(Q34619324)

3 August 2017

title

Early development of the Toll-like receptor 9 agonist, PF-3512676, for the treatment of patients with advanced cancers (English)

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3 August 2017

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3

Arthur M Krieg

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3 August 2017

Ahmad A Tarhini

1

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3 August 2017

John M Kirkwood

series ordinal

2

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3 August 2017

language of work or name

English

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publication date

1 May 2009

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Expert Opinion on Drug Discovery

3 August 2017

published in

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3 August 2017

volume

4

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3 August 2017

issue

5

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3 August 2017

page(s)

587-603

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Next generation of immunotherapy for melanoma

3 August 2017

cites work

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Oligodeoxynucleotide CpG 7909 delivered as intravenous infusion demonstrates immunologic modulation in patients with previously treated non-Hodgkin lymphoma

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Putting the rap on Akt.

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Randomized phase II trial of a toll-like receptor 9 agonist oligodeoxynucleotide, PF-3512676, in combination with first-line taxane plus platinum chemotherapy for advanced-stage non-small-cell lung cancer

21 January 2018

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In vitro augmentation of natural killer cell activity and production of interferon-alpha/beta and -gamma with deoxyribonucleic acid fraction from Mycobacterium bovis BCG.

21 January 2018

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A synthetic single-stranded DNA, poly(dG,dC), induces interferon-alpha/beta and -gamma, augments natural killer activity, and suppresses tumor growth

21 January 2018

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Oligonucleotide sequences required for natural killer cell activation

21 January 2018

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An antisense oligonucleotide complementary to a sequence in I gamma 2b increases gamma 2b germline transcripts, stimulates B cell DNA synthesis, and inhibits immunoglobulin secretion

21 January 2018

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Modification of antisense phosphodiester oligodeoxynucleotides by a 5' cholesteryl moiety increases cellular association and improves efficacy

21 January 2018

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Administration of a Phosphorothioate Oligonucleotide Antisense to Murine Endogenous Retroviral MCF env Causes Immune Effects in Vivo in a Sequence-Specific Manner

21 January 2018

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CpG motifs in bacterial DNA trigger direct B-cell activation

21 January 2018

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Mechanism and function of a newly identified CpG DNA motif in human primary B cells

21 January 2018

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Delineation of a CpG phosphorothioate oligodeoxynucleotide for activating primate immune responses in vitro and in vivo

21 January 2018

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CpG motifs in bacterial DNA and their immune effects

21 January 2018

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Lipofection of synthetic oligodeoxyribonucleotide having a palindromic sequence of AACGTT to murine splenocytes enhances interferon production and natural killer activity

21 January 2018

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CpG motif identification for veterinary and laboratory species demonstrates that sequence recognition is highly conserved

21 January 2018

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Physicochemical properties of phosphorothioate oligodeoxynucleotides

21 January 2018

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Divergent therapeutic and immunologic effects of oligodeoxynucleotides with distinct CpG motifs.

21 January 2018

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Rational design of new CpG oligonucleotides that combine B cell activation with high IFN-alpha induction in plasmacytoid dendritic cells

21 January 2018

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Therapeutic potential of Toll-like receptor 9 activation

21 January 2018

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Identification of CpG oligonucleotide sequences with high induction of IFN-alpha/beta in plasmacytoid dendritic cells

21 January 2018

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Characterization of three CpG oligodeoxynucleotide classes with distinct immunostimulatory activities.

21 January 2018

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Development of TLR9 agonists for cancer therapy

21 January 2018

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Antitumor applications of stimulating toll-like receptor 9 with CpG oligodeoxynucleotides

21 January 2018

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Pathogen recognition and innate immunity

21 January 2018

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Innate immunity: impact on the adaptive immune response

21 January 2018

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Toll-like receptor control of the adaptive immune responses

21 January 2018

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A Toll-like receptor recognizes bacterial DNA

21 January 2018

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Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition

21 January 2018

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CpG motif-independent activation of TLR9 upon endosomal translocation of "natural" phosphodiester DNA.

21 January 2018

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21 January 2018

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Toll-like receptor 9 binds single-stranded CpG-DNA in a sequence- and pH-dependent manner.

21 January 2018

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Structure-activity relationship analysis of substituted 4-quinolinamines, antagonists of immunostimulatory CpG-oligodeoxynucleotides

21 January 2018

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Properties regulating the nature of the plasmacytoid dendritic cell response to Toll-like receptor 9 activation

21 January 2018

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Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction

21 January 2018

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Receptor cross-linking on human plasmacytoid dendritic cells leads to the regulation of IFN-alpha production.

21 January 2018

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Toll-like receptors stimulate human neutrophil function

21 January 2018

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Human monocytes infected with Yersinia pestis express cell surface TLR9 and differentiate into dendritic cells

21 January 2018

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Microbial DNA induces a host defense reaction of human respiratory epithelial cells

21 January 2018

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Expression of Toll-like receptor 9 and response to bacterial CpG oligodeoxynucleotides in human intestinal epithelium.

21 January 2018

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21 January 2018

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21 January 2018

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Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6

21 January 2018

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Evaluation of the toxicity of ISIS 2302, a phosphorothioate oligonucleotide, in a 4-week study in CD-1 mice

21 January 2018

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Synthetic CpG oligodeoxynucleotides accelerate the development of lupus nephritis during preactive phase in NZB x NZWF1 mice

21 January 2018

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Immunostimulatory DNA sequences influence the course of adjuvant arthritis

21 January 2018

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Synthetic unmethylated cytosine-phosphate-guanosine oligodeoxynucleotides are potent stimulators of antileukemia responses in naive and bone marrow transplant recipients

21 January 2018

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Intratumor CpG-Oligodeoxynucleotide Injection Induces Protective Antitumor T Cell Immunity

21 January 2018

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Doxorubicin and paclitaxel enhance the antitumor efficacy of vaccines directed against HER 2/neu in a murine mammary carcinoma model

21 January 2018

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CD4+CD25+ regulatory T cells suppress tumor immunity but are sensitive to cyclophosphamide which allows immunotherapy of established tumors to be curative

21 January 2018

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Recruitment of latent pools of high-avidity CD8(+) T cells to the antitumor immune response

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460440902824784

CpG oligodeoxynucleotide enhances tumor response to radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902824784

Combination of a CpG-oligodeoxynucleotide and a topoisomerase I inhibitor in the therapy of human tumour xenografts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902824784

Repeated administration of cytosine-phosphorothiolated guanine-containing oligonucleotides together with peptide/protein immunization results in enhanced CTL responses with anti-tumor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902824784

Vaccination with tumor peptide in CpG adjuvant protects via IFN-gamma-dependent CD4 cell immunity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902824784

Immunostimulatory oligodeoxynucleotides containing the CpG motif are effective as immune adjuvants in tumor antigen immunization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902824784

Phase 1 evaluation of intralesionally injected TLR9-agonist PF-3512676 in patients with basal cell carcinoma or metastatic melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902824784

Rapid and strong human CD8+ T cell responses to vaccination with peptide, IFA, and CpG oligodeoxynucleotide 7909.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902824784

Prevention of coagulase-negative staphylococcal central venous catheter-related infection using urokinase rinses: a randomized double-blind controlled trial in patients with hematologic malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902824784

Vaccination with NY-ESO-1 protein and CpG in Montanide induces integrated antibody/Th1 responses and CD8 T cells through cross-priming.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902824784

Toll-like receptors 7, 8, and 9: linking innate immunity to autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902824784

Disease-associated bias in T helper type 1 (Th1)/Th2 CD4(+) T cell responses against MAGE-6 in HLA-DRB10401(+) patients with renal cell carcinoma or melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902824784

Prognosis of Premenopausal Breast Cancer and Childbirth Prior to Diagnosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902824784

Intradermal CpG-B activates both plasmacytoid and myeloid dendritic cells in the sentinel lymph node of melanoma patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902824784

10.1517/17460440902824784

21 January 2018

Identifiers

DOI

1 reference

3 August 2017

1 reference