(Q34631552)

3 August 2017

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title

A continuum model for tumour suppression (English)

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3 August 2017

3

Pier Paolo Pandolfi

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author name string

Alice H Berger

series ordinal

1

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3 August 2017

Alfred G Knudson

series ordinal

2

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3 August 2017

language of work or name

English

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publication date

10 August 2011

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3 August 2017

7

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inferred from page(s)

published in

Nature

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3 August 2017

476

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3 August 2017

163-169

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3 August 2017

7359

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https://scigraph.springernature.com/pub.10.1038/nature10275

3 August 2017

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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A coding-independent function of gene and pseudogene mRNAs regulates tumour biology

7 July 2018

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Subtle variations in Pten dose determine cancer susceptibility

7 July 2018

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Identification of the miR-106b~25 microRNA cluster as a proto-oncogenic PTEN-targeting intron that cooperates with its host gene MCM7 in transformation

7 July 2018

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Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence

7 July 2018

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A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis

7 July 2018

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7 July 2018

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7 July 2018

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Monoallelic but not biallelic loss of Dicer1 promotes tumorigenesis in vivo

7 July 2018

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Dicer1 functions as a haploinsufficient tumor suppressor

7 July 2018

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Functional identification of tumor-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma model

7 July 2018

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The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo

7 July 2018

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Altered proliferation and differentiation properties of primary mammary epithelial cells from BRCA1 mutation carriers.

7 July 2018

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MicroRNAs: target recognition and regulatory functions

7 July 2018

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Somatic mutations affect key pathways in lung adenocarcinoma

7 July 2018

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Genome wide identification of recessive cancer genes by combinatorial mutation analysis

7 July 2018

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7 July 2018

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7 July 2018

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Regulation of the PTEN promoter by statins and SREBP.

7 July 2018

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Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia

7 July 2018

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Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells

7 July 2018

1 reference

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Loss of one p53 allele results in four-fold reduction of p53 mRNA and protein: a basis for p53 haplo-insufficiency

7 July 2018

1 reference

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Tumor suppressor genetics

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3206311

Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

7 July 2018

1 reference

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Role of nucleophosmin in embryonic development and tumorigenesis

7 July 2018

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Mechanisms of haploinsufficiency revealed by genome-wide profiling in yeast

7 July 2018

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Cancer genes and the pathways they control

7 July 2018

1 reference

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Pten dose dictates cancer progression in the prostate

7 July 2018

1 reference

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Chromosome studies on normal and leukemic human leukocytes

7 July 2018

1 reference

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Cancer biology. A matter of dosage

7 July 2018

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Mitotic recombination map of 13cen-13q14 derived from an investigation of loss of heterozygosity in retinoblastomas

7 July 2018

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Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems

7 July 2018

1 reference

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Retention of wild-type p53 in tumors from p53 heterozygous mice: reduction of p53 dosage can promote cancer formation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3206311

Pten is essential for embryonic development and tumour suppression

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3206311

Li-Fraumeni syndrome--a molecular and clinical review

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3206311

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3206311

The multistep nature of cancer

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3206311

Inactivation of both APC alleles in human and mouse tumors

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3206311

Expression of recessive alleles by chromosomal mechanisms in retinoblastoma

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3206311

Localization of the c-abl oncogene adjacent to a translocation break point in chronic myelocytic leukaemia

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3206311

Mutation and cancer: statistical study of retinoblastoma

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3206311

Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3206311

Genetic origin of mutations predisposing to retinoblastoma

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3206311

Human retinoblastoma susceptibility gene: cloning, identification, and sequence.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3206311

The analysis of malignancy by cell fusion: the position in 1988.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3206311

Structural evidence for the authenticity of the human retinoblastoma gene

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3206311

A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3206311

Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3206311

Induction of apoptosis in fibroblasts by c-myc protein

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3206311

Uninfected vertebrate cells contain a protein that is closely related to the product of the avian sarcoma virus transforming gene (src)

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3206311

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3206311

F-box and WD repeat domain-containing 7 regulates intestinal cell lineage commitment and is a haploinsufficient tumor suppressor.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3206311

Epidermal growth factor receptor gene mutations and increased copy numbers predict gefitinib sensitivity in patients with recurrent non-small-cell lung cancer

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3206311

Thymocyte apoptosis induced by p53-dependent and independent pathways.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3206311

Different tumor types from BRCA2 carriers show wild-type chromosome deletions on 13q12-q13

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3206311

Patient with 13 Chromosome Deletion: Evidence That the Retinoblastoma Gene Is a Recessive Cancer Gene

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3206311

Human haploinsufficiency — one for sorrow, two for joy

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3206311

Allele losses in the region 17q12-21 in familial breast and ovarian cancer involve the wild-type chromosome

9 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3206311

15/17 translocation, a consistent chromosomal change in acute promyelocytic leukaemia

9 December 2018

1 reference

12 December 2020

Gene for hereditary retinoblastoma assigned to human chromosome 13 by linkage to esterase D

1 reference

12 December 2020

Homozygosity of chromosome 13 in retinoblastoma

1 reference

12 December 2020

Structure and origin of the acute promyelocytic leukemia myl/RAR alpha cDNA and characterization of its retinoid-binding and transactivation properties

1 reference

12 December 2020

High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice

1 reference

12 December 2020

Impaired Fas response and autoimmunity in Pten+/- mice

1 reference

12 December 2020

Conditional loss of uterine Pten unfailingly and rapidly induces endometrial cancer in mice

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNATURE10275

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/NATURE10275

1 reference

Dimensions Publication ID

3 August 2017

0 references

1 reference

3 August 2017

1 reference