(Q34648882)

3 August 2017

1 reference

title

The Apaf-1 apoptosome: a large caspase-activating complex (English)

1 reference

3 August 2017

1 reference

Kelvin Cain

1

1 reference

PubMed ID

12022951

3 August 2017

Shawn B Bratton

series ordinal

2

1 reference

PubMed ID

12022951

3 August 2017

Gerald M Cohen

series ordinal

3

1 reference

3 August 2017

1 February 2002

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3 August 2017

1 reference

3 August 2017

84

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3 August 2017

203-214

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3 August 2017

2-3

1 reference

Caspases: the executioners of apoptosis

3 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

Caspases: enemies within

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

Caspase structure, proteolytic substrates, and function during apoptotic cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

The biochemistry of apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

Mammalian caspases: structure, activation, substrates, and functions during apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

Genetic control of programmed cell death in the nematode C. elegans.

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

The C. elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

Protein complexes activate distinct caspase cascades in death receptor and stress-induced apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

The CD95 (APO-1/Fas) and the TRAIL (APO-2L) apoptosis systems

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

Biochemistry and function of the DISC

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

Mechanisms of CD95 (APO-1/Fas)-mediated apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

Apoptosis CED-4 is a stranger no more

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

Caspase activation involves the formation of the aposome, a large (approximately 700 kDa) caspase-activating complex

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

Cytochrome c and dATP-mediated oligomerization of Apaf-1 is a prerequisite for procaspase-9 activation

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

Recruitment, activation and retention of caspases-9 and -3 by Apaf-1 apoptosome and associated XIAP complexes

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

Cleavage of lamin A by Mch2 alpha but not CPP32: multiple interleukin 1 beta-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

Catalytic properties of the caspases

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

Pro-caspase-3 is a major physiologic target of caspase-8.

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

The Ced-3/interleukin 1beta converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2alpha are substrates for the apoptotic mediator CPP32

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

Caspase-9 can be activated without proteolytic processing

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

Structure and mechanism of interleukin-1 beta converting enzyme

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

The three-dimensional structure of apopain/CPP32, a key mediator of apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

Genetics of programmed cell death in C. elegans: past, present and future.

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

Translocation of C. elegans CED-4 to nuclear membranes during programmed cell death.

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

Essential role of CED-4 oligomerization in CED-3 activation and apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

An induced proximity model for caspase-8 activation.

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

Autoproteolytic activation of pro-caspases by oligomerization.

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

Apoptosis. Death by crowd control

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

Control of the cell death pathway by Dapaf-1, a Drosophila Apaf-1/CED-4-related caspase activator

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

Dark is a Drosophila homologue of Apaf-1/CED-4 and functions in an evolutionarily conserved death pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

HAC-1, a Drosophila homolog of APAF-1 and CED-4 functions in developmental and radiation-induced apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

An essential role for the caspase dronc in developmentally programmed cell death in Drosophila.

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

Altered cytochrome c display precedes apoptotic cell death in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

Apaf1 is required for mitochondrial pathways of apoptosis and brain development

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

Differential requirement for caspase 9 in apoptotic pathways in vivo.

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

Cytochrome c deficiency causes embryonic lethality and attenuates stress-induced apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

Oncogene-dependent apoptosis is mediated by caspase-9.

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

Role of cytochrome c and dATP/ATP hydrolysis in Apaf-1-mediated caspase-9 activation and apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

Expression and functional analysis of Apaf-1 isoforms. Extra Wd-40 repeat is required for cytochrome c binding and regulated activation of procaspase-9

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

The WD repeat: a common architecture for diverse functions

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

Haem-ligand switching during catalysis in crystals of a nitrogen-cycle enzyme

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

The CARD domain: a new apoptotic signalling motif

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

WD-40 repeat region regulates Apaf-1 self-association and procaspase-9 activation

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

Cytochrome c promotes caspase-9 activation by inducing nucleotide binding to Apaf-1

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

Apoptosis and necrosis: different execution of the same death

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

Regulation of apoptotic protease activating factor-1 oligomerization and apoptosis by the WD-40 repeat region

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

Apaf-1 oligomerizes into biologically active approximately 700-kDa and inactive approximately 1.4-MDa apoptosome complexes

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

Caspase-3 cleaves Apaf-1 into an approximately 30 kDa fragment that associates with an inappropriately oligomerized and biologically inactive approximately 1.4 MDa apoptosome complex

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

Cytochrome c binding to Apaf-1: the effects of dATP and ionic strength

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

Elevated extracellular [K+] inhibits death-receptor- and chemical-mediated apoptosis prior to caspase activation and cytochrome c release

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

Physiological concentrations of K+ inhibit cytochrome c-dependent formation of the apoptosome

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

A mutational epitope for cytochrome C binding to the apoptosis protease activation factor-1

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

Caspase-9 and APAF-1 form an active holoenzyme

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

Structural basis of procaspase-9 recruitment by the apoptotic protease-activating factor 1

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

Solution structure of Apaf-1 CARD and its interaction with caspase-9 CARD: a structural basis for specific adaptor/caspase interaction

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

The adapter protein apoptotic protease-activating factor-1 (Apaf-1) is proteolytically processed during apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

Transforming growth factor-beta(1) induces apoptosis in rat FaO hepatoma cells via cytochrome c release and oligomerization of Apaf-1 to form a approximately 700-kd apoptosome caspase-processing complex

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

X-linked IAP is a direct inhibitor of cell-death proteases

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

IAP family proteins--suppressors of apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

XIAP, the guardian angel

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

NMR structure and mutagenesis of the inhibitor-of-apoptosis protein XIAP

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

NMR structure and mutagenesis of the third Bir domain of the inhibitor of apoptosis protein XIAP

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

DIABLO promotes apoptosis by removing MIHA/XIAP from processed caspase 9

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

Structural and biochemical basis of apoptotic activation by Smac/DIABLO

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

Molecular determinants of the caspase-promoting activity of Smac/DIABLO and its role in the death receptor pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

Structural basis of IAP recognition by Smac/DIABLO

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

The inhibitor of apoptosis protein-binding domain of Smac is not essential for its proapoptotic activity

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

Identification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts inhibitor of apoptosis protein-caspase interaction

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

Bcl-XL interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

Bcl-2 family members do not inhibit apoptosis by binding the caspase activator Apaf-1

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

Pro-apoptotic apoptosis protease-activating factor 1 (Apaf-1) has a cytoplasmic localization distinct from Bcl-2 or Bcl-x(L).

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

Stress management - heat shock protein-70 and the regulation of apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

Negative regulation of the Apaf-1 apoptosome by Hsp70

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

Negative regulation of cytochrome c-mediated oligomerization of Apaf-1 and activation of procaspase-9 by heat shock protein 90

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

Hsp27 negatively regulates cell death by interacting with cytochrome c.

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

Apoptosis in human monocytic THP.1 cells involves several distinct targets of N-tosyl-L-phenylalanyl chloromethyl ketone (TPCK)

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

Proteasome inhibitor-induced apoptosis of B-chronic lymphocytic leukaemia cells involves cytochrome c release and caspase activation, accompanied by formation of an approximately 700 kDa Apaf-1 containing apoptosome complex

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2901376-7

7 January 2021

10.1016/S0300-9084(02)01376-7

Identifiers

DOI

1 reference

3 August 2017

1 reference

PubMed ID

12022951