(Q34643623)

3 August 2017

title

Piecing together the family portrait of TCR-CD3 complexes (English)

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3 August 2017

Michael S Kuhns

1

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3 August 2017

Hemant B Badgandi

series ordinal

2

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3 August 2017

language of work or name

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1 November 2012

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3 August 2017

published in

Immunological Reviews

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3 August 2017

volume

250

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3 August 2017

issue

1

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3 August 2017

page(s)

120-143

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T-cell antigen receptor genes and T-cell recognition

3 August 2017

cites work

1 reference

Disorderly conduct in gammadelta versus alphabeta T cell lineage commitment.

21 January 2018

1 reference

gammadeltaTCR ligands and lineage commitment

21 January 2018

1 reference

gammadelta and alphabeta T cell lineage choice: resolution by a stronger sense of being

21 January 2018

1 reference

Ligand recognition during thymic development and gammadelta T cell function specification

21 January 2018

1 reference

Beyond alphabeta/gammadelta lineage commitment: TCR signal strength regulates gammadelta T cell maturation and effector fate

21 January 2018

1 reference

Towards a molecular understanding of the differential signals regulating alphabeta/gammadelta T lineage choice

21 January 2018

1 reference

Unique features of the pre-T-cell receptor alpha-chain: not just a surrogate

21 January 2018

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Positive and negative selection of T cells

21 January 2018

1 reference

Strength of TCR-peptide/MHC interactions and in vivo T cell responses

21 January 2018

1 reference

Vaccine adjuvants alter TCR-based selection thresholds.

21 January 2018

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Complete but curtailed T-cell response to very low-affinity antigen

21 January 2018

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Attenuated T cell responses to a high-potency ligand in vivo

21 January 2018

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Induction of Th1 and Th2 CD4+ T cell responses: the alternative approaches

21 January 2018

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The function of follicular helper T cells is regulated by the strength of T cell antigen receptor binding

21 January 2018

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TCR ligand density and affinity determine peripheral induction of Foxp3 in vivo

21 January 2018

1 reference

Effector and memory CTL differentiation

21 January 2018

1 reference

Origins of CD4(+) effector and central memory T cells

21 January 2018

1 reference

CD3-specific antibodies restore self-tolerance: mechanisms and clinical applications

21 January 2018

1 reference

CD3-specific antibodies: a portal to the treatment of autoimmunity

21 January 2018

1 reference

T cells as a self-referential, sensory organ

21 January 2018

1 reference

21 January 2018

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TCR Signaling Emerges from the Sum of Many Parts

21 January 2018

1 reference

The molecular basis of TCR germline bias for MHC is surprisingly simple

21 January 2018

1 reference

Unique Interplay between Sugar and Lipid in Determining the Antigenic Potency of Bacterial Antigens for NKT Cells

21 January 2018

1 reference

Structure of a gammadelta T cell receptor in complex with the nonclassical MHC T22.

21 January 2018

1 reference

Thymic selection determines gammadelta T cell effector fate: antigen-naive cells make interleukin-17 and antigen-experienced cells make interferon gamma

21 January 2018

1 reference

Common themes in the assembly and architecture of activating immune receptors

21 January 2018

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The T cell receptor/CD3 complex is composed of at least two autonomous transduction modules.

21 January 2018

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An alphabeta T cell receptor structure at 2.5 A and its orientation in the TCR-MHC complex

21 January 2018

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How the T cell receptor sees antigen--a structural view

21 January 2018

1 reference

Deconstructing the form and function of the TCR/CD3 complex

21 January 2018

1 reference

Evidence for a functional sidedness to the alphabetaTCR.

21 January 2018

1 reference

Structure of a human gammadelta T-cell antigen receptor

21 January 2018

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The structural basis for autonomous dimerization of the pre-T-cell antigen receptor

21 January 2018

1 reference

Evolution of protein fold in the presence of functional constraints

21 January 2018

1 reference

Transitive homology-guided structural studies lead to discovery of Cro proteins with 40% sequence identity but different folds

21 January 2018

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Convergent solutions to binding at a protein-protein interface

21 January 2018

1 reference

The alphabeta T cell receptor is an anisotropic mechanosensor.

21 January 2018

1 reference

Restoring the association of the T cell receptor with CD8 reverses anergy in human tumor-infiltrating lymphocytes

21 January 2018

1 reference

Turning 'sweet' on immunity: galectin-glycan interactions in immune tolerance and inflammation

21 January 2018

1 reference

One of the CD3epsilon subunits within a T cell receptor complex lies in close proximity to the Cbeta FG loop

21 January 2018

1 reference

Solution structure of the CD3epsilondelta ectodomain and comparison with CD3epsilongamma as a basis for modeling T cell receptor topology and signaling

21 January 2018

1 reference

A structural basis for the selection of dominant alphabeta T cell receptors in antiviral immunity

21 January 2018

1 reference

Antigen ligation triggers a conformational change within the constant domain of the alphabeta T cell receptor

21 January 2018

1 reference

T Cell Receptors are Structures Capable of Initiating Signaling in the Absence of Large Conformational Rearrangements

21 January 2018

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Atomic structure of an alphabeta T cell receptor (TCR) heterodimer in complex with an anti-TCR fab fragment derived from a mitogenic antibody

21 January 2018

1 reference

Involvement of the TCR Cbeta FG loop in thymic selection and T cell function

21 January 2018

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Impaired NK1.1 T cell development in mice transgenic for a T cell receptor beta chain lacking the large, solvent-exposed cbeta FG loop

21 January 2018

1 reference

A membrane-proximal tetracysteine motif contributes to assembly of CD3deltaepsilon and CD3gammaepsilon dimers with the T cell receptor.

21 January 2018

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A motif within the T cell receptor alpha chain constant region connecting peptide domain controls antigen responsiveness.

21 January 2018

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Signaling efficiency of the T cell receptor controlled by a single amino acid in the beta chain constant region

21 January 2018

1 reference

CART: a conserved antigen receptor transmembrane motif

21 January 2018

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Transmembrane helical interactions and the assembly of the T cell receptor complex

21 January 2018

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Regions of the T cell receptor alpha and beta chains that are responsible for interactions with CD3.

21 January 2018

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The organizing principle in the formation of the T cell receptor-CD3 complex.

21 January 2018

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Serine residues in the cytosolic tail of the T-cell antigen receptor alpha-chain mediate ubiquitination and endoplasmic reticulum-associated degradation of the unassembled protein

21 January 2018

1 reference

A Conserved Hydrophobic Patch on Vβ Domains Revealed by TCRβ Chain Crystal Structures: Implications for Pre-TCR Dimerization

21 January 2018

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Thymocyte development in the absence of pre-T cell receptor extracellular immunoglobulin domains

21 January 2018

1 reference

Identification of the pre-T-cell receptor alpha chain in nonmammalian vertebrates challenges the structure-function of the molecule

21 January 2018

1 reference

The biological activity of natural and mutant pTalpha alleles

21 January 2018

1 reference

PreTCR and TCRγδ signal initiation in thymocyte progenitors does not require domains implicated in receptor oligomerization

21 January 2018

1 reference

Germ-line elimination of electric charge on pre-T-cell receptor (TCR) impairs autonomous signaling for beta-selection and TCR repertoire formation

21 January 2018

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alpha beta T cell development is abolished in mice lacking both Lck and Fyn protein tyrosine kinases

21 January 2018

1 reference

On the role of the pre-T cell receptor in alphabeta versus gammadelta T lineage commitment

21 January 2018

1 reference

Restoration of thymopoiesis in pT alpha-/- mice by anti-CD3epsilon antibody treatment or with transgenes encoding activated Lck or tailless pT alpha.

21 January 2018

1 reference

CDR3 length in antigen-specific immune receptors

21 January 2018

1 reference

Positive selection through a motif in the alphabeta T cell receptor

21 January 2018

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CD3 delta deficiency arrests development of the alpha beta but not the gamma delta T cell lineage

21 January 2018

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Subunit composition of pre-T cell receptor complexes expressed by primary thymocytes: CD3 delta is physically associated but not functionally required.

21 January 2018

1 reference

Different composition of the human and the mouse gammadelta T cell receptor explains different phenotypes of CD3gamma and CD3delta immunodeficiencies

21 January 2018

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Crystal structure of the human T cell receptor CD3 epsilon gamma heterodimer complexed to the therapeutic mAb OKT3.

21 January 2018

1 reference

Crystal structure of a human CD3-epsilon/delta dimer in complex with a UCHT1 single-chain antibody fragment.

21 January 2018

1 reference

The T cell antigen receptor alpha and beta chains interact via distinct regions with CD3 chains

21 January 2018

1 reference

The implications of subunit interactions for the structure of the T cell receptor-CD3 complex

21 January 2018

1 reference

The short length of the extracellular domain of zeta is crucial for T cell antigen receptor function

21 January 2018

1 reference

A conserved CXXC motif in CD3epsilon is critical for T cell development and TCR signaling

21 January 2018

1 reference

The structure of the zetazeta transmembrane dimer reveals features essential for its assembly with the T cell receptor

21 January 2018

1 reference

The T cell receptor: critical role of the membrane environment in receptor assembly and function

21 January 2018

1 reference

The structural basis for intramembrane assembly of an activating immunoreceptor complex

21 January 2018

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Antigen receptor tail clue.

21 January 2018

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Organization of proximal signal initiation at the TCR:CD3 complex

21 January 2018

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Intramolecular regulatory switch in ZAP-70: analogy with receptor tyrosine kinases.

21 January 2018

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Regulation of T Cell Receptor Activation by Dynamic Membrane Binding of the CD3ɛ Cytoplasmic Tyrosine-Based Motif

21 January 2018

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Basic residues in the T-cell receptor ζ cytoplasmic domain mediate membrane association and modulate signaling

21 January 2018

1 reference

Lipid-binding activity of intrinsically unstructured cytoplasmic domains of multichain immune recognition receptor signaling subunits

21 January 2018

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The CD3 zeta subunit contains a phosphoinositide-binding motif that is required for the stable accumulation of TCR-CD3 complex at the immunological synapse

21 January 2018

1 reference

The cytoplasmic tail of the T cell receptor CD3 epsilon subunit contains a phospholipid-binding motif that regulates T cell functions

21 January 2018

1 reference

The safety on the TCR trigger

21 January 2018

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The serine and threonine residues in the Ig-alpha cytoplasmic tail negatively regulate immunoreceptor tyrosine-based activation motif-mediated signal transduction

21 January 2018

1 reference

Mapping T-cell receptor–peptide contacts by variant peptide immunization of single-chain transgenics

21 January 2018

1 reference

Structural Basis of Specificity and Cross-Reactivity in T Cell Receptors Specific for Cytochrome c-I-E

21 January 2018

1 reference

New insights into the T cell synapse from single molecule techniques

21 January 2018

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Molecular dynamics in the membranes of helper T cells

21 January 2018

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Deletion of CD4 and CD8 coreceptors permits generation of alphabetaT cells that recognize antigens independently of the MHC.

21 January 2018

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The T cell receptor's alpha-chain connecting peptide motif promotes close approximation of the CD8 coreceptor allowing efficient signal initiation

21 January 2018

1 reference

Crystal structure of the human CD4 N-terminal two-domain fragment complexed to a class II MHC molecule

21 January 2018

1 reference

How TCRs bind MHCs, peptides, and coreceptors

21 January 2018

1 reference

T Cell Receptor Signaling Is Limited by Docking Geometry to Peptide-Major Histocompatibility Complex

21 January 2018

1 reference

Crystal structure of a complete ternary complex of T-cell receptor, peptide-MHC, and CD4

21 January 2018

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Inhibition of T cell receptor-coreceptor interactions by antagonist ligands visualized by live FRET imaging of the T-hybridoma immunological synapse

21 January 2018

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Direct observation of ligand recognition by T cells.

21 January 2018

1 reference

Agonist/endogenous peptide-MHC heterodimers drive T cell activation and sensitivity

21 January 2018

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Surface-anchored monomeric agonist pMHCs alone trigger TCR with high sensitivity

21 January 2018

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The two membrane proximal domains of CD4 interact with the T cell receptor

21 January 2018

1 reference

T Cell Receptor Binding to a pMHCII Ligand Is Kinetically Distinct from and Independent of CD4.

21 January 2018

1 reference

The nature of molecular recognition by T cells

21 January 2018

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The function of the CD4 coreceptor in the development of T cells

21 January 2018

1 reference

The IFN gamma receptor: a paradigm for cytokine receptor signaling

21 January 2018

1 reference

Structural biology of shared cytokine receptors

21 January 2018

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Convergent evolution of similar function in two structurally divergent enzymes

21 January 2018

1 reference

Crystal structure of a monomeric retroviral protease solved by protein folding game players

21 January 2018

1 reference

MHC class II interaction with CD4 mediated by a region analogous to the MHC class I binding site for CD8

21 January 2018

1 reference

Mechanistic basis of pre–T cell receptor–mediated autonomous signaling critical for thymocyte development

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1111/IMR.12000

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3 August 2017

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