(Q34602247)

3 August 2017

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title

The JNK/c-Jun cascade and Alzheimer's disease (English)

1 reference

3 August 2017

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Hitohi Okazawa

1

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3 August 2017

Steven Estus

series ordinal

2

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3 August 2017

language of work or name

English

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publication date

1 March 2002

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American Journal of Alzheimer's Disease & Other Dementias

3 August 2017

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3 August 2017

17

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3 August 2017

79-88

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3 August 2017

2

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Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

3 August 2017

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

Genetic linkage evidence for a familial Alzheimer's disease locus on chromosome 14

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

Candidate gene for the chromosome 1 familial Alzheimer's disease locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

Alpha-2 macroglobulin is genetically associated with Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

Genetic association of the low-density lipoprotein receptor-related protein gene (LRP), an apolipoprotein E receptor, with late-onset Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

Susceptibility locus for Alzheimer's disease on chromosome 10.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

Presenilin 1 binds to amyloid precursor protein directly.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

Formation of stable complexes between two Alzheimer's disease gene products: presenilin-2 and beta-amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43).

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

Alzheimer's disease: genes, proteins, and therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

Presenilin and gamma-secretase: structure meets function

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

The role of presenilins in gamma-secretase activity: catalyst or cofactor?

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

The multiple paradoxes of presenilins

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

Presenilin-1 differentially facilitates endoproteolysis of the beta-amyloid precursor protein and Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

New protease inhibitors prevent gamma-secretase-mediated production of Abeta40/42 without affecting Notch cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

Binding partners of Alzheimer's disease proteins: are they physiologically relevant?

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

Amyloid deposition as the central event in the aetiology of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

Alzheimer's disease: the amyloid cascade hypothesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

Amyloid, the presenilins and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

Age-Dependent Emergence and Progression of a Tauopathy in Transgenic Mice Overexpressing the Shortest Human Tau Isoform

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

Neurodegenerative tauopathies

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

Genetic dissection of Alzheimer's disease and related dementias: amyloid and its relationship to tau.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

PHF and PHF-like fibrils--cause or consequence?

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

Targeting small Abeta oligomers: the solution to an Alzheimer's disease conundrum?

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

Intraneuronal Abeta42 accumulation in human brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

Abeta42-positive non-pyramidal neurons around amyloid plaques in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

JNK activation is associated with intracellular beta-amyloid accumulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

Advanced Maillard reaction end products are associated with Alzheimer disease pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

Advanced glycation end products contribute to amyloidosis in Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

Hydrogen peroxide mediates amyloid beta protein toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

Alterations in calcium content and biochemical processes in cultured skin fibroblasts from aged and Alzheimer donors

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

Precursor of cdk5 activator, the 23 kDa subunit of tau protein kinase II: its sequence and developmental change in brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

Glycogen synthase kinase-3 induces Alzheimer's disease-like phosphorylation of tau: generation of paired helical filament epitopes and neuronal localisation of the kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

Protein kinase FA/GSK-3 phosphorylates tau on Ser235-Pro and Ser404-Pro that are abnormally phosphorylated in Alzheimer's disease brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

Phosphorylation of microtubule-associated protein tau by stress-activated protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

Activation and redistribution of c-jun N-terminal kinase/stress activated protein kinase in degenerating neurons in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

c-Jun contributes to amyloid beta-induced neuronal apoptosis but is not necessary for amyloid beta-induced c-jun induction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

Increased immunoreactivity for Jun- and Fos-related proteins in Alzheimer's disease: association with pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

Expression of Fos, Jun, and Krox family proteins in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

Quantitative neuronal c-fos and c-jun expression in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

Presenilin 1 suppresses the function of c-Jun homodimers via interaction with QM/Jif-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

Negative regulation of the SAPK/JNK signaling pathway by presenilin 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

A role for presenilin-1 in nuclear accumulation of Ire1 fragments and induction of the mammalian unfolded protein response

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

Cell death during development of the nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

Temporal analysis of events associated with programmed cell death (apoptosis) of sympathetic neurons deprived of nerve growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

Characterization of apoptosis in cultured rat sympathetic neurons after nerve growth factor withdrawal

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

Inhibitors of protein synthesis and RNA synthesis prevent neuronal death caused by nerve growth factor deprivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

Genetic and metabolic status of NGF-deprived sympathetic neurons saved by an inhibitor of ICE family proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

Caspase inhibition extends the commitment to neuronal death beyond cytochrome c release to the point of mitochondrial depolarization

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

Inhibition of apoptotic signaling cascades causes loss of trophic factor dependence during neuronal maturation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

Direct inhibition of c-Jun N-terminal kinase in sympathetic neurones prevents c-jun promoter activation and NGF withdrawal-induced death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

JNK3 contributes to c-Jun activation and apoptosis but not oxidative stress in nerve growth factor-deprived sympathetic neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

Induction of BIM, a proapoptotic BH3-only BCL-2 family member, is critical for neuronal apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

Dominant-negative c-Jun promotes neuronal survival by reducing BIM expression and inhibiting mitochondrial cytochrome c release

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

Apoptosis is induced by beta-amyloid in cultured central nervous system neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

Ultrastructural analysis of beta-amyloid-induced apoptosis in cultured hippocampal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

In vitro aging of beta-amyloid protein causes peptide aggregation and neurotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

beta-Amyloid-induced neuronal apoptosis requires c-Jun N-terminal kinase activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

CEP-1347/KT-7515, an inhibitor of SAPK/JNK pathway activation, promotes survival and blocks multiple events associated with Abeta-induced cortical neuron apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protect primary neurones from death

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F153331750201700209

10.1177/153331750201700209

21 January 2018

Identifiers

DOI

1 reference

release_hjmh3blw6zb7tbrkajlrwyputu

3 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/hjmh3blw6zb7tbrkajlrwyputu

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference