(Q34618662)

3 August 2017

title

The ultra-potent and selective TLR8 agonist VTX-294 activates human newborn and adult leukocytes. (English)

1 reference

3 August 2017

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David J Dowling

1

1 reference

3 August 2017

Zhen Tan

2

1 reference

3 August 2017

Zofia M Prokopowicz

3

1 reference

3 August 2017

Christine D Palmer

4

1 reference

3 August 2017

Maura-Ann H Matthews

5

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3 August 2017

Gregory N Dietsch

6

1 reference

3 August 2017

Robert M Hershberg

7

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3 August 2017

Ofer Levy

8

1 reference

3 August 2017

language of work or name

English

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publication date

4 March 2013

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3 August 2017

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3 August 2017

volume

8

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3 August 2017

issue

3

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3 August 2017

page(s)

e58164

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Creative Commons Attribution 4.0 International

3 August 2017

copyright license

start time

4 March 2013

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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7 July 2018

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VTX-1463, a novel TLR8 agonist for the treatment of allergic rhinitis

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Phagosomal signaling by Borrelia burgdorferi in human monocytes involves Toll-like receptor (TLR) 2 and TLR8 cooperativity and TLR8-mediated induction of IFN-beta

7 July 2018

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Use of defined TLR ligands as adjuvants within human vaccines.

7 July 2018

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Ontogeny of Toll-like receptor mediated cytokine responses of human blood mononuclear cells

7 July 2018

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Profound lack of interleukin (IL)-12/IL-23p40 in neonates born early in gestation is associated with an increased risk of sepsis

7 July 2018

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7 July 2018

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7 July 2018

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Neonatal innate TLR-mediated responses are distinct from those of adults.

7 July 2018

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AS04, an aluminum salt- and TLR4 agonist-based adjuvant system, induces a transient localized innate immune response leading to enhanced adaptive immunity

7 July 2018

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Neonatal pneumococcal conjugate vaccine immunization primes T cells for preferential Th2 cytokine expression: a randomized controlled trial in Papua New Guinea

7 July 2018

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Safety and efficacy of neonatal vaccination

7 July 2018

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Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans

7 July 2018

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Genetic association and expression studies indicate a role of toll-like receptor 8 in pulmonary tuberculosis

7 July 2018

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The challenges of vaccine responses in early life: selected examples

7 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3587566

Innate immunity of the newborn: basic mechanisms and clinical correlates

7 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3587566

Cooperation of Toll-like receptor signals in innate immune defence

7 July 2018

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7 July 2018

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Unique efficacy of Toll-like receptor 8 agonists in activating human neonatal antigen-presenting cells

7 July 2018

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Toll-like receptor agonists influence the magnitude and quality of memory T cell responses after prime-boost immunization in nonhuman primates

7 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3587566

Yellow fever vaccine YF-17D activates multiple dendritic cell subsets via TLR2, 7, 8, and 9 to stimulate polyvalent immunity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3587566

Innate cellular immune responses in newborns

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3587566

HIV Gag protein conjugated to a Toll-like receptor 7/8 agonist improves the magnitude and quality of Th1 and CD8+ T cell responses in nonhuman primates

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3587566

Innate immunity of the human newborn: distinct cytokine responses to LPS and other Toll-like receptor agonists

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3587566

Identification and characterization of a functional, alternatively spliced Toll-like receptor 7 (TLR7) and genomic disruption of TLR8 in chickens

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3587566

Selective impairment of TLR-mediated innate immunity in human newborns: neonatal blood plasma reduces monocyte TNF-alpha induction by bacterial lipopeptides, lipopolysaccharide, and imiquimod, but preserves the response to R-848.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3587566

A defect in nucleosome remodeling prevents IL-12(p35) gene transcription in neonatal dendritic cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3587566

Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3587566

A novel pharmacological approach to treating cardiac ischemia. Binary conjugates of A1 and A3 adenosine receptor agonists

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3587566

Levels of growth hormone and growth-hormone-releasing factor in cord blood.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3587566

Deficient TACI expression on B lymphocytes of newborn mice leads to defective Ig secretion in response to BAFF or APRIL.

7 July 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0058164

Overall efficacy of HPV-16/18 AS04-adjuvanted vaccine against grade 3 or greater cervical intraepithelial neoplasia: 4-year end-of-study analysis of the randomised, double-blind PATRICIA trial.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0058164

First results of phase 3 trial of RTS,S/AS01 malaria vaccine in African children

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0058164

TLR8 and NOD signaling synergistically induce the production of IL-1β and IL-23 in monocyte-derived DCs and enhance the expression of the feedback inhibitor SOCS2.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3587566

Postnatal Development of Monocyte Cytokine Responses to Bacterial Lipopolysaccharide

26 October 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0058164

Mycobacterium bovis bacille Calmette Guerin infection of human neutrophils induces CXCL8 secretion by MyD88-dependent TLR2 and TLR4 activation

21 January 2018

1 reference

12 December 2020

Expression of Toll-like receptors by neonatal leukocytes

1 reference

12 December 2020

Challenges in infant immunity: implications for responses to infection and vaccines

1 reference

12 December 2020

Hypoxia promotes interleukin-6 and -8 but reduces interleukin-10 production by placental trophoblast cells from preeclamptic pregnancies

1 reference

12 December 2020

TLR-7 and -8 agonists as vaccine adjuvants

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12 December 2020

Assessing the immunopotency of Toll-like receptor agonists in an in vitro tissue-engineered immunological model

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12 December 2020

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12 December 2020

Vaccine adjuvant activity of 3M-052: an imidazoquinoline designed for local activity without systemic cytokine induction

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12 December 2020

Toll-like receptor (TLR) 2-9 agonists-induced cytokines and chemokines: I. Comparison with T cell receptor-induced responses

1 reference

12 December 2020

TLR-TLR cross talk in human PBMC resulting in synergistic and antagonistic regulation of type-1 and 2 interferons, IL-12 and TNF-alpha

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0058164

Identifiers

DOI

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3 August 2017

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3 August 2017

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