(Q34615545)

3 August 2017

title

Identification of novel determinants of resistance to lapatinib in ERBB2-amplified cancers (English)

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3 August 2017

D Cunningham

7

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Alan Ashworth

10

object named as

A Ashworth

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3 August 2017

9

C J Lord

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3 August 2017

5

A Mackay

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3 August 2017

D Wetterskog

1

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3 August 2017

K-K Shiu

2

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3 August 2017

I Chong

3

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3 August 2017

T Meijer

4

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3 August 2017

M Lambros

6

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3 August 2017

J S Reis-Filho

8

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3 August 2017

language of work or name

English

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publication date

11 March 2013

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3 August 2017

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3 August 2017

volume

33

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3 August 2017

issue

8

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3 August 2017

page(s)

966-976

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Gene expression profiling in breast cancer: classification, prognostication, and prediction

3 August 2017

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ErbB2 is necessary for induction of carcinoma cell invasion by ErbB family receptor tyrosine kinases

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Neu differentiation factor activation of ErbB-3 and ErbB-4 is cell specific and displays a differential requirement for ErbB-2.

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PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients.

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Human breast cancer cells selected for resistance to trastuzumab in vivo overexpress epidermal growth factor receptor and ErbB ligands and remain dependent on the ErbB receptor network

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PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma

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An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer

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A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer

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Phosphatidylinositol 3-kinase hyperactivation results in lapatinib resistance that is reversed by the mTOR/phosphatidylinositol 3-kinase inhibitor NVP-BEZ235.

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High-resolution genomic and expression analyses of copy number alterations in HER2-amplified breast cancer

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DNA amplifications in breast cancer: genotypic-phenotypic correlations

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A census of amplified and overexpressed human cancer genes

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Integrative molecular and functional profiling of ERBB2-amplified breast cancers identifies new genetic dependencies

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Loss of phosphatase and tensin homolog or phosphoinositol-3 kinase activation and response to trastuzumab or lapatinib in human epidermal growth factor receptor 2-overexpressing locally advanced breast cancers

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31 March 2020

Identifiers

DOI

10.1038/ONC.2013.41

1 reference

Dimensions Publication ID

3 August 2017

1052013034

0 references

1 reference