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Contributions of Myc to tumorigenesis
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instance of
scholarly article
1 reference
stated in
Europe PubMed Central
PubMed ID
11960695
retrieved
3 August 2017
review article
1 reference
stated in
Europe PubMed Central
title
Contributions of Myc to tumorigenesis
(English)
1 reference
stated in
Europe PubMed Central
PubMed ID
11960695
retrieved
3 August 2017
author
Javier León
object named as
Javier Leon
series ordinal
2
0 references
Martin Eilers
object named as
Martin Eilers
series ordinal
3
0 references
author name string
Werner Lutz
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed ID
11960695
retrieved
3 August 2017
language of work or name
English
0 references
publication date
1 March 2002
1 reference
stated in
Europe PubMed Central
PubMed ID
11960695
retrieved
3 August 2017
published in
Biochimica et Biophysica Acta
1 reference
stated in
Europe PubMed Central
PubMed ID
11960695
retrieved
3 August 2017
volume
1602
1 reference
stated in
Europe PubMed Central
PubMed ID
11960695
retrieved
3 August 2017
page(s)
61-71
1 reference
stated in
Europe PubMed Central
PubMed ID
11960695
retrieved
3 August 2017
issue
1
1 reference
stated in
Europe PubMed Central
PubMed ID
11960695
retrieved
3 August 2017
cites work
Deconstructing myc.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900036-7
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7 January 2021
based on heuristic
inferred from DOI database lookup
CDC6 interacts with c-Myc to inhibit E-box-dependent transcription by abrogating c-Myc/Max complex
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900036-7
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7 January 2021
based on heuristic
inferred from DOI database lookup
Myc and Max proteins possess distinct transcriptional activities
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900036-7
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7 January 2021
based on heuristic
inferred from DOI database lookup
The c-Myc protein induces cell cycle progression and apoptosis through dimerization with Max.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900036-7
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7 January 2021
based on heuristic
inferred from DOI database lookup
Oncogenic activity of the c-Myc protein requires dimerization with Max.
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
Myc and Max associate in vivo
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900036-7
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7 January 2021
based on heuristic
inferred from DOI database lookup
The transcriptional program of a human B cell line in response to Myc
1 reference
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https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900036-7
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7 January 2021
based on heuristic
inferred from DOI database lookup
Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesion
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900036-7
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7 January 2021
based on heuristic
inferred from DOI database lookup
Gene-target recognition among members of the myc superfamily and implications for oncogenesis
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900036-7
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7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of cyclin D2 gene expression by the Myc/Max/Mad network: Myc-dependent TRRAP recruitment and histone acetylation at the cyclin D2 promoter.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900036-7
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7 January 2021
based on heuristic
inferred from DOI database lookup
Binding of c-Myc to chromatin mediates mitogen-induced acetylation of histone H4 and gene activation.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900036-7
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7 January 2021
based on heuristic
inferred from DOI database lookup
Coexamination of site-specific transcription factor binding and promoter activity in living cells
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900036-7
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7 January 2021
based on heuristic
inferred from DOI database lookup
The Max network gone mad.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900036-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mlx, a new Max-like bHLHZip family member: the center stage of a novel transcription factors regulatory pathway?
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900036-7
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7 January 2021
based on heuristic
inferred from DOI database lookup
MondoA, a novel basic helix-loop-helix-leucine zipper transcriptional activator that constitutes a positive branch of a max-like network
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900036-7
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7 January 2021
based on heuristic
inferred from DOI database lookup
Mlx, a novel Max-like BHLHZip protein that interacts with the Max network of transcription factors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900036-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The essential cofactor TRRAP recruits the histone acetyltransferase hGCN5 to c-Myc
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900036-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900036-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Repression of p15INK4b expression by Myc through association with Miz-1
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900036-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
TGFbeta influences Myc, Miz-1 and Smad to control the CDK inhibitor p15INK4b
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900036-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Myc represses the p21(WAF1/CIP1) promoter and interacts with Sp1/Sp3.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900036-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The Hallmarks of Cancer
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900036-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Fibroblast lines expressing activated c-myc oncogenes are tumorigenic in nude mice and syngeneic animals
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900036-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The MYC protein activates transcription of the alpha-prothymosin gene.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900036-7
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7 January 2021
based on heuristic
inferred from DOI database lookup
Induction of apoptosis in fibroblasts by c-myc protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900036-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Analysis of C-MYC function in normal cells via conditional gene-targeted mutation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900036-7
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7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of a Myc-dependent step during the formation of active G1 cyclin-cdk complexes.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900036-7
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7 January 2021
based on heuristic
inferred from DOI database lookup
Differential modulation of cyclin gene expression by MYC
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900036-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Control of cell growth by c-Myc in the absence of cell division
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900036-7
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7 January 2021
based on heuristic
inferred from DOI database lookup
Drosophila myc regulates cellular growth during development.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900036-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Induction of cyclin E-cdk2 kinase activity, E2F-dependent transcription and cell growth by Myc are genetically separable events
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900036-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cdc25 cell-cycle phosphatase as a target of c-myc
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900036-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of CDK4 as a target of c-MYC.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900036-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Direct induction of cyclin D2 by Myc contributes to cell cycle progression and sequestration of p27.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900036-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Myc-enhanced expression of Cul1 promotes ubiquitin-dependent proteolysis and cell cycle progression
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900036-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A role for transcriptional repression of p21CIP1 by c-Myc in overcoming transforming growth factor beta -induced cell-cycle arrest
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900036-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of positively and negatively acting elements regulating expression of the E2F2 gene in response to cell growth signals
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900036-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Id2 is a retinoblastoma protein target and mediates signalling by Myc oncoproteins
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900036-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
c-Myc enhances protein synthesis and cell size during B lymphocyte development
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900036-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
c-Myc transactivation of LDH-A: implications for tumor metabolism and growth
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900036-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cyclins D1 and D2 mediate myc-induced proliferation via sequestration of p27(Kip1) and p21(Cip1).
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900036-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Myc requires distinct E2F activities to induce S phase and apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900036-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Specific protection against breast cancers by cyclin D1 ablation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900036-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Expression of P27KIP1 is prognostic and independent ofMYCN amplification in human neuroblastoma
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900036-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Telomeres. Bumps on the road to immortality.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900036-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Telomerase reverse transcriptase gene is a direct target of c-Myc but is not functionally equivalent in cellular transformation.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900036-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Creation of human tumour cells with defined genetic elements
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900036-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Correlating telomerase activity levels with human neuroblastoma outcomes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900036-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900036-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900036-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Myc activates telomerase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900036-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cellular senescence: mitotic clock or culture shock?
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900036-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Role of the INK4a locus in tumor suppression and cell mortality.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900036-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of ras-induced proliferation and cellular transformation by p16INK4.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900036-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The INK4a/ARF tumor suppressor: one gene--two products--two pathways
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900036-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900036-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Targeted disruption of the three Rb-related genes leads to loss of G(1) control and immortalization
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900036-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Escape from premature senescence is not sufficient for oncogenic transformation by Ras.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900036-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Limited overlapping roles of P15(INK4b) and P18(INK4c) cell cycle inhibitors in proliferation and tumorigenesis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900036-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900036-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900036-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900036-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Reversible tumorigenesis by MYC in hematopoietic lineages
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900036-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
c-MYC induces mammary tumorigenesis by means of a preferred pathway involving spontaneous Kras2 mutations
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900036-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Myc represses the growth arrest gene gadd45
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900036-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
c-Myc antagonizes the effect of p53 on apoptosis and p21WAF1 transactivation in K562 leukemia cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900036-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Defective repression of c-myc in breast cancer cells: A loss at the core of the transforming growth factor beta growth arrest program
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900036-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Myc downregulation by transforming growth factor beta required for activation of the p15(Ink4b) G(1) arrest pathway.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900036-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Defects in TGF-beta signaling overcome senescence of mouse keratinocytes expressing v-Ha-ras
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900036-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
MYC abrogates p53-mediated cell cycle arrest in N-(phosphonacetyl)-L-aspartate-treated cells, permitting CAD gene amplification
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900036-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
c-Myc overexpression uncouples DNA replication from mitosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900036-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Transient excess of MYC activity can elicit genomic instability and tumorigenesis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900036-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Normal and c-Myc-promoted human keratinocyte differentiation both occur via a novel cell cycle involving cellular growth and endoreplication
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900036-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
C-myc overexpression and p53 loss cooperate to promote genomic instability
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900036-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900036-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Deregulated cyclin E induces chromosome instability
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900036-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Genomic instability in Gadd45a-deficient mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900036-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
GADD45 induction of a G2/M cell cycle checkpoint
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900036-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Reversible activation of c-Myc in skin: induction of a complex neoplastic phenotype by a single oncogenic lesion
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900036-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Angiogenesis is an early event in the generation of myc-induced lymphomas
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900036-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Enforced expression of the c-myc oncogene inhibits cell differentiation by precluding entry into a distinct predifferentiation state in G0/G1.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900036-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S0304-419X(02)00036-7
1 reference
stated in
Europe PubMed Central
PubMed ID
11960695
retrieved
3 August 2017
PubMed ID
11960695
1 reference
stated in
Europe PubMed Central
PubMed ID
11960695
retrieved
3 August 2017
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