(Q34626915)

3 August 2017

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title

The role of iron and copper in the aetiology of neurodegenerative disorders: therapeutic implications (English)

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3 August 2017

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1

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3 August 2017

7

Mark A Smith

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3 August 2017

3

Craig S Atwood

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3 August 2017

Catherine A. Rottkamp

series ordinal

6

object named as

Catherine A Rottkamp

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3 August 2017

2

Lawrence M Sayre

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3 August 2017

Rudolph J Castellani

4

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3 August 2017

Adam D Cash

series ordinal

5

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3 August 2017

publication date

1 January 2002

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3 August 2017

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3 August 2017

volume

16

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3 August 2017

issue

5

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3 August 2017

page(s)

339-352

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Consequences of manganese replacement of copper for prion protein function and proteinase resistance

3 August 2017

cites work

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12 December 2020

The octapeptide repeat region of prion protein binds Cu(II) in the redox-inactive state

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12 December 2020

4-Hydroxynonenal-derived advanced lipid peroxidation end products are increased in Alzheimer's disease.

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12 December 2020

Increased expression of neurofilament subunit NF-L produces morphological alterations that resemble the pathology of human motor neuron disease

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12 December 2020

Reexamination of the mechanism of hydroxyl radical adducts formed from the reaction between familial amyotrophic lateral sclerosis-associated Cu,Zn superoxide dismutase mutants and H2O2.

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12 December 2020

Aggregation and Motor Neuron Toxicity of an ALS-Linked SOD1 Mutant Independent from Wild-Type SOD1

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12 December 2020

Elevated "hydroxyl radical" generation in vivo in an animal model of amyotrophic lateral sclerosis.

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12 December 2020

Effects of copper on survival of prion protein knockout neurons and glia.

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12 December 2020

Exacerbation of copper toxicity in primary neuronal cultures depleted of cellular glutathione.

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12 December 2020

Prion protein selectively binds copper(II) ions

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12 December 2020

Oxidative stress induces amyloid-like aggregate formation of NACP/alpha-synuclein in vitro

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12 December 2020

Amyotrophic lateral sclerosis: recent insights from genetics and transgenic mice

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12 December 2020

The free radical-generating function of a familial amyotrophic lateral sclerosis-associated D90A Cu,Zn-superoxide dismutase mutant

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12 December 2020

On the functions of monoamine oxidase, the emotions, and adaptation to stress

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12 December 2020

Copper stimulates endocytosis of the prion protein

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12 December 2020

Treatment of Alzheimer's disease with clioquinol

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12 December 2020

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12 December 2020

Occupational exposure to manganese, copper, lead, iron, mercury and zinc and the risk of Parkinson's disease.

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12 December 2020

Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction.

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12 December 2020

Selective oxidation of methionine residues in prion proteins

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12 December 2020

Decreased zinc affinity of amyotrophic lateral sclerosis-associated superoxide dismutase mutants leads to enhanced catalysis of tyrosine nitration by peroxynitrite

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12 December 2020

Chemical evidence for 6-hydroxydopamine to be an endogenous toxic factor in the pathogenesis of Parkinson's disease

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12 December 2020

The inflammation-induced pathological chaperones ACT and apo-E are necessary catalysts of Alzheimer amyloid formation

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12 December 2020

Sequestration of iron by Lewy bodies in Parkinson's disease

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12 December 2020

Oxidative stress and iron are implicated in fragmenting vacuoles of Saccharomyces cerevisiae lacking Cu,Zn-superoxide dismutase

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12 December 2020

Evidence for a novel heme-binding protein, HasAh, in Alzheimer disease.

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12 December 2020

Abeta deposition is associated with neuropil changes, but not with overt neuronal loss in the human amyloid precursor protein V717F (PDAPP) transgenic mouse.

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12 December 2020

Increased neuronal glucose-6-phosphate dehydrogenase and sulfhydryl levels indicate reductive compensation to oxidative stress in Alzheimer disease.

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12 December 2020

Release of copper ions from the familial amyotrophic lateral sclerosis-associated Cu,Zn-superoxide dismutase mutants

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12 December 2020

Chaperone-facilitated copper binding is a property common to several classes of familial amyotrophic lateral sclerosis-linked superoxide dismutase mutants

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12 December 2020

New Reaction Pathways of Dopamine under Oxidative Stress Conditions: Nonenzymatic Iron-Assisted Conversion to Norepinephrine and the Neurotoxins 6-Hydroxydopamine and 6,7-Dihydroxytetrahydroisoquinoline

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12 December 2020

The Aβ Peptide of Alzheimer's Disease Directly Produces Hydrogen Peroxide through Metal Ion Reduction†

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12 December 2020

Myeloperoxidase and horseradish peroxidase catalyze tyrosine nitration in proteins from nitrite and hydrogen peroxide

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12 December 2020

Widespread peroxynitrite-mediated damage in Alzheimer's disease.

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12 December 2020

Copper, iron and zinc in Alzheimer's disease senile plaques

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12 December 2020

Manganese: a transition metal protects nigrostriatal neurons from oxidative stress in the iron-induced animal model of parkinsonism

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12 December 2020

Oxidative damage is the earliest event in Alzheimer disease

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12 December 2020

How important is oxidative damage? Lessons from Alzheimer's disease

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12 December 2020

The stabilization of ferrous iron by a toxic beta-amyloid fragment and by an aluminum salt

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12 December 2020

Induction of HO-1 and NOS in doppel-expressing mice devoid of PrP: implications for doppel function.

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12 December 2020

Is increased redox-active iron in Alzheimer disease a failure of the copper-binding protein ceruloplasmin?

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12 December 2020

Lactotransferrin immunocytochemistry in Alzheimer and normal human brain.

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12 December 2020

The cellular prion protein binds copper in vivo

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12 December 2020

Neurodegeneration with brain iron accumulation, type 1 is characterized by alpha-, beta-, and gamma-synuclein neuropathology

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12 December 2020

Advanced Maillard reaction end products are associated with Alzheimer disease pathology

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12 December 2020

Biochemistry of neurodegeneration

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12 December 2020

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

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12 December 2020

In vitro and in vivo oxidative stress associated with Alzheimer's amyloid beta-peptide (1-42)

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12 December 2020

Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.

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12 December 2020

Protein oxidative damage in a transgenic mouse model of familial amyotrophic lateral sclerosis

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12 December 2020

Oxidative stress and overexpression of manganese superoxide dismutase in patients with Alzheimer's disease

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12 December 2020

Altered reactivity of superoxide dismutase in familial amyotrophic lateral sclerosis

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12 December 2020

Dramatic aggregation of Alzheimer abeta by Cu(II) is induced by conditions representing physiological acidosis.

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12 December 2020

Cytochemical demonstration of oxidative damage in Alzheimer disease by immunochemical enhancement of the carbonyl reaction with 2,4-dinitrophenylhydrazine

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12 December 2020

A novel neurological phenotype in mice lacking mitochondrial manganese superoxide dismutase

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12 December 2020

Strain-specific prion-protein conformation determined by metal ions

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12 December 2020

In Situ Oxidative Catalysis by Neurofibrillary Tangles and Senile Plaques in Alzheimer’s Disease

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12 December 2020

Copper binding to the prion protein: structural implications of four identical cooperative binding sites

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12 December 2020

Mutant superoxide dismutase-1-linked familial amyotrophic lateral sclerosis: molecular mechanisms of neuronal death and protection

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12 December 2020

RNA oxidation is a prominent feature of vulnerable neurons in Alzheimer's disease.

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12 December 2020

Aberrant copper chemistry as a major mediator of oxidative stress in a human cellular model of amyotrophic lateral sclerosis

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12 December 2020

Copper(II)-induced self-oligomerization of alpha-synuclein.

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12 December 2020

Protein disulfide isomerase in Alzheimer disease.

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12 December 2020

Loss of in vitro metal ion binding specificity in mutant copper-zinc superoxide dismutases associated with familial amyotrophic lateral sclerosis

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12 December 2020

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12 December 2020

Benefit of a combined treatment with trientine and ascorbate in familial amyotrophic lateral sclerosis model mice

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12 December 2020

Promotion of transition metal-induced reactive oxygen species formation by beta-amyloid

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12 December 2020

Increased levels of oxidative stress markers detected in the brains of mice devoid of prion protein

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12 December 2020

Amyloid beta peptides do not form peptide-derived free radicals spontaneously, but can enhance metal-catalyzed oxidation of hydroxylamines to nitroxides

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12 December 2020

Mechanisms of neurotoxicity associated with amyloid beta deposition and the role of free radicals in the pathogenesis of Alzheimer's disease: a critical appraisal

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12 December 2020

APPSw transgenic mice develop age-related A beta deposits and neuropil abnormalities, but no neuronal loss in CA1.

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12 December 2020

Benefit of vitamin E, riluzole, and gabapentin in a transgenic model of familial amyotrophic lateral sclerosis

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12 December 2020

Reactions of hydrogen peroxide with familial amyotrophic lateral sclerosis mutant human copper-zinc superoxide dismutases studied by pulse radiolysis

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12 December 2020

The role of iron in senescence of dopaminergic neurons in Parkinson's disease.

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12 December 2020

The familial amyotrophic lateral sclerosis-associated amino acid substitutions E100G, G93A, and G93R do not influence the rate of inactivation of copper- and zinc-containing superoxide dismutase by H2O2

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12 December 2020

Raman spectroscopic study on the copper(II) binding mode of prion octapeptide and its pH dependence

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12 December 2020

Subunit asymmetry in the three-dimensional structure of a human CuZnSOD mutant found in familial amyotrophic lateral sclerosis

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12 December 2020

Increased cerebral glucose-6-phosphate dehydrogenase activity in Alzheimer's disease may reflect oxidative stress

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12 December 2020

Normal prion protein has an activity like that of superoxide dismutase.

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12 December 2020

Prion protein glycosylation is sensitive to redox change

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12 December 2020

Prion protein-deficient neurons reveal lower glutathione reductase activity and increased susceptibility to hydrogen peroxide toxicity

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12 December 2020

Abnormal localization of iron regulatory protein in Alzheimer's disease

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12 December 2020

Methionine residue 35 is important in amyloid beta-peptide-associated free radical oxidative stress.

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12 December 2020

Astrocytes, brain aging, and neurodegeneration

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12 December 2020

Transition Metals, Ferritin, Glutathione, and Ascorbic Acid in Parkinsonian Brains

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12 December 2020

Increased regional brain concentrations of ceruloplasmin in neurodegenerative disorders

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12 December 2020

Redox-active iron mediates amyloid-beta toxicity

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12 December 2020

Iron, melanin and dopamine interaction: relevance to Parkinson's disease

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12 December 2020

Lipoperoxidation is selectively involved in progressive supranuclear palsy

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12 December 2020

Neuron loss in APP transgenic mice

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12 December 2020

Evidence of oxidative stress and in vivo neurotoxicity of beta-amyloid in a transgenic mouse model of Alzheimer's disease: a chronic oxidative paradigm for testing antioxidant therapies in vivo

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12 December 2020

Overexpression of human copper, zinc-superoxide dismutase (SOD1) prevents postischemic injury

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12 December 2020

Differential effects of apolipoprotein E isoforms on metal-induced aggregation of A beta using physiological concentrations.

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12 December 2020

Copper-binding amyloid precursor protein undergoes a site-specific fragmentation in the reduction of hydrogen peroxide

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12 December 2020

Role of cytochrome c as a stimulator of alpha-synuclein aggregation in Lewy body disease

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12 December 2020

Iron in the basal ganglia in Parkinson's disease. An in vitro study using extended X-ray absorption fine structure and cryo-electron microscopy

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12 December 2020

Aluminum, iron, and zinc ions promote aggregation of physiological concentrations of beta-amyloid peptide.

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12 December 2020

Increased oxidative damage is correlated to altered mitochondrial function in heterozygous manganese superoxide dismutase knockout mice

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12 December 2020

High molecular weight neurofilament proteins are physiological substrates of adduction by the lipid peroxidation product hydroxynonenal

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12 December 2020

Expression of iron transport proteins and excessive iron accumulation in the brain in neurodegenerative disorders

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12 December 2020

Amyloid-beta deposition in Alzheimer transgenic mice is associated with oxidative stress

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12 December 2020

Copper chaperone for superoxide dismutase is essential to activate mammalian Cu/Zn superoxide dismutase

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12 December 2020

Intramuscular desferrioxamine in patients with Alzheimer's disease

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12 December 2020

In Alzheimer's disease, heme oxygenase is coincident with Alz50, an epitope of tau induced by 4-hydroxy-2-nonenal modification.

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12 December 2020

Imbalances of trace elements related to oxidative damage in Alzheimer's disease brain.

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12 December 2020

Prion protein expression and superoxide dismutase activity

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12 December 2020

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12 December 2020

Neuronal oxidative stress precedes amyloid-beta deposition in Down syndrome

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12 December 2020

The copper chaperone for superoxide dismutase

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12 December 2020

Quinone reductase (NQO1), a sensitive redox indicator, is increased in Alzheimer's disease

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12 December 2020

Iron accumulation in Alzheimer disease is a source of redox-generated free radicals

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12 December 2020

The copper chelator d-penicillamine delays onset of disease and extends survival in a transgenic mouse model of familial amyotrophic lateral sclerosis

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12 December 2020

Aqueous dissolution of Alzheimer's disease Abeta amyloid deposits by biometal depletion

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12 December 2020

Reactive Oxygen Species Mediate Cellular Damage in Alzheimer Disease.

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12 December 2020

Pharmacological treatment of cognitive deficits in Alzheimer's disease.

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12 December 2020

Ferritin is associated with the aberrant tau filaments present in progressive supranuclear palsy

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12 December 2020

Astrocyte mitochondria: a substrate for iron deposition in the aging rat substantia nigra

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12 December 2020

Hindlimb motor neurons require Cu/Zn superoxide dismutase for maintenance of neuromuscular junctions

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12 December 2020

Copper levels are increased in the cerebral cortex and liver of APP and APLP2 knockout mice

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12 December 2020

The cellular prion protein binds copper in vivo

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12 December 2020

10.2165/00023210-200216050-00006

Identifiers

DOI

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Dimensions Publication ID

3 August 2017

1036679786

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