocytes from acid-induced apoptosis via a mitochondrial-mediated pathway

26 October 2018

1 reference

12 December 2020

Matrix accumulation by articular chondrocytes during mechanical stimulation is influenced by integrin-mediated cell spreading

1 reference

12 December 2020

Integrin-mediated mechanotransduction in renal vascular smooth muscle cells: activation of calcium sparks

1 reference

12 December 2020

Load-controlled compression of articular cartilage induces a transient stimulation of aggrecan gene expression

1 reference

12 December 2020

Electrophysiological Demonstration of Voltage- Activated H + Channels in Bovine Articular Chondrocytes

1 reference

12 December 2020

Mechanical compression alters proteoglycan deposition and matrix deformation around individual cells in cartilage explants

1 reference

12 December 2020

Tarantula peptide inhibits atrial fibrillation

1 reference

12 December 2020

FGF-2 is bound to perlecan in the pericellular matrix of articular cartilage, where it acts as a chondrocyte mechanotransducer

1 reference

12 December 2020

Posttraumatic osteoarthritis: a first estimate of incidence, prevalence, and burden of disease

1 reference

12 December 2020

The use of a non-ionic surfactant (P188) to save chondrocytes from necrosis following impact loading of chondral explants

1 reference

12 December 2020

Down-regulation of chondrocyte aggrecan and type-II collagen gene expression correlates with increases in static compression magnitude and duration

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.1414298111

1 reference

3 August 2017

0 references

1 reference

3 August 2017

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